Drug Information


    

         











Pharmacokinetics


 

wafarin is absorbed nearly
cmpletely after oral administration. It is highly bound to plasma
proteins and it crosses the placental barrier.

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Indication
& Dosage




Plumonary embolism, venous
thrombosis, atrial fibrilaation with embolisation.

Dosage: Adults: 10-15mg daily. Adust dosage according to test
results(P.T.)

Children: Not recommended.

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Interactions

 

Drugs that increase the
anticoagulant effect of warfarin by unknown or complicated mechanisms:
Acetaminophen, Beta blockers, Androgens, Cyclo-phosphamide, Disulfiram,
Erythromycin, fluconazole, Gemfibrozil, Glucagon, Hydantoins,
Propoxyphene, Isoniazid, Miconazole, Ketoconazole Quinolones,
sulfonamides, Tamoxifen, Thyroid hormones. Drugs that increase the
anticoagulant effect of warfarin by inhibition of hepatic metabolism:
Amiodarone, Chloramphenicol, Ifosamide, Cimetidine, Lovastatin
Metronidazole, Omeprazole, Phenylbutazone, Propafenone, Quinine,
Quinidine, sulpamethoxa zole-trimethoprim, sulfinpyrazone.

Drugs that enhance efficacy of warfarin by displacement from binding
sites: Chloral hydrate, Loop diuretics, Nalidixic acid. Drugs that
enhance anticoagulant effects of warfarin due to interference with Vit.
K: Aminoglycosides, Mineral oil, Tetracylines, Vit E.

Drugs that enhance efficacy of warfarin due to effects on platelet
function : Cephalosporins, diflusinal, NSAIDS, Penicillins, Salicylates.

Drugs that decrease anticoagulant effects of warfarin due to induction
of the hepatic microsomal enzymes: Aminoglutethimide, Barbiturates,
Carbamazepine, Rifampicin, Glutethimide, Etretinate.

Durgs that decrease the anticoaguant effect of warfarin due to to
various mechanism; Cholestyramine, oral contraceptives, Estrogens,
Thiopurines, Spironolactone, Vitamin K, Thiazide diuretics.

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Adverse
Effect & Precaution




Haemorrhage, rash, alopecia,
diarrhoea, hepatic dysfunction, nausea, vomiting and pancreatitis.

TOP

   

Brand
available in market





 

 

 

 

UNIWARFIN

 

 

Unisearch

TAB

10

5mg

17.60

TOP

  






      

   
Drug Information
    

         

Pharmacokinetics
 
wafarin is absorbed nearly cmpletely after oral administration. It is highly bound to plasma proteins and it crosses the placental barrier.

TOP
   

Indication & Dosage

Plumonary embolism, venous thrombosis, atrial fibrilaation with embolisation.
Dosage: Adults: 10-15mg daily. Adust dosage according to test results(P.T.)
Children: Not recommended.

TOP
   

Interactions
 
Drugs that increase the anticoagulant effect of warfarin by unknown or complicated mechanisms: Acetaminophen, Beta blockers, Androgens, Cyclo-phosphamide, Disulfiram, Erythromycin, fluconazole, Gemfibrozil, Glucagon, Hydantoins, Propoxyphene, Isoniazid, Miconazole, Ketoconazole Quinolones, sulfonamides, Tamoxifen, Thyroid hormones. Drugs that increase the anticoagulant effect of warfarin by inhibition of hepatic metabolism: Amiodarone, Chloramphenicol, Ifosamide, Cimetidine, Lovastatin Metronidazole, Omeprazole, Phenylbutazone, Propafenone, Quinine, Quinidine, sulpamethoxa zole-trimethoprim, sulfinpyrazone.
Drugs that enhance efficacy of warfarin by displacement from binding sites: Chloral hydrate, Loop diuretics, Nalidixic acid. Drugs that enhance anticoagulant effects of warfarin due to interference with Vit. K: Aminoglycosides, Mineral oil, Tetracylines, Vit E.
Drugs that enhance efficacy of warfarin due to effects on platelet function : Cephalosporins, diflusinal, NSAIDS, Penicillins, Salicylates.
Drugs that decrease anticoagulant effects of warfarin due to induction of the hepatic microsomal enzymes: Aminoglutethimide, Barbiturates, Carbamazepine, Rifampicin, Glutethimide, Etretinate.
Durgs that decrease the anticoaguant effect of warfarin due to to various mechanism; Cholestyramine, oral contraceptives, Estrogens, Thiopurines, Spironolactone, Vitamin K, Thiazide diuretics.

TOP
   

Adverse Effect & Precaution

Haemorrhage, rash, alopecia, diarrhoea, hepatic dysfunction, nausea, vomiting and pancreatitis.

TOP
   

Brand available in market

 

 

 

 

UNIWARFIN

 

 

Unisearch

TAB

10

5mg

17.60

TOP
  

By |2022-07-20T16:44:28+00:00July 20, 2022|Uncategorized|Comments Off on Wafarin

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