Drug Information

  













 


Pharmacokinetics


 


After oral administration the absorption is
upredictable. It is metabolised in liver


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Indication
& Dosage


  

ACUTE LEUKAEMIAS,
HODIGKIN’S DISEASEM NONHODGKIN’S LYMPHOMAS, RHABDOMYOSARCOMSA,
NEUROBLASTOMA AND WILM’S TUMOUR: Acute leukaemias:
Children-2mg/m2 or
50mcg/kg weekly, increased by weekly increment of 25mcg/kg to a max of
150mcg/kg. Adult: 1.4mg/m2 or 25mcg-75mcg/kg weekly. Maximum weekly
dose: 2mg. Other malignancies: 25mgc/kg weekly reducing to 5-10mcg/kg
for maintenance.

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Action

 

Vincristine arrests cell division
at the metaphase stage by inhibiting microtubule formation in the
mitotic spindle

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Interactions

 

Digoxin: Decreased plasma
digoxin levels and renal excretion.

L-asparaginase: Hepatic clearance of vincristine is reduced if L-asparaginase
is reduced if L-asparaginase is administered first. Thus to minimise
toxicity, vincristine shoul be given 12 to 24 hours before administerin
L-asparaginase

Mitomycin-C: Acute pulmonary plasma levels.

Phenytoin: Reduced phenytoin plasma levels.

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Adverse
Effect & Precaution


 

Local reaction if extravasation occurs, constialopecia, bone marrow
depression, peripheral neuropathy. In appropriate ADH secretion.
Shortness of breath, bronchospasm, hypo or hypertension.



Precaution: Infection neuromuscular
disease, Leucopenia, pulmonary disorders, leukaemia, radiation therapy,
extravasation, concomitant neurotoxic drug. Eye Contact, concurrent
vaccination.

Pregnancy: Contraindication.

Breast Feeding: Use with caution.

Man: Use with caution.


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Brand
available in market








CYTOCRISTIN     Cipla
INJ 1mg/ml 1ml 45.00
ONCOCRISTIN-AQ     T.D.P.L
INJ 1mg/ml 1ml 46.79
VINCRISTINE     Biochem
INJ 1mg VIAL 47.75

 

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Drug Information
  

 
Pharmacokinetics
 
After oral administration the absorption is upredictable. It is metabolised in liver

TOP
   

Indication & Dosage
  
ACUTE LEUKAEMIAS, HODIGKIN’S DISEASEM NONHODGKIN’S LYMPHOMAS, RHABDOMYOSARCOMSA, NEUROBLASTOMA AND WILM’S TUMOUR: Acute leukaemias:
Children-2mg/m2 or 50mcg/kg weekly, increased by weekly increment of 25mcg/kg to a max of 150mcg/kg. Adult: 1.4mg/m2 or 25mcg-75mcg/kg weekly. Maximum weekly dose: 2mg. Other malignancies: 25mgc/kg weekly reducing to 5-10mcg/kg for maintenance.

   TOP
   

Action
 
Vincristine arrests cell division at the metaphase stage by inhibiting microtubule formation in the mitotic spindle

 TOP
   

Interactions
 
Digoxin: Decreased plasma digoxin levels and renal excretion.
L-asparaginase: Hepatic clearance of vincristine is reduced if L-asparaginase is reduced if L-asparaginase is administered first. Thus to minimise toxicity, vincristine shoul be given 12 to 24 hours before administerin L-asparaginase
Mitomycin-C: Acute pulmonary plasma levels.
Phenytoin: Reduced phenytoin plasma levels.

  TOP
   

Adverse Effect & Precaution
 
Local reaction if extravasation occurs, constialopecia, bone marrow depression, peripheral neuropathy. In appropriate ADH secretion. Shortness of breath, bronchospasm, hypo or hypertension.

Precaution: Infection neuromuscular disease, Leucopenia, pulmonary disorders, leukaemia, radiation therapy, extravasation, concomitant neurotoxic drug. Eye Contact, concurrent vaccination.
Pregnancy: Contraindication.
Breast Feeding: Use with caution.
Man: Use with caution.

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Brand available in market

CYTOCRISTIN

 

 

Cipla

INJ

1mg/ml

1ml

45.00

ONCOCRISTIN-AQ

 

 

T.D.P.L

INJ

1mg/ml

1ml

46.79

VINCRISTINE

 

 

Biochem

INJ

1mg

VIAL

47.75

 

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By |2022-07-20T16:44:29+00:00July 20, 2022|Uncategorized|Comments Off on Vincristine

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