Drug Information


 




Amikacin

  













  

Pharmacokinetics

After IM injection Amikacin reaches a peak level in 60 to 90 mins. It
is bound to plasma protein and is excreted unchanged by glomerular
filtration via the kidneys. It is not affected by most body enzymes and
hence it is more effective than Gentamycin.

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Indication
& Dosage




IM/IV

SPETICAEMIA, SERIOUS RESP
TRACT INFECTIONS INCLUDING THOSE WITH PSEUDOMONAS IN PATIENTS WITH
CYSTIC FIBROSIS, INFECTIONS OF CNS, MENINGITIS INTRA-ABDOMINAL
INFECTIONS, UTI, BONE AND JOINT INFECTIONS, SKING BURNS AND
POSTOPERATIVE INFECTIONS:
Adults,
Children: 15mg/kg/day in 2 or 3 equally divided doses every  8 or
12 hrs. Maximum daily dose 500mg every 8hrs in life-threatening
infections. Total dose over 10 days not to exceed 15g. Premature babies
and neonates: A loading dose of 10mg/kg followed by 7.5mg/kg every
12hrs. Dosage in renal impairment: A rough guide for calculating the
dose in stable patients is to divide the normal dose by the patient’s
serum creatinine. This dose is given every 12hrs. More accurate methods
for dose calculation are also available.

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Action

Amikacin is active against a wide
range of Gram-negative and Gram-postive organisms including strains
resistant to other antimicrobials. Susceptible pathogens include
Pseudomonas, E coli, Proteus, Klebsiella, Serratia, Staphylococcus.
Amikacin is not active against anaerobes. This drug can be combined with
betalactam antibiotics including newer penicillins and third generation
cephalosporins. Amikacin exerts bactericidal action by inhibiting
protein synthesis.

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Interactions

There is
increased ototoxicity when used with ethacrynic acid. It potentiates
neuromuscular blocking agents.

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Adverse
Effect & Precaution




Hypersensitivity
reaction, nausea, vomiting, nephrotoxicity, ototoxicity, headache,
neuromuscular blockade.

Precautions are
to be taken if given in patients with nephrotoxicity, allergy, fever,
ototoxicity,and convulsions.

Pregnancy: Contraindicated

Breast Feeding: May be used

Man: Use with caution

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Brands
available in market







 
















































Amexel

   
INJ 100mg/2ml Vial 15.00  Nicholas-Piramal
INJ 250mg/2ml Vial 33.00 Nicholas-Piramal
INJ 500mg/2ml Vial 58.00 Nicholas-Piramal
Amibiotic


INJ 100mg/2ml Vial 15.48 Neon Labs
INJ 250mg/2ml Vial 34.56 Neon Labs
INJ 500mg/2ml Vial 59.88 Neon Labs
Amicin


INJ 100mg/2ml Vial 15.70 Biochem
INJ 250mg/2ml Vial 35.72 Biochem
INJ 500mg/2ml Vial 45.00 Biochem
Amineg


INJ 100mg/2ml 2 ml 15.14 Ind-Chemie
INJ 250mg/2ml 2 ml 33.12 Ind-Chemie
INJ 500mg/2ml 2 ml 58.67 Ind-Chemie
Amiron


INJ 100mg/2ml Vial 15.95 Kamron
INJ 250mg/2ml Vial 34.90 Kamron
INJ 500mg/2ml Vial 61.90 Kamron
Amisafe


INJ 100mg/2ml 2 ml 15.50 Indoco
INJ 250mg/2ml 2 ml 32.00 Indoco
INJ 500mg/2ml 2 ml 58.00 Indoco
Amitax


INJ 100mg Vial 15.14 Alkem
INJ 250mg Vial 33.12 Alkem
INJ 500mg Vial 58.67 Alkem
INJ 50mg Amp   9.50 Alkem
INJ 100mg Amp 14.75 Alkem
Amk


INJ 100mg/2ml Vial 14.95 Kee Pharma
INJ 250mg/2ml Vial 32.95 Kee Pharma
INJ 500mg/2ml Vial 57.95 Kee Pharma
Cinamica


INJ 100 mg 2ml Amp 12.37 Plethico
INJ 250 mg 2ml Amp 30.28 Plethico
INJ 500 mg 2ml Amp 52.48 Plethico
Cinamica-kit


INJ 100mg/2ml 1- pack 19.75 Plethico
INJ 250mg/2ml 1- pack 37.50 Plethico
Emica


INJ 100mg/2ml Vial 15.45 Lincoln
INJ 250mg/2ml Vial 29.90 Lincoln
INJ 500mg/2ml Vial 57.90 Lincoln
Erkacin


INJ 100 mg AMP 16.00 Brown & Burk
INJ 250 mg AMP 33.50 Brown & Burk
INJ 500 mg AMP 59.00 Brown & Burk
Glykacin

 
INJ 100mg/2ml Vial 15.50 Gland Pharma
INJ 250mg/2ml Vial 30.50 Gland Pharma
INJ 500mg/2ml Vial 58.00 Gland Pharma
Glykacin-PFS


INJ 100 mg 1 PFS 56.73 Gland Pharma
INJ 50 mg 1 PFS 51.19 Gland Pharma
Ivimicin


INJ 100 mg 2ml V 15.60 FDC
INJ 250 mg 2ml V 34.50 FDC



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Drug Information
 


Amikacin
  

  

Pharmacokinetics

After IM injection Amikacin reaches a peak level in 60 to 90 mins. It is bound to plasma protein and is excreted unchanged by glomerular filtration via the kidneys. It is not affected by most body enzymes and hence it is more effective than Gentamycin.

Top 

Indication & Dosage

IM/IV
SPETICAEMIA, SERIOUS RESP TRACT INFECTIONS INCLUDING THOSE WITH PSEUDOMONAS IN PATIENTS WITH CYSTIC FIBROSIS, INFECTIONS OF CNS, MENINGITIS INTRA-ABDOMINAL INFECTIONS, UTI, BONE AND JOINT INFECTIONS, SKING BURNS AND POSTOPERATIVE INFECTIONS:
Adults, Children: 15mg/kg/day in 2 or 3 equally divided doses every  8 or 12 hrs. Maximum daily dose 500mg every 8hrs in life-threatening infections. Total dose over 10 days not to exceed 15g. Premature babies and neonates: A loading dose of 10mg/kg followed by 7.5mg/kg every 12hrs. Dosage in renal impairment: A rough guide for calculating the dose in stable patients is to divide the normal dose by the patient’s serum creatinine. This dose is given every 12hrs. More accurate methods for dose calculation are also available.

Top

Action

Amikacin is active against a wide range of Gram-negative and Gram-postive organisms including strains resistant to other antimicrobials. Susceptible pathogens include Pseudomonas, E coli, Proteus, Klebsiella, Serratia, Staphylococcus. Amikacin is not active against anaerobes. This drug can be combined with betalactam antibiotics including newer penicillins and third generation cephalosporins. Amikacin exerts bactericidal action by inhibiting protein synthesis.

Top

Interactions

There is increased ototoxicity when used with ethacrynic acid. It potentiates neuromuscular blocking agents.

Top  

Adverse Effect & Precaution

Hypersensitivity reaction, nausea, vomiting, nephrotoxicity, ototoxicity, headache, neuromuscular blockade.

Precautions are to be taken if given in patients with nephrotoxicity, allergy, fever, ototoxicity,and convulsions.
Pregnancy: Contraindicated
Breast Feeding: May be used
Man: Use with caution

Top

 

Amexel

 

 

INJ

100mg/2ml

Vial

15.00 

Nicholas-Piramal

INJ

250mg/2ml

Vial

33.00

Nicholas-Piramal

INJ

500mg/2ml

Vial

58.00

Nicholas-Piramal

Amibiotic

INJ

100mg/2ml

Vial

15.48

Neon Labs

INJ

250mg/2ml

Vial

34.56

Neon Labs

INJ

500mg/2ml

Vial

59.88

Neon Labs

Amicin

INJ

100mg/2ml

Vial

15.70

Biochem

INJ

250mg/2ml

Vial

35.72

Biochem

INJ

500mg/2ml

Vial

45.00

Biochem

Amineg

INJ

100mg/2ml

2 ml

15.14

Ind-Chemie

INJ

250mg/2ml

2 ml

33.12

Ind-Chemie

INJ

500mg/2ml

2 ml

58.67

Ind-Chemie

Amiron

INJ

100mg/2ml

Vial

15.95

Kamron

INJ

250mg/2ml

Vial

34.90

Kamron

INJ

500mg/2ml

Vial

61.90

Kamron

Amisafe

INJ

100mg/2ml

2 ml

15.50

Indoco

INJ

250mg/2ml

2 ml

32.00

Indoco

INJ

500mg/2ml

2 ml

58.00

Indoco

Amitax

INJ

100mg

Vial

15.14

Alkem

INJ

250mg

Vial

33.12

Alkem

INJ

500mg

Vial

58.67

Alkem

INJ

50mg

Amp

  9.50

Alkem

INJ

100mg

Amp

14.75

Alkem

Amk

INJ

100mg/2ml

Vial

14.95

Kee Pharma

INJ

250mg/2ml

Vial

32.95

Kee Pharma

INJ

500mg/2ml

Vial

57.95

Kee Pharma

Cinamica

INJ

100 mg

2ml Amp

12.37

Plethico

INJ

250 mg

2ml Amp

30.28

Plethico

INJ

500 mg

2ml Amp

52.48

Plethico

Cinamica-kit

INJ

100mg/2ml

1- pack

19.75

Plethico

INJ

250mg/2ml

1- pack

37.50

Plethico

Emica

INJ

100mg/2ml

Vial

15.45

Lincoln

INJ

250mg/2ml

Vial

29.90

Lincoln

INJ

500mg/2ml

Vial

57.90

Lincoln

Erkacin

INJ

100 mg

AMP

16.00

Brown & Burk

INJ

250 mg

AMP

33.50

Brown & Burk

INJ

500 mg

AMP

59.00

Brown & Burk

Glykacin

 

INJ

100mg/2ml

Vial

15.50

Gland Pharma

INJ

250mg/2ml

Vial

30.50

Gland Pharma

INJ

500mg/2ml

Vial

58.00

Gland Pharma

Glykacin-PFS

INJ

100 mg

1 PFS

56.73

Gland Pharma

INJ

50 mg

1 PFS

51.19

Gland Pharma

Ivimicin

INJ

100 mg

2ml V

15.60

FDC

INJ

250 mg

2ml V

34.50

FDC

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By |2022-07-20T16:42:46+00:00July 20, 2022|Uncategorized|Comments Off on Amikacin

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