Drug Information

 

 





 











Pharmacokinetics


 

Acyclovir when given orally
is poorly absorbed with bio-availability of 15% to 30%. Its level in the
CSF is 50% of that in the plasma. When given IV it raises the serum
creatinine and urea level. It penetrates the cornea well. It is excreted
unchanged in urine by glomerular filtration and tubular secretion.
Plasma half life is 2-3 hours.

Top

 

Indication
& Dosage


 

Oral :


Herpes simplex initial therapy : 200mg 5 times daily for 10
days. 



Herpes simplex Chronic suppressive therapy : 200-400mg 2 to 4 times
daily for 12 months. Re-evaluate before continuation of therapy.



Herpes Zoster : 800mg 5 times daily at 4 hrs intervals for
7-10days. 



Varicela Zoster : 20mg/kg (not more than 800mg) 4 times daily for 5
days. 



Children : Under 2 years should be given half of these doses. 



Elderly : Dosage may also be reduced as required.




IV Infusion :

Herpes Simplex Encephalitics :
10mg/kg infused at constant rate over 1
hour every 8 hrs for 10 days. 



Children : Under 12 yrs 500mg/m2 infused over 1 hr. every 8 hrs of 10
days.




Varicella Zoster Infections :
10mg/kg infused at constant rate over 1 hour
every 8 hrs. for 7 days  in adults with normal renal function.



Children : 6 months to 12 years 500mg/m2 infused over 1hr. every 8
hrs. for 7 days.



Severe Episodes of Herpes Genitalis : 5mg/kg infused over 1 hr. every
8 hrs. for 5 days in adults. 



Children : Under 12 years 250mg/m2 infused over 1 hr. every 8 hours
for 5 days.



Note : In patients with acute or chronic renal impairment
acyclovir dosage should be based on estimated creatinine clearance(cc).

Top

  

Action



Acyclovir exerts a highly sensitive inhibitory action
against herpes simplex types 1 and 2, Varicella-Zoster virus, Epstein-Bar
virus and cytomegalovirus. The enzymes thymidine Kinases(TK) in
virus-infected but not uninfected cells initiates the activation of
acyclovir into the tirphosphate. The interferes with viral DNA polymerase
and inhibits viral duplication.

Top

 
 

Interaction

  

Drugs like Carmustine,
Cisplatin, Cyclosporine, Deferoxamine, Gold salts, Lithium, Methotrexate,
Penicillamine, Plicamycin, Streptozocin and Tiopronin when used along
with Acyclovir may increase the chance for adverse effects, especially
when renal disease is present.

Top

  

Adverse
Effect & Precaution


 

Superficial punctate
keratopathy, stinging sensation in the eyes.

  


In renal disease there may be an
increase in the blood levels of acyclovir thus increasing the chance of
adverse effects. In those with Nervous system disorders Acyclovir when
given IV may increase the chance for neurological side
effects[tremors,hallucinations,convulsions and coma]. Special
precautions should be taken in pregnancy.

Top

   

Brands
available in market


































 

Acivir DT

 

 

Cipla

DIS-TAB

200mg

10

54.50

DIS-TAB

400mg

5

52.00

DIS-TAB

800mg

5

93.50

Cyclovir

 

 

Cadila Healthcare

TAB

200mg

58

184.25

Herperax

 

 

Micro Labs

Cream

5% w/w

5g

36.00

TAB

200mg

10

50.00

TAB

200mg

3

7.60

Herpex

 

 

Torrent

TAB

200mg

10

65.90

Hevir

 

 

SOL

TAB

200mg

10

100.00

Lovir

 

 

Eli Lilly Ranbaxy

TAB

200mg

5

60.00

TAB

400mg

5

108.00

TAB

800mg

5

198.00

Ocuvir

 

 

FDC

SUSP

400mg/5ml

60ml

89.90

TAB

200mg

10

52.50

TAB

400mg

5

49.50

TAB

800mg

5

89.50

Ridoherp

 

 

RPG

TAB

200mg

10

60.00

VIR INJ

 

 

Troikaa

INJ

250.0mg

VIAL

400.00

Zovirax

 

 

Burroughs Wellcome

TAB

200mg

25

383.75

Zovirax I.V.

