Drug Information

  


















Pharmacokinetics





Following intravenous
administration vecuronium is rapidly distributed. It is taken up by the
liver and partly metabolised; the metabolites have some neuromuscular
blocking activity. It is excreted mainly in bile as unchanged drug and
metabolites; some is also excreted in urine. The plasma elimination
half-life is reported to range from about 30 to 80 minutes.

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Indication
& Dosage


 

Adjunct to
general anaeshtesia to facilitate endeotracheal intubation & to
provede skeletal muscle relaxation




Dosage:
Has to be individualised Intubation: 0.8mg/kg. Surgical
procedures after intubation with succinylcholine:  0.03 to 0.05mg/
kg body wt. Use of vecuronium should be delayed till the patient has
clinically recovered from the neuromuscular block induced by
succinylcholine

Maintenance dose: 0.02 to 0.03 mg per kg.

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Action



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Interactions

 



Incompatibility with alkaline solutio(barbiturates such as thipentone
sodium). 

Inhalational anaesthetics: halothane, isoflurance amy enhance effect.

Antiarrhythmic: Lignocaine, quinidine and verapamil may enhanced effect.

Antibacterial: Aminoglycoside, lincosamide, polymixins & rarely
tetracyclines may enhace effect.

Anticholinestrases: Neostigmine may enhance effect.

Antiepileptics: Carbamazepine and phenytoin may reduce effect.

Ganglion blockers: May enhance effect.

Xanthines: Aminophylline and theophlline may antagonise the effect.

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Adverse
Effect & Precaution


 

Transient fall in blood pressure, slight increase in heart rate,
reduction in GI motility, rarely bronchospasm and anaphylactoid
reaction.



Precaution: Hepatic and renal impairment. Dose adjustment may be
required in infants. Severe obesity. Malignant hyperthermia.

Pregnancy: Safety not established.

Breast Feeding: Use only if clearly indicated.

Man: Use with caution.

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Brand
available in market








 

 

 

 

NORCURON

 

 

Infar

INJ

4mg

1ml

112.50

VECURON

 

 

Globus

INJ

4mg

2ml

57.00

 

 

 

 

 



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Drug Information
  

Pharmacokinetics

Following intravenous administration vecuronium is rapidly distributed. It is taken up by the liver and partly metabolised; the metabolites have some neuromuscular blocking activity. It is excreted mainly in bile as unchanged drug and metabolites; some is also excreted in urine. The plasma elimination half-life is reported to range from about 30 to 80 minutes.

TOP
   

Indication & Dosage
 
Adjunct to general anaeshtesia to facilitate endeotracheal intubation & to provede skeletal muscle relaxation

Dosage: Has to be individualised Intubation: 0.8mg/kg. Surgical procedures after intubation with succinylcholine:  0.03 to 0.05mg/ kg body wt. Use of vecuronium should be delayed till the patient has clinically recovered from the neuromuscular block induced by succinylcholine
Maintenance dose: 0.02 to 0.03 mg per kg.

TOP
   

Action


TOP
   

Interactions
 
Incompatibility with alkaline solutio(barbiturates such as thipentone sodium). 
Inhalational anaesthetics: halothane, isoflurance amy enhance effect.
Antiarrhythmic: Lignocaine, quinidine and verapamil may enhanced effect.
Antibacterial: Aminoglycoside, lincosamide, polymixins & rarely tetracyclines may enhace effect.
Anticholinestrases: Neostigmine may enhance effect.
Antiepileptics: Carbamazepine and phenytoin may reduce effect.
Ganglion blockers: May enhance effect.
Xanthines: Aminophylline and theophlline may antagonise the effect.

TOP
   

Adverse Effect & Precaution
 
Transient fall in blood pressure, slight increase in heart rate, reduction in GI motility, rarely bronchospasm and anaphylactoid reaction.

Precaution: Hepatic and renal impairment. Dose adjustment may be required in infants. Severe obesity. Malignant hyperthermia.
Pregnancy: Safety not established.
Breast Feeding: Use only if clearly indicated.
Man: Use with caution.

TOP
   

Brand available in market

 

 

 

 

NORCURON

 

 

Infar

INJ

4mg

1ml

112.50

VECURON

 

 

Globus

INJ

4mg

2ml

57.00

 

 

 

 

 

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By |2022-07-20T16:44:34+00:00July 20, 2022|Uncategorized|Comments Off on Vecuronium

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