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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions
Precautions |
Brands available in Market
Pharmacokinetics
Amitriptyline, after oral
administration, is distributed widely and is metabolised ot
nortriptyline whic is active.
DEPRESSION: Initially 25mg 3 times daily. This may be increased upto 150mg daily in divided doses. Dose increments should be made in the late afternoon and/or at bedtime. Elderly and adolescents: 10mg t.i.d may be sufficent. Children: Below 12yrs amitriptyline is not recommended.
Amitriptyline exerts its antidepressant action by blocking the neuronal reuptake of noradrenaline and sertonin. Amitriptyline has some sedative action. Endogenous depression responds to a greater extent than other types. Amitriptyline has significant anticholinergic activity.
Adverse
Effect & Precaution
Epigastrid distress,
sedation, drowsiness, orthostatic hypotension, palpitation, dry mouth,
urinary retention, blurred vision, confusion, lowering of seizure
threshold.
Precaution: Cardiac, hepatic or renal
disease. Not to drive or operate heavy machinery, hpethyroidism,
activation of latent schizophrenia may occur, suicidal tendency in
seriously depressed patients.
Pregnancy: Safety not established
Breast Feeding: Use with caution
Man: May be given in reduced dose
Amiline
TAB
10 mg
10
2.45
Torrent
TAB
25 mg
10
4.80
Torrent
TAB
75 mg
10
13.35
Torrent
Amitone
TAB
10 mg
10
6.25
Intas
TAB
25 mg
10
10.25
Intas
TAB
75 mg
10
20.00
Intas
Eliwel
TAB
25 mg
10
8.30
Sun Pharma
TAB
75 mg
10
20.40
Sun Pharma
Kamitrin
TAB
10 mg
10
4.63
Saga Labs
TAB
25 mg
10
7.70
Saga Labs
Latilin
TAB
25 mg
10
9.00
LA Pharma
TAB
50 mg
10
14.00
LA Pharma
TAB
75 mg
10
20.00
LA Pharma
Sarotena
TAB
10 mg
10
8.00
CFL
TAB
25 mg
10
13.40
CFL
TAB
50 mg
!0
24.00
CFL
Tridep
TAB
10 mg
10
4.10
Torrent
TAB
25 mg
10
8.00
Torrent
TAB
75 mg
10
19.70
Torrent
Tryptomer
TAB
10 mg
10
8.67
Merind
TAB
25 mg
10
15.09
Merind
TAB
75 mg
10
35.77
Merind