 

 

Burroughs Wellcome

INJ-IV

250mg

VIAL

600.00


  Top


 

 



 

 

 
Drug Information
 

 

 


Pharmacokinetics

 
Acyclovir when given orally is poorly absorbed with bio-availability of 15% to 30%. Its level in the CSF is 50% of that in the plasma. When given IV it raises the serum creatinine and urea level. It penetrates the cornea well. It is excreted unchanged in urine by glomerular filtration and tubular secretion. Plasma half life is 2-3 hours.

Top

 

Indication & Dosage
 
Oral :
Herpes simplex initial therapy : 200mg 5 times daily for 10 days. 

Herpes simplex Chronic suppressive therapy : 200-400mg 2 to 4 times daily for 12 months. Re-evaluate before continuation of therapy.

Herpes Zoster : 800mg 5 times daily at 4 hrs intervals for 7-10days. 

Varicela Zoster : 20mg/kg (not more than 800mg) 4 times daily for 5 days. 

Children : Under 2 years should be given half of these doses. 

Elderly : Dosage may also be reduced as required.

IV Infusion :
Herpes Simplex Encephalitics :
10mg/kg infused at constant rate over 1 hour every 8 hrs for 10 days. 

Children : Under 12 yrs 500mg/m2 infused over 1 hr. every 8 hrs of 10 days.

Varicella Zoster Infections : 10mg/kg infused at constant rate over 1 hour every 8 hrs. for 7 days  in adults with normal renal function.

Children : 6 months to 12 years 500mg/m2 infused over 1hr. every 8 hrs. for 7 days.

Severe Episodes of Herpes Genitalis : 5mg/kg infused over 1 hr. every 8 hrs. for 5 days in adults. 

Children : Under 12 years 250mg/m2 infused over 1 hr. every 8 hours for 5 days.

Note : In patients with acute or chronic renal impairment acyclovir dosage should be based on estimated creatinine clearance(cc).

Top

  

Action

Acyclovir exerts a highly sensitive inhibitory action against herpes simplex types 1 and 2, Varicella-Zoster virus, Epstein-Bar virus and cytomegalovirus. The enzymes thymidine Kinases(TK) in virus-infected but not uninfected cells initiates the activation of acyclovir into the tirphosphate. The interferes with viral DNA polymerase and inhibits viral duplication.

Top

   

Interaction
  
Drugs like Carmustine, Cisplatin, Cyclosporine, Deferoxamine, Gold salts, Lithium, Methotrexate, Penicillamine, Plicamycin, Streptozocin and Tiopronin when used along with Acyclovir may increase the chance for adverse effects, especially when renal disease is present.

Top

  

Adverse Effect & Precaution
 
Superficial punctate keratopathy, stinging sensation in the eyes.
  
In renal disease there may be an increase in the blood levels of acyclovir thus increasing the chance of adverse effects. In those with Nervous system disorders Acyclovir when given IV may increase the chance for neurological side effects[tremors,hallucinations,convulsions and coma]. Special precautions should be taken in pregnancy.

Top

   

 

Acivir DT

 

 

Cipla

DIS-TAB

200mg

10

54.50

DIS-TAB

400mg

5

52.00

DIS-TAB

800mg

5

93.50

Cyclovir

 

 

Cadila Healthcare

TAB

200mg

58

184.25

Herperax

 

 

Micro Labs

Cream

5% w/w

5g

36.00

TAB

200mg

10

50.00

TAB

200mg

3

7.60

Herpex

 

 

Torrent

TAB

200mg

10

65.90

Hevir

 

 

SOL

TAB

200mg

10

100.00

Lovir

 

 

Eli Lilly Ranbaxy

TAB

200mg

5

60.00

TAB

400mg

5

108.00

TAB

800mg

5

198.00

Ocuvir

 

 

FDC

SUSP

400mg/5ml

60ml

89.90

TAB

200mg

10

52.50

TAB

400mg

5

49.50

TAB

800mg

5

89.50

Ridoherp

 

 

RPG

TAB

200mg

10

60.00

VIR INJ

 

 

Troikaa

INJ

250.0mg

VIAL

400.00

Zovirax

 

 

Burroughs Wellcome

TAB

200mg

25

383.75

Zovirax I.V.

 

 

Burroughs Wellcome

INJ-IV

250mg

VIAL

600.00

  Top

 

 

 

By |2022-07-20T16:42:47+00:00July 20, 2022|Uncategorized|Comments Off on Acyclovir

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