Drug Information


 





Amlodipine

  












Amlodipine

Pharmacokinetics

It has complete but slow oral absorption .Peak after
6-9hours, so the early vasodilator side effects such as palpitation,
flushing, headache and postural dizzines are avoided. Because of less
extensive and less variable first pass metabolism, its oral
bioavailability is higher and more consistent. .Diurnal fluctuation in
blood level is small and protection extending over the next morning is
afforded.

Top

  

Indication &
Dosage



Oral

HYPERTENSION: Start with 5mg once daily and increase over 7-14 days
up to maz of 10mg once daily. Elderly: Patients Can be started on
2.5mg/day and the dose built up as required.

CHRONIC STABLE ANGINA: 5-10mg once daily.

VASOSPASTIC ANGINA:5-10mg once daily.

Amlodipine can be given in combination with betablockers, ACE inhibitors
thiazides and nitrates.

Top

 

Action

Amlodipine inhibits the movement of calcium ion (ca2+) across the
cell membrane into vascular smooth muscles and myocytes. Action is
greater in the arterial resistant vessels causing peripheral
vasodilatation and reduction in afterload. Action on the myocardium is
considerably less, Clinically, blood pressure is reduced without significant
increases in heart rate. In anginal patients reduction of afterload
reduces myocardial oxygen requirement. Severity and frequency  of
anignal attacks are reduced while exercise tolerance is increased.

Top

 

Interaction




Amlodipine potentiates the effects of thiazide diuretics and ACE
inhibitors. Avoid combinations with beta blockers in patients with
impaired left ventricular function
.

Top

 

Adverse
Effect & Precaution




Headache, dizziness, ankle oedema, flushing.




Precaution has to be taken in impaired liver & renal function,
congestive heart failure, elderly, children and lactating mothers.

Pregancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be used in lowered dose.

Top

 

Brands available in
Market




 

























AM-5


TAB 5 mg 10 10.00 Orchid
Amanat


TAB 5 mg 10   6.80 Octan
TAB 10 mg 10 12.50 Octan
Amcard


TAB 2.5 mg 10   6.10 Systopic
TAB 5 mg 10   9.70 Systopic
TAB 10 mg 10 17.80 Systopic
Amdepin


TAB 5 mg 10 20.90 Cadila Pharma
TAB 10 mg 10 41.50 Cadila Pharma
Amlocor


TAB 2.5 mg 10 12.00 Torrent
TAB 5 mg 10 19.90 Torrent
TAB 10 mg 10 39.90 Torrent
Amlodac


TAB 5 mg 10   5.00 Alidac
TAB 2.5 mg 10   3.00 Alidac
TAB 10 mg 10 10.00 Alidac
Amlogard


TAB 5 mg 10 48.13 Pfizer
TAB 10 mg 10 72.13 Pfizer
Amlogen


TAB 5 mg 10 12.00 Alkem
TAB 10 mg 10 21.00 Alkem
Amlong


TAB 10 mg 10  44.00 Micro Labs
TAB 2.5 mg 10 16.00 Micro Labs
TAB 5 mg 10 28.00 Micro Labs



Top

 







 

   


Drug Information
 


Amlodipine
  

Amlodipine

Pharmacokinetics

It has complete but slow oral absorption .Peak after 6-9hours, so the early vasodilator side effects such as palpitation, flushing, headache and postural dizzines are avoided. Because of less extensive and less variable first pass metabolism, its oral bioavailability is higher and more consistent. .Diurnal fluctuation in blood level is small and protection extending over the next morning is afforded.

Top
  

Indication & Dosage
Oral
HYPERTENSION: Start with 5mg once daily and increase over 7-14 days up to maz of 10mg once daily. Elderly: Patients Can be started on 2.5mg/day and the dose built up as required.
CHRONIC STABLE ANGINA: 5-10mg once daily.
VASOSPASTIC ANGINA:5-10mg once daily.
Amlodipine can be given in combination with betablockers, ACE inhibitors thiazides and nitrates.

Top
 

Action
Amlodipine inhibits the movement of calcium ion (ca2+) across the cell membrane into vascular smooth muscles and myocytes. Action is greater in the arterial resistant vessels causing peripheral vasodilatation and reduction in afterload. Action on the myocardium is considerably less, Clinically, blood pressure is reduced without significant increases in heart rate. In anginal patients reduction of afterload reduces myocardial oxygen requirement. Severity and frequency  of anignal attacks are reduced while exercise tolerance is increased.

Top
 

Interaction

Amlodipine potentiates the effects of thiazide diuretics and ACE inhibitors. Avoid combinations with beta blockers in patients with impaired left ventricular function.

Top
 

Adverse Effect & Precaution

Headache, dizziness, ankle oedema, flushing.


Precaution has to be taken in impaired liver & renal function, congestive heart failure, elderly, children and lactating mothers.
Pregancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be used in lowered dose.

Top
 

 

AM-5

TAB

5 mg

10

10.00

Orchid

Amanat

TAB

5 mg

10

  6.80

Octan

TAB

10 mg

10

12.50

Octan

Amcard

TAB

2.5 mg

10

  6.10

Systopic

TAB

5 mg

10

  9.70

Systopic

TAB

10 mg

10

17.80

Systopic

Amdepin

TAB

5 mg

10

20.90

Cadila Pharma

TAB

10 mg

10

41.50

Cadila Pharma

Amlocor

TAB

2.5 mg

10

12.00

Torrent

TAB

5 mg

10

19.90

Torrent

TAB

10 mg

10

39.90

Torrent

Amlodac

TAB

5 mg

10

  5.00

Alidac

TAB

2.5 mg

10

  3.00

Alidac

TAB

10 mg

10

10.00

Alidac

Amlogard

TAB

5 mg

10

48.13

Pfizer

TAB

10 mg

10

72.13

Pfizer

Amlogen

TAB

5 mg

10

12.00

Alkem

TAB

10 mg

10

21.00

Alkem

Amlong

TAB

10 mg

10 

44.00

Micro Labs

TAB

2.5 mg

10

16.00

Micro Labs

TAB

5 mg

10

28.00

Micro Labs

Top
 

 

By |2022-07-20T16:44:57+00:00July 20, 2022|Uncategorized|Comments Off on Amlodipine

About the Author: