Drug Information

  













Pharmacokinetics


Given orally, it has a high hepatic metabolism. Hence a
higher dose by oral route should be used than by the I.V route. It is
highly protein bound.

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Indication
& Dosage


 

Oral

PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA, ATRIAL FLUTTER AND FIBRILLATION
EXTRA SYSTOLES:
40-80mg t.i.d Max daily dose 480mg.

IV

ACUTE CORONARY INSUFFICIENCY (CORONARY SPASM)
:
IV injections under ECG
control: 5-10mg over 2-3 mins. A further 5mg if necessary may be
injected 5-10 mins after the firs injection. Children: IV doses.
Neonates: 0.75-1mg. Infants: 0.75-2mg 1-5yrs: 2-3mg. 6-15yrs: 2.5-5mg

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Action

 

Verapamil inhibits entry of
calcium ions into arterial smooth muscle cells as well as the myocytes
and conducting tissue. These actions lead to reversal and preventions of
coronary artery spasm,  reduction in afterload through peripheral
vasodilatation and reduction in ventricular rate in patients with
chronic atria flutter or fibrillation and reduction in the ccourence of
paroxysmal supraventrucular tachycardia. Verapamil reduces blood
pressure, relieves angina and controls arrhythmias.

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Interactions


 

Interaction with
the following drugs have been reported: Acetazolamide, Amphotericin B,
Corticosteroids, Dichlorphenamide, Diuretics, Methazolamide,
Beta-blockers like acebutolol, atenolol, betaxolol, carteolol, labetalol,
metoprolol, nadolol, oxprenolol, penbutolol, pindolol, propranolol,
sotalol, timolol: Effects of both the drugs may be increased. In
addition, adverse effects may occur if a calcium channel blocker or a
beta-blocker is stopped suddenly after use together. Carbamazepine,
Cyclosporine, Procainamide,Quinidine: Effects of these drugs may be
increased if they are used with calcium channel blockers. Digitalis
glycosides : Effects of these drugs may be increased if they are used
with calcium channel blockers. Disopyramide : Effects of calcium channel
blockers on the heart may be potentiated.

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Adverse
Effect & Precaution




Nausea, constipation,
hypotension, flushing, dizziness, vertigo, pedal oedema, nervousness,
para-esthesias


 

Allergies :
Allergic reaction to verapamil may occur. Pregnancy: Calcium channel
blockers have not been studied in pregnant women. However, studies in
animals have shown that large doses of calcium channel blockers cause
birth defects, prolonged pregnancy, poor bone development, and
stillbirth. Breast-feeding : Verapamil passes into breast milk, but it
has not been reported to cause problems in nursing babies. Older adults:
Elderly people may be especially sensitive to the effects of calcium
channel blockers. This may increase the chance of adverse effects during
treatment.

Pregnancy: Use with Caution

Breast Feeding: Contraindicated

Man: Use with caution

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Brand
available in market












CALAPTIN

 

 

Boehringer
Mannheim

TAB

40mg

10

5.24

TAB

80mg

10

10.38

SR-TAB

120mg

10

15.81

SR-TAB

240mg

10

35.38

INJ

5mg/2ml

5x2ml

8.23

VASOPTEN

 

 

Torrent

TAB

40mg

10

8.86

TAB

80mg

10

17.38

TAB

120mg

10

14.03

 


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Drug Information
  

Pharmacokinetics

Given orally, it has a high hepatic metabolism. Hence a higher dose by oral route should be used than by the I.V route. It is highly protein bound.

TOP
   

Indication & Dosage
 
Oral
PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA, ATRIAL FLUTTER AND FIBRILLATION EXTRA SYSTOLES:
40-80mg t.i.d Max daily dose 480mg.

IV
ACUTE CORONARY INSUFFICIENCY (CORONARY SPASM)
:
IV injections under ECG control: 5-10mg over 2-3 mins. A further 5mg if necessary may be injected 5-10 mins after the firs injection. Children: IV doses. Neonates: 0.75-1mg. Infants: 0.75-2mg 1-5yrs: 2-3mg. 6-15yrs: 2.5-5mg

TOP
   

Action
 
Verapamil inhibits entry of calcium ions into arterial smooth muscle cells as well as the myocytes and conducting tissue. These actions lead to reversal and preventions of coronary artery spasm,  reduction in afterload through peripheral vasodilatation and reduction in ventricular rate in patients with chronic atria flutter or fibrillation and reduction in the ccourence of paroxysmal supraventrucular tachycardia. Verapamil reduces blood pressure, relieves angina and controls arrhythmias.

TOP
   

Interactions
 
Interaction with the following drugs have been reported: Acetazolamide, Amphotericin B, Corticosteroids, Dichlorphenamide, Diuretics, Methazolamide, Beta-blockers like acebutolol, atenolol, betaxolol, carteolol, labetalol, metoprolol, nadolol, oxprenolol, penbutolol, pindolol, propranolol, sotalol, timolol: Effects of both the drugs may be increased. In addition, adverse effects may occur if a calcium channel blocker or a beta-blocker is stopped suddenly after use together. Carbamazepine, Cyclosporine, Procainamide,Quinidine: Effects of these drugs may be increased if they are used with calcium channel blockers. Digitalis glycosides : Effects of these drugs may be increased if they are used with calcium channel blockers. Disopyramide : Effects of calcium channel blockers on the heart may be potentiated.

 TOP
   

Adverse Effect & Precaution

Nausea, constipation, hypotension, flushing, dizziness, vertigo, pedal oedema, nervousness, para-esthesias

 
Allergies : Allergic reaction to verapamil may occur. Pregnancy: Calcium channel blockers have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blockers cause birth defects, prolonged pregnancy, poor bone development, and stillbirth. Breast-feeding : Verapamil passes into breast milk, but it has not been reported to cause problems in nursing babies. Older adults: Elderly people may be especially sensitive to the effects of calcium channel blockers. This may increase the chance of adverse effects during treatment.
Pregnancy: Use with Caution
Breast Feeding: Contraindicated
Man: Use with caution

TOP
   

Brand available in market

CALAPTIN

 

 

Boehringer Mannheim

TAB

40mg

10

5.24

TAB

80mg

10

10.38

SR-TAB

120mg

10

15.81

SR-TAB

240mg

10

35.38

INJ

5mg/2ml

5x2ml

8.23

VASOPTEN

 

 

Torrent

TAB

40mg

10

8.86

TAB

80mg

10

17.38

TAB

120mg

10

14.03

 

TOP
  

By |2022-07-20T16:44:31+00:00July 20, 2022|Uncategorized|Comments Off on Verapamil

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