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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions
Adverse
Effect & Precautions |
Brands available in Market
Pharmacokinetics
It has a long
half life, hence a single dose is enough, as blood levels are maintained
due to low metabolism in the body
Indication and Dosage
Oral
LIFE-THREATENING
VENTRICULAR ARRHYTHMIAS-VENTRICULAR FIBRILLATION, HAEMODYNAMICALLY
UNSTABLE VENTRICULAR TACHYCARDIA:
Loading dose:
800-1600mg/day in divided doses for 1-3 week.
Transition dose: 800-1600mg/day in divided doses for 1 month.
Maintenance dose: 400mg/day
Lowest possible maintenance dose should be used to minimise side effects.
SUPRAVENTRICULAR TACHYCARDIAS, ARRHYTHAMIAS ASSOCIATED WITH ACCELERATE
CONDUCTION: 1st week: 200mg t.i.d ,2nd week:200mg b.i.d Maintenance: 200mg
daily.
IV
FOR THE ABOVE INDICATIONS: 5mg/kg over 20-120 min. via caval catheter,
with ECG monitoring. Max: 1.2g/day
Action
Amiodarone Exerts a
class lll (Vaughan Williams Classification) type of antiarrythimic action.
It prolongs the duration of the action potential of all cardiac
fibres as well as the refractory period. Sinus rate is reduced by 15-20%
PR-QT intervals are increased. Amiodarone can cause marked sinus
bradycardia or sinus arrest and heart block. In acute IV doses amiodarone
may exert a mild negative inotropic effect.
Interactions
It reduces the clearance of Anticoagulants, quinidine, Phenytoin,
Procainamide and their effects may be increased.
Precautions
Allergies: Allergic reactions may occur during the use of
amiodarone. Pregnancy : Amiodarone has been shown to potentiate
thyroid effects in babies whose mothers took amiodarone when
pregnant. In addition, there is concern that amiodarone could
cause bradycardia in the new born. Breast-feeding: Although
amiodarone passes into breast milk, it has not been shown to cause
problems in nursing babies. Older adults: Elderly patients may be
more likely to have thyroid effects with this drug. Also, unstable
gait, numbness, tingling, trembling, or weakness in hands or feet
are more likely to occur in the elderly.
Name
MRP
Manufacturers
Aldarone
INJ
50 mg/ml
3 ml
11.30
Alidac
Amiodar 100
TAB
100 mg
10
43.80
Micro Labs
Amiodar 200
TAB
100 mg
10
43.80
Micro Labs
Amidarone HCL -Chile
INJ
150 mg
3 ml Amp
53.00
Shree Ganesh
Cordarone
TAB
200 mg
10
87.50
Torrent
INJ-IV
50 mg/ml
3 ml
32.12
Torrent
Eurythmic
INJ
50 mg/ml
5×3 ml
175.00
Troikaa
TABS
100 mg
10×10
400.00
Troikaa
TABS
200 mg
10×10
700.00
Troikaa
