Drug Information





Amoxapine

  















 

Pharmacokinetics

 

It is converted to active metabolite

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Indication and Dosage




Obsessive compulsive neurosis, endogenous depression, behavioural
disorders.

Dosage: Adults: Initially 100-150mg daily.
Increase, if requred, to 300mg daily in divided doses. Usual Maint. dose
150-250mg daily.

Elderly: Intially 25mg twice daily increasing under supervision after 5-7
days to 50mg thrice daily. Max. 150mg per day

Children: Not recommended.

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Action

In addition to its effect on monoamines, this drug also blocks dopamine
receptors. Significant anticholinergic effects, moderate sedation, and
slight orthostatic hypotensive effect. Metabolized to the active
metabolites 7-hydroxy- and 8-hydroxyamoxapine. Peak blood levels: 90
min. Effective plasma levels: 200-500 ng/mL. Time to reach
steady state: 2-7 days. t1/2: 8 hr; t1/2 of
major metabolite: 30 hr. Excreted in urine.

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Interaction

 


Anticholinergics: Enhanced effect of anticholinergics may occur.

Barbiturates: Serum level of Amoxapine decreased; additive respiratory
depressant effect.

Clonidine: Hypertensive crisis.

Dicoumarol: Increase in antiocagulation effects.

Disulfiram: Acute organic brain syndrome.

Fluoxetine & Haloperidol: Potentiate action of amoxapine.

Levodopa: Its bioavialabilty is reduced, hypertensive episodes.

MAOIs, Furazolidone: Seizures sweating, coma, hyperexcitability,
hyperthermia, tachycardia, mydriasis, confusion. DIC. (Disseminatd
intravascular Coagulation) and death.

Oral Contraceptives Phenothiazines: Increase plasma levelsof amoxapine.

Smoking: Increases metabolic bio-transformation.

Alchohol: Sedative effect of alcohol potentiated.

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Adverse Effect
& Precautions
 

 

Jaundice, sedation, drowsiness, seizures, cardiac arrhythmias, blood
dyscrasias.



Precaution: Diabetes, myocardial infarction,
epilepsy, mania.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated

Man: May be given in reduced dose.

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Brands available in Market

 
 





DEMOLOX

Wyeth
Lederle
TAB 10 50mg 31.73


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 Drug Information


Amoxapine
  

 
Pharmacokinetics
 
It is converted to active metabolite

Top
  

Indication and Dosage

Obsessive compulsive neurosis, endogenous depression, behavioural disorders.
Dosage: Adults: Initially 100-150mg daily. Increase, if requred, to 300mg daily in divided doses. Usual Maint. dose 150-250mg daily.
Elderly: Intially 25mg twice daily increasing under supervision after 5-7 days to 50mg thrice daily. Max. 150mg per day
Children: Not recommended.

Top
  

Action

In addition to its effect on monoamines, this drug also blocks dopamine receptors. Significant anticholinergic effects, moderate sedation, and slight orthostatic hypotensive effect. Metabolized to the active metabolites 7-hydroxy- and 8-hydroxyamoxapine. Peak blood levels: 90 min. Effective plasma levels: 200-500 ng/mL. Time to reach steady state: 2-7 days. t1/2: 8 hr; t1/2 of major metabolite: 30 hr. Excreted in urine.

Top
  

Interaction
 

Anticholinergics: Enhanced effect of anticholinergics may occur.
Barbiturates: Serum level of Amoxapine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in antiocagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of amoxapine.
Levodopa: Its bioavialabilty is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures sweating, coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion. DIC. (Disseminatd intravascular Coagulation) and death.
Oral Contraceptives Phenothiazines: Increase plasma levelsof amoxapine.
Smoking: Increases metabolic bio-transformation.
Alchohol: Sedative effect of alcohol potentiated.

Top
 

Adverse Effect & Precautions 
 
Jaundice, sedation, drowsiness, seizures, cardiac arrhythmias, blood dyscrasias.

Precaution: Diabetes, myocardial infarction, epilepsy, mania.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated
Man: May be given in reduced dose.

Top
 

 

DEMOLOX

Wyeth Lederle

TAB

10

50mg

31.73

Top
 

 

By |2022-07-20T16:44:51+00:00July 20, 2022|Uncategorized|Comments Off on Amoxapine

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