Drug Information

 





Alprazolam

 













 

Pharmacokinetics

It is
absorbed from the proximal small intestine. It is extensively
distributed in the body. It is transformed to clinically active
metabolites. It has a moderately long 1/2 life and may persist in the
body.

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Indiacation
& Dosage

ANXIETY
DISORDERS
: Start with 0.25-0.5mg t.i.d and increased at intervals of 3-4
days upto max daily dose of 4mg.


PANIC DISORDER
: Start with 0.5mg t.i.d. Increase by 1mg/day at intervals
of 3-4days. Dose reduction should be attempted at appropriate intervals.
The usual daily dose has been 4-6mg though upto 7-10mg/day have been
required in some patients.

Depression: Initially 0.5mg t.i.d Increased as described above upto
4mg/day. Higher doses may be required in some patient

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Action

Alprazolam has
anxiolytic, muscle-relaxant, anti-convulsant, antidepressant and
sleep-modifying effects. It binds with specific binding sites throughout
the CNS. The site is a receptor complex consisting of a GABA ergic
receptor and a chloride channel. Alprazolam potentiates the neuronal
inhibition caused by GABA(GAMMA AMINOBUTYRIC ACID)

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Interactions

Combination of
alprazolam with alcohol and barbiturates can be potentially dangerous
.They produce synergistic CNS depression.

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Adverse
Effect & Precaution




Anarexia, nausea, drowsiness,
hypersensitivity reactions, pruritis, loss of memory, loss of
co-ordination, trasient amnesia, slurred speech.

Withdrawal
of drug should be gradual.Special precautions should be taken in
geriatric or debiliated patients, epilepsy,impaired hepatic and renal
function.

Pregnancy: Contraindicated

Breast Feeding: Contraindicated.

Man: May be give in reduced.

Top

Brands
availble in Market




 


















































Alpam

Saga Labs

TAB

0.25 mg

10

6.50

TAB

0.5 mg

10

11.10

Alpraquil

Lupin

TAB

0.25 mg

10

7.59

TAB

0.50 mg

10

14.17

TAB

1mg

10

19.74

Alprax

Torrent

TAB

0.25 mg

10

7.50

TAB

0.50 mg

10

14.00

TAB

1mg

10

19.90

Alprose

Pharmasynth

TAB

0.25 mg

10

3.00

TAB

0.5 mg

10

4.50

Alzam

Arvind Remedies

TAB

0.25 mg

10

6.25

TAB

0.5 mg

10

11.25

TAB

1 mg

10

15.00

Alzolam

Sun Pharma

TAB

0.25 mg

10

8.00

TAB

0.5 mg

10

15.50

TAB

1 mg

10

23.00

Alzomax

Kamron

TAB

0.25 mg

10

7.45

TAB

0.5 mg

10

14.85

TAB

1 mg

10

24.95

Alzopax

LA Pharma

TAB

0.25 mg

10

7.50

TAB

0.5 mg

10

13.50

TAB

1 mg

10

15.80

Anax

Cachet Pharma

TAB

0.25 mg

10

9.00

TAB

0.5 mg

10

14.50

TAB

1 mg

10

16.40

Anxigon

Blue Cross

TAB

0.25 mg

10

8.00

TAB

0.5 mg

10

12.00

TAB

1 mg

10

17.00

Anxit

Micro Labs

TAB

0.25 mg

10

8.50

TAB

0.5 mg

10

13.80

TAB

1 mg

10

18.00

Anzilum

Cadila Pharma

TAB

0.25 mg

10

3.95

TAB

0.5 mg

10

7.00

TAB

1 mg

10

11.00




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Drug Information
 


Alprazolam
 

 

Pharmacokinetics

It is absorbed from the proximal small intestine. It is extensively distributed in the body. It is transformed to clinically active metabolites. It has a moderately long 1/2 life and may persist in the body.

Top

Indiacation & Dosage

ANXIETY DISORDERS: Start with 0.25-0.5mg t.i.d and increased at intervals of 3-4 days upto max daily dose of 4mg.
PANIC DISORDER: Start with 0.5mg t.i.d. Increase by 1mg/day at intervals of 3-4days. Dose reduction should be attempted at appropriate intervals. The usual daily dose has been 4-6mg though upto 7-10mg/day have been required in some patients.
Depression: Initially 0.5mg t.i.d Increased as described above upto 4mg/day. Higher doses may be required in some patient

Top

Action

Alprazolam has anxiolytic, muscle-relaxant, anti-convulsant, antidepressant and sleep-modifying effects. It binds with specific binding sites throughout the CNS. The site is a receptor complex consisting of a GABA ergic receptor and a chloride channel. Alprazolam potentiates the neuronal inhibition caused by GABA(GAMMA AMINOBUTYRIC ACID)

Top

Interactions

Combination of alprazolam with alcohol and barbiturates can be potentially dangerous .They produce synergistic CNS depression.

Top

Adverse Effect & Precaution

Anarexia, nausea, drowsiness, hypersensitivity reactions, pruritis, loss of memory, loss of co-ordination, trasient amnesia, slurred speech.

Withdrawal of drug should be gradual.Special precautions should be taken in geriatric or debiliated patients, epilepsy,impaired hepatic and renal function.
Pregnancy: Contraindicated
Breast Feeding: Contraindicated.
Man: May be give in reduced.

Top

 

Alpam

Saga Labs

TAB

0.25 mg

10

6.50

TAB

0.5 mg

10

11.10

Alpraquil

Lupin

TAB

0.25 mg

10

7.59

TAB

0.50 mg

10

14.17

TAB

1mg

10

19.74

Alprax

Torrent

TAB

0.25 mg

10

7.50

TAB

0.50 mg

10

14.00

TAB

1mg

10

19.90

Alprose

Pharmasynth

TAB

0.25 mg

10

3.00

TAB

0.5 mg

10

4.50

Alzam

Arvind Remedies

TAB

0.25 mg

10

6.25

TAB

0.5 mg

10

11.25

TAB

1 mg

10

15.00

Alzolam

Sun Pharma

TAB

0.25 mg

10

8.00

TAB

0.5 mg

10

15.50

TAB

1 mg

10

23.00

Alzomax

Kamron

TAB

0.25 mg

10

7.45

TAB

0.5 mg

10

14.85

TAB

1 mg

10

24.95

Alzopax

LA Pharma

TAB

0.25 mg

10

7.50

TAB

0.5 mg

10

13.50

TAB

1 mg

10

15.80

Anax

Cachet Pharma

TAB

0.25 mg

10

9.00

TAB

0.5 mg

10

14.50

TAB

1 mg

10

16.40

Anxigon

Blue Cross

TAB

0.25 mg

10

8.00

TAB

0.5 mg

10

12.00

TAB

1 mg

10

17.00

Anxit

Micro Labs

TAB

0.25 mg

10

8.50

TAB

0.5 mg

10

13.80

TAB

1 mg

10

18.00

Anzilum

Cadila Pharma

TAB

0.25 mg

10

3.95

TAB

0.5 mg

10

7.00

TAB

1 mg

10

11.00

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By |2022-07-20T16:44:52+00:00July 20, 2022|Uncategorized|Comments Off on Alprazolam

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