Drug Information 


 




Amodiaquine

  













 

Pharmacokinetics



It is readily absorbed from
the GI tract and is rapidly converted in the liver to the active
metabolite desethylamodiaquine.


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Indication & Dosage

Oral


TREATMENT OF MALRIAL ATTACK:
In partially immune patients: A Single dose
600mg. In non-immune subjects: 600mg once daily for 3 consecutive days.
Children under 15yrs: Partly immune-10mg/kg single dose. Non
immune-10mg/kg once on firs day followed by half of this dose daily for
the next 2 days.


MALSRIA PROPHYLAXIS:
Adult: 400mg once a week. Children: 7mg/kg once a
week. Children: 7mg/kg once a week continued for 4-6 weeks after leaving
endemic area. Amodiaquine though effective for prophylazis is no longer
used in many countries due to incident of agranulocytosis
.


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Action

 

Amodiaquine is an antimalarial with schizonticidal activity.
It is effective against the erythrocytic stages of all 4 species of
plasmodium except mature gametocytes of Plasmodium falciparum.
Amodiaquine accumulates in the lysosomes and brings about loss of
function. The parasite isunable to digest haemoglobin on whichit depends
ofr its energy.


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Interactions



Antifolic drugs (e.g.
Methotrexate, Sulphonamides TMP-SMZ): Do not use receiving sulfadoxine/pyrimethamine.


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Adverse Effect & Precaution

 

Nausea, vomiting, skin rash,
pruritus, erythemamultiforme.



Precaution: G6PD deficiency.

Pregnancy: Contraindicated

Breast Feeding: Contraindicated


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Brand availble in Market







 







Basoquin
SUSP 150mg/ml 30 ml   3.26 Parke-Davis
Camoquin
TAB 200 mg 10   3.41 Parde-Davis



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Drug Information 
 


Amodiaquine
  

 
Pharmacokinetics

It is readily absorbed from the GI tract and is rapidly converted in the liver to the active metabolite desethylamodiaquine.

Top
   

Indication & Dosage

Oral
TREATMENT OF MALRIAL ATTACK: In partially immune patients: A Single dose 600mg. In non-immune subjects: 600mg once daily for 3 consecutive days. Children under 15yrs: Partly immune-10mg/kg single dose. Non immune-10mg/kg once on firs day followed by half of this dose daily for the next 2 days.
MALSRIA PROPHYLAXIS: Adult: 400mg once a week. Children: 7mg/kg once a week. Children: 7mg/kg once a week continued for 4-6 weeks after leaving endemic area. Amodiaquine though effective for prophylazis is no longer used in many countries due to incident of agranulocytosis
.

Top
   

Action
 
Amodiaquine is an antimalarial with schizonticidal activity. It is effective against the erythrocytic stages of all 4 species of plasmodium except mature gametocytes of Plasmodium falciparum. Amodiaquine accumulates in the lysosomes and brings about loss of function. The parasite isunable to digest haemoglobin on whichit depends ofr its energy.

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Interactions

Antifolic drugs (e.g. Methotrexate, Sulphonamides TMP-SMZ): Do not use receiving sulfadoxine/pyrimethamine.

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Adverse Effect & Precaution
 
Nausea, vomiting, skin rash, pruritus, erythemamultiforme.

Precaution: G6PD deficiency.
Pregnancy: Contraindicated
Breast Feeding: Contraindicated

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Basoquin

SUSP

150mg/ml

30 ml

  3.26

Parke-Davis

Camoquin

TAB

200 mg

10

  3.41

Parde-Davis

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By |2022-07-20T16:44:53+00:00July 20, 2022|Uncategorized|Comments Off on Amodiaquine

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