Drug Information

 

 






Acenocoumarol

  

Pharmacokinetics
| Indication
& Dosage
| Action
| Interactions 

Adverse
Effect & Precautions
|
Brands available in Market

 









  

Pharmacokinetics


 

Acenocoumarol is absorbed
nearly completely after oral administration. It is highly bound to
plasma proteins and it crosses the placental barrier.

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Indication
& Dosage




Thromboembolism Atrial
fibrillation, pulmonary embolism, RHB, TIA, Prophylaxis after insertion
of prosthetic heart valves.


Dosage:
Adults: Initial loading dose: 16-28. 2nd day: 8-16mg/day

Maint: 2-10mg/day Adjust dosages as per Prothrombin Time.

Children: Not recommended.

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Action



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Interactions



Drugs which enhance efficay
of acenocoumarol: NSAID’s, Amiodarone, Antibacterial agents (Cotrimoxazole
Cephalosporins, Erythromycin, Quinolone antibiotics, Chloramphenicol,
Doxycycline, INH, Neomycin), Cimetidine, Allopurinol, Diuretics and Oral
anticogulants.

Drugs which decrease efficacy: Bismuth bicarbonate, Rifampicin,
Barbiturates, Griseofulvin, Magnesium.

Oral hypoglycemic agents: Efficacy of these enhanced.

VIT.K: Reverses effects.

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Adverse
Effect & Precaution


 

Haemorrhage, rash, alopecia,
diarrhoea, hepatic dysfuntion, nausea, vomiting and pancreatitis.

Precaution: Hepatic or renal disease, recent surgeries.

Pregnancy: Contraindicated.

Breast Feeding: Use with Caution.

Man: May be used.

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Brand
available in market


 








       
ACENOCOUMAROL     SPPL
TAB 10 1mg 19.97
TAB 10 2mg 28.04
TAB 10 4mg 40.60
       


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Drug Information
 

 

  
Pharmacokinetics

 
Acenocoumarol is absorbed nearly completely after oral administration. It is highly bound to plasma proteins and it crosses the placental barrier.

Top 

 

Indication & Dosage

Thromboembolism Atrial fibrillation, pulmonary embolism, RHB, TIA, Prophylaxis after insertion of prosthetic heart valves.
Dosage: Adults: Initial loading dose: 16-28. 2nd day: 8-16mg/day
Maint: 2-10mg/day Adjust dosages as per Prothrombin Time.
Children: Not recommended.

Top 

 

Interactions

Drugs which enhance efficay of acenocoumarol: NSAID’s, Amiodarone, Antibacterial agents (Cotrimoxazole Cephalosporins, Erythromycin, Quinolone antibiotics, Chloramphenicol, Doxycycline, INH, Neomycin), Cimetidine, Allopurinol, Diuretics and Oral anticogulants.
Drugs which decrease efficacy: Bismuth bicarbonate, Rifampicin, Barbiturates, Griseofulvin, Magnesium.
Oral hypoglycemic agents: Efficacy of these enhanced.
VIT.K: Reverses effects.

Top

 

Adverse Effect & Precaution
 
Haemorrhage, rash, alopecia, diarrhoea, hepatic dysfuntion, nausea, vomiting and pancreatitis.
Precaution: Hepatic or renal disease, recent surgeries.
Pregnancy: Contraindicated.
Breast Feeding: Use with Caution.
Man: May be used.

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Brand available in market
 

 

 

 

 

ACENOCOUMAROL

 

 

SPPL

TAB

10

1mg

19.97

TAB

10

2mg

28.04

TAB

10

4mg

40.60

 

 

 

 

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By |2022-07-20T16:44:28+00:00July 20, 2022|Uncategorized|Comments Off on Acenocoumarol

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