Drug Information

 

 






 










Pharmacokinetics


 

On Intravenous administration
it is removed from the circulation very rapidly. It is extensively
metabolised by almost all cells of the body to adenosine monphosphate
and finally to xanthine. Hepatic or renal diseases and old age do not
affect kinetics of adenosine.

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Indication
& Dosage




Treatment of paroxysmal
supraventricular tachycardia (PAVT). Diagnosis of rentrant atrial and
ventricular tachycardias.

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Action

Found naturally in all cells of the body. It slows conduction time
through the AV node, interrupts the reentry pathways through the AV
node, and restores normal sinus rhythm in paroxysmal supraventricular
Competitively antagonized by caffeine, theophylline, and dipyridamole. Onset,
after IV: 34 sec. t1/2: Less than 10 sec (taken up
by erythrocytes and vascular endothelial cells). Duration: 1-2
min. Exogenous adenosine becomes part of the body pool and is
metabolized mainly to inosine and AMP.

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Interactions

Carbamazepine /
Degree of heart block

Caffeine / Competitively antagonizes effect of adenosine


Digitalis / Possibility of ventricular fibrillation (rare)


Dipyridamole /
Effect of adenosine


Theophylline / Competitively antagonizes effect of adenosine



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Adverse
Effect & Precaution

Facial flushing,
headache, sweating, Palpitation, chest pain, hypotension. Dyspnoea,
lighteadedness numbness, tingling in arms, blurred vision, burning
sensation heaviness in arms, neck and back pain, metallic taste,
tightness in throat.

Precaution: Patients with atrial fibrillation, flutter and an accessory
by-pass tract may develop increased conduction down the anomalous
pathway. Adenosine should only be used during pregnancy when absolutely
necessary. Patients who develop high-level AV  block at a
particular dose should not be given ther dosage increments.

Pregnancy: Use if risk outweigh benefit.

Breast Feeding: Contraindicated.

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Brand
available in market









       
ADENOCOR     Sanofi
Torretn
INJ 2ml 3mg/ml  
ADENOJECT     Sun
Pharma
INJ 2ml 3mg/ml  
       



 



 

 

 
Drug Information
 

 

 


Pharmacokinetics

 
On Intravenous administration it is removed from the circulation very rapidly. It is extensively metabolised by almost all cells of the body to adenosine monphosphate and finally to xanthine. Hepatic or renal diseases and old age do not affect kinetics of adenosine.

Top

  

Indication & Dosage

Treatment of paroxysmal supraventricular tachycardia (PAVT). Diagnosis of rentrant atrial and ventricular tachycardias.

Top

   

Action

Found naturally in all cells of the body. It slows conduction time through the AV node, interrupts the reentry pathways through the AV node, and restores normal sinus rhythm in paroxysmal supraventricular Competitively antagonized by caffeine, theophylline, and dipyridamole. Onset, after IV: 34 sec. t1/2: Less than 10 sec (taken up by erythrocytes and vascular endothelial cells). Duration: 1-2 min. Exogenous adenosine becomes part of the body pool and is metabolized mainly to inosine and AMP.

Top

 

Interactions

Carbamazepine / Degree of heart block Caffeine / Competitively antagonizes effect of adenosine Digitalis / Possibility of ventricular fibrillation (rare) Dipyridamole / Effect of adenosine Theophylline / Competitively antagonizes effect of adenosine

Top

 

Adverse Effect & Precaution

Facial flushing, headache, sweating, Palpitation, chest pain, hypotension. Dyspnoea, lighteadedness numbness, tingling in arms, blurred vision, burning sensation heaviness in arms, neck and back pain, metallic taste, tightness in throat.
Precaution: Patients with atrial fibrillation, flutter and an accessory by-pass tract may develop increased conduction down the anomalous pathway. Adenosine should only be used during pregnancy when absolutely necessary. Patients who develop high-level AV  block at a particular dose should not be given ther dosage increments.
Pregnancy: Use if risk outweigh benefit.
Breast Feeding: Contraindicated.

Top

  

Brand available in market

 

 

 

 

ADENOCOR

 

 

Sanofi Torretn

INJ

2ml

3mg/ml

 

ADENOJECT

 

 

Sun Pharma

INJ

2ml

3mg/ml

 

 

 

 

 

 

 

By |2022-07-20T16:44:27+00:00July 20, 2022|Uncategorized|Comments Off on Adenosine

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