Drug Information


 





Aspirin

  















  

Pharmacokinetics


 

It is absorbed mainly from the stomach and upper part of the small
intestine, 60% undergoes hepatic metabolism, it has a half life of 2-8
hrs.

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Indication & Dosage

 



Oral



MILD TO MODERATE PAIN ACUTE AND CHORNIC INFLAMMATORY CONDITIONS SUCH AS
(RA), OSTEOPARTHRITIS (OA), SPONDYLOSIS, ANTIPYRETIC:
300-900mg every 4-6
hours upto max of 4g/day.


JUVENILE RHEUMATOID ARTHRITIS:
The