It has a long half life, hence a single dose is enough, as blood levels are maintained due to low metabolism in the body
Indication and Dosage
LIFE-THREATENING VENTRICULAR ARRHYTHMIAS-VENTRICULAR FIBRILLATION, HAEMODYNAMICALLY UNSTABLE VENTRICULAR TACHYCARDIA:
Loading dose: 800-1600mg/day in divided doses for 1-3 week.
Transition dose: 800-1600mg/day in divided doses for 1 month.
Maintenance dose: 400mg/day
Lowest possible maintenance dose should be used to minimise side effects.
SUPRAVENTRICULAR TACHYCARDIAS, ARRHYTHAMIAS ASSOCIATED WITH ACCELERATE CONDUCTION: 1st week: 200mg t.i.d ,2nd week:200mg b.i.d Maintenance: 200mg daily.
FOR THE ABOVE INDICATIONS: 5mg/kg over 20-120 min. via caval catheter, with ECG monitoring. Max: 1.2g/day
Amiodarone Exerts a class lll (Vaughan Williams Classification) type of antiarrythimic action. It prolongs the duration of the action potential of all cardiac fibres as well as the refractory period. Sinus rate is reduced by 15-20% PR-QT intervals are increased. Amiodarone can cause marked sinus bradycardia or sinus arrest and heart block. In acute IV doses amiodarone may exert a mild negative inotropic effect.
It reduces the clearance of Anticoagulants, quinidine, Phenytoin, Procainamide and their effects may be increased.
Allergies: Allergic reactions may occur during the use of amiodarone. Pregnancy : Amiodarone has been shown to potentiate thyroid effects in babies whose mothers took amiodarone when pregnant. In addition, there is concern that amiodarone could cause bradycardia in the new born. Breast-feeding: Although amiodarone passes into breast milk, it has not been shown to cause problems in nursing babies. Older adults: Elderly patients may be more likely to have thyroid effects with this drug. Also, unstable gait, numbness, tingling, trembling, or weakness in hands or feet are more likely to occur in the elderly.
Amidarone HCL -Chile
3 ml Amp