Drug Information

 






Alfa
Calcidol

  



















 

Pharmacokinetics



After oral administration it
is abosrbed in the small intestine and undergoes rapid metabolis to
1,25(OH)2D3 AND further distribution to bone and intestine is nearly
similar to its physiological distribution.

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Indication
& Dosage

 

Oral : 

GENERAL DOSAGE : Adults, children, over 20kg : 1mcg/day increments by
0.25-0.5mcg upto 1-3mcg/day. 

Elderly : 0.5mcg/day. Children under 20kg : 0.05mcg/kg/day. Monitor
calcium levels, serum alkaline phosphatase.



RENAL OSTEODYSTORPHY : 0.04-0.08mcg/kg/day.



OSTEOPOROSIS : 0.5mcg/kg/day increased upto 1mcg/day.



HYPOPARATHYRODISM : Low plasma calcium levels can be corrected rapidly
with 3-5mcg along with calcium supplements..


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Action

Alfa Calcidol is a precusor of the active
calcitrol. Alfa
calcidol does not require renal Hydroxylation but requires
25-hydroxyaltion in the liver for conversion to calcitriol. Actions are
the conversion to calcitriol. Actions are the same as Vitamin D group.

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Interactions



Digitalis Preparations:
Cardiac arrhythmias precipitated.

Thiazide Diuretics: Hypercalcaemic response enhanced. Barbiturates &
other enzyme inducing anticonvulsants: Reduce efficacy.

Mineral Oil: Prolonged use reduce Efficacy.

Cholestyramine, cholestipol Sucralfate, Aluminium based Antacids: Reduce
Efficacy- by decreasing absorption of alfacalcidol

Magnesium based Antacids or Laxatives: Hypermagnesaemia in those on
chronic renal dialysis. 

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Adverse
Effect & Precaution


Hypercalcaemia and
hyperphophataemia.

Precaution: Hypercalciuria, renal
impairment.

Pregnancy: Use with caution

Breast Feeding: Use with caution

Man: Use with caution

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Brands
available in market




 



















Alfacal

Macleods
CAPS 0.25mcg 10 49.30
Alfacip

Cipla
CAPS 0.25mcg 10 50.00
CAPS 1mcg 10 190.00
Alpha D3

Biddle Sawyer
CAPS 0.25mcg 10 104.00
CAPS 1mcg 10 265.00
Alphadol

Panacea
CAPS 0.25mcg 3×10 48.50
CAPS 1mcg 3×10 169.00
CAPS 1mcg 3×10 169300
Calcirol

Cadila Pharma
GRANULES 1g sachet 6.60
One Alpha

Croslands
CAPS 0.25mcg 3×10 210.00
CAPS 1mcg 10 180.00


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Drug Information
 


Alfa Calcidol
  

 
Pharmacokinetics

After oral administration it is abosrbed in the small intestine and undergoes rapid metabolis to 1,25(OH)2D3 AND further distribution to bone and intestine is nearly similar to its physiological distribution.

Top 

Indication & Dosage
 
Oral : 
GENERAL DOSAGE : Adults, children, over 20kg : 1mcg/day increments by 0.25-0.5mcg upto 1-3mcg/day. 
Elderly : 0.5mcg/day. Children under 20kg : 0.05mcg/kg/day. Monitor calcium levels, serum alkaline phosphatase.

RENAL OSTEODYSTORPHY : 0.04-0.08mcg/kg/day.

OSTEOPOROSIS : 0.5mcg/kg/day increased upto 1mcg/day.

HYPOPARATHYRODISM : Low plasma calcium levels can be corrected rapidly with 3-5mcg along with calcium supplements..

Top

Action

Alfa Calcidol is a precusor of the active calcitrol. Alfa calcidol does not require renal Hydroxylation but requires 25-hydroxyaltion in the liver for conversion to calcitriol. Actions are the conversion to calcitriol. Actions are the same as Vitamin D group.

Top

Interactions

Digitalis Preparations: Cardiac arrhythmias precipitated.
Thiazide Diuretics: Hypercalcaemic response enhanced. Barbiturates & other enzyme inducing anticonvulsants: Reduce efficacy.
Mineral Oil: Prolonged use reduce Efficacy.
Cholestyramine, cholestipol Sucralfate, Aluminium based Antacids: Reduce Efficacy- by decreasing absorption of alfacalcidol
Magnesium based Antacids or Laxatives: Hypermagnesaemia in those on chronic renal dialysis. 

Top 

Adverse Effect & Precaution
Hypercalcaemia and hyperphophataemia.
Precaution: Hypercalciuria, renal impairment.
Pregnancy: Use with caution
Breast Feeding: Use with caution
Man: Use with caution

Top  

 

Alfacal

Macleods

CAPS

0.25mcg

10

49.30

Alfacip

Cipla

CAPS

0.25mcg

10

50.00

CAPS

1mcg

10

190.00

Alpha D3

Biddle Sawyer

CAPS

0.25mcg

10

104.00

CAPS

1mcg

10

265.00

Alphadol

Panacea

CAPS

0.25mcg

3×10

48.50

CAPS

1mcg

3×10

169.00

CAPS

1mcg

3×10

169300

Calcirol

Cadila Pharma

GRANULES

1g

sachet

6.60

One Alpha

Croslands

CAPS

0.25mcg

3×10

210.00

CAPS

1mcg

10

180.00

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By |2022-07-20T16:44:55+00:00July 20, 2022|Uncategorized|Comments Off on Alfa Calcidol

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