wafarin is absorbed nearly cmpletely after oral administration. It is highly bound to plasma proteins and it crosses the placental barrier.
Plumonary embolism, venous thrombosis, atrial fibrilaation with embolisation.
Dosage: Adults: 10-15mg daily. Adust dosage according to test results(P.T.)
Children: Not recommended.
Drugs that increase the anticoagulant effect of warfarin by unknown or complicated mechanisms: Acetaminophen, Beta blockers, Androgens, Cyclo-phosphamide, Disulfiram, Erythromycin, fluconazole, Gemfibrozil, Glucagon, Hydantoins, Propoxyphene, Isoniazid, Miconazole, Ketoconazole Quinolones, sulfonamides, Tamoxifen, Thyroid hormones. Drugs that increase the anticoagulant effect of warfarin by inhibition of hepatic metabolism: Amiodarone, Chloramphenicol, Ifosamide, Cimetidine, Lovastatin Metronidazole, Omeprazole, Phenylbutazone, Propafenone, Quinine, Quinidine, sulpamethoxa zole-trimethoprim, sulfinpyrazone.
Drugs that enhance efficacy of warfarin by displacement from binding sites: Chloral hydrate, Loop diuretics, Nalidixic acid. Drugs that enhance anticoagulant effects of warfarin due to interference with Vit. K: Aminoglycosides, Mineral oil, Tetracylines, Vit E.
Drugs that enhance efficacy of warfarin due to effects on platelet function : Cephalosporins, diflusinal, NSAIDS, Penicillins, Salicylates.
Drugs that decrease anticoagulant effects of warfarin due to induction of the hepatic microsomal enzymes: Aminoglutethimide, Barbiturates, Carbamazepine, Rifampicin, Glutethimide, Etretinate.
Durgs that decrease the anticoaguant effect of warfarin due to to various mechanism; Cholestyramine, oral contraceptives, Estrogens, Thiopurines, Spironolactone, Vitamin K, Thiazide diuretics.
Effect & Precaution
Haemorrhage, rash, alopecia, diarrhoea, hepatic dysfunction, nausea, vomiting and pancreatitis.