Drug Information

 





Amitriptyline

  












 

Pharmacokinetics

 

Amitriptyline, after oral
administration, is distributed widely and is metabolised ot
nortriptyline whic is active
.

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Indication
& Dosage

DEPRESSION:
Initially 25mg 3 times daily. This may be increased upto 150mg daily in
divided doses. Dose increments should be made in the late afternoon
and/or at bedtime. Elderly and adolescents: 10mg t.i.d may be sufficent.
Children: Below 12yrs amitriptyline is not recommended.

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Action

Amitriptyline
exerts its antidepressant action by blocking the neuronal reuptake of
noradrenaline and sertonin. Amitriptyline has some sedative action.
Endogenous depression responds to a greater extent than other types.
Amitriptyline has significant anticholinergic activity.

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Interactions

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Adverse
Effect & Precaution




Epigastrid distress,
sedation, drowsiness, orthostatic hypotension, palpitation, dry mouth,
urinary retention, blurred vision, confusion, lowering of seizure
threshold.



Precaution: Cardiac, hepatic or renal
disease. Not to drive or operate heavy machinery, hpethyroidism,
activation of latent schizophrenia may occur, suicidal tendency in
seriously depressed patients.

Pregnancy: Safety not established

Breast Feeding: Use with caution

Man: May be given in reduced dose

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Brands
available in market






 



































Amiline

TAB

10 mg

10

  2.45

Torrent

TAB

25 mg

10

  4.80

Torrent

TAB

75 mg

10

13.35

Torrent

Amitone

TAB

10 mg

10

  6.25

Intas

TAB

25 mg

10

10.25

Intas

TAB

75 mg

10

20.00

Intas

Eliwel

TAB

25 mg

10 

  8.30

Sun Pharma

TAB

75 mg

10

20.40

Sun Pharma

Kamitrin

TAB

10 mg

10

  4.63

Saga Labs

TAB

25 mg

10

  7.70

Saga Labs

Latilin

TAB

25 mg

10

  9.00

LA Pharma

TAB

50 mg

10

14.00

LA Pharma

TAB

75 mg

10

20.00

LA Pharma

Sarotena

TAB

10 mg

10

  8.00

CFL

TAB

25 mg

10

13.40

CFL

TAB

50 mg

!0

24.00

CFL

Tridep

TAB

10 mg

10

  4.10

Torrent

TAB

25 mg

10

  8.00

Torrent

TAB

75 mg

10

19.70

Torrent

Tryptomer

TAB

10 mg

10

  8.67  

Merind

TAB

25 mg

10

15.09

Merind

TAB

75 mg

10

35.77

Merind




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Drug Information
 


Amitriptyline
  

 
Pharmacokinetics
 
Amitriptyline, after oral administration, is distributed widely and is metabolised ot nortriptyline whic is active.

Top

Indication & Dosage

DEPRESSION: Initially 25mg 3 times daily. This may be increased upto 150mg daily in divided doses. Dose increments should be made in the late afternoon and/or at bedtime. Elderly and adolescents: 10mg t.i.d may be sufficent. Children: Below 12yrs amitriptyline is not recommended.

Top
 

Action

Amitriptyline exerts its antidepressant action by blocking the neuronal reuptake of noradrenaline and sertonin. Amitriptyline has some sedative action. Endogenous depression responds to a greater extent than other types. Amitriptyline has significant anticholinergic activity.

Top
 

Adverse Effect & Precaution

Epigastrid distress, sedation, drowsiness, orthostatic hypotension, palpitation, dry mouth, urinary retention, blurred vision, confusion, lowering of seizure threshold.

Precaution: Cardiac, hepatic or renal disease. Not to drive or operate heavy machinery, hpethyroidism, activation of latent schizophrenia may occur, suicidal tendency in seriously depressed patients.
Pregnancy: Safety not established
Breast Feeding: Use with caution
Man: May be given in reduced dose

Top
 

 

Amiline

TAB

10 mg

10

  2.45

Torrent

TAB

25 mg

10

  4.80

Torrent

TAB

75 mg

10

13.35

Torrent

Amitone

TAB

10 mg

10

  6.25

Intas

TAB

25 mg

10

10.25

Intas

TAB

75 mg

10

20.00

Intas

Eliwel

TAB

25 mg

10 

  8.30

Sun Pharma

TAB

75 mg

10

20.40

Sun Pharma

Kamitrin

TAB

10 mg

10

  4.63

Saga Labs

TAB

25 mg

10

  7.70

Saga Labs

Latilin

TAB

25 mg

10

  9.00

LA Pharma

TAB

50 mg

10

14.00

LA Pharma

TAB

75 mg

10

20.00

LA Pharma

Sarotena

TAB

10 mg

10

  8.00

CFL

TAB

25 mg

10

13.40

CFL

TAB

50 mg

!0

24.00

CFL

Tridep

TAB

10 mg

10

  4.10

Torrent

TAB

25 mg

10

  8.00

Torrent

TAB

75 mg

10

19.70

Torrent

Tryptomer

TAB

10 mg

10

  8.67  

Merind

TAB

25 mg

10

15.09

Merind

TAB

75 mg

10

35.77

Merind

Top
 

 

By |2022-07-20T16:44:52+00:00July 20, 2022|Uncategorized|Comments Off on Amitriptyline

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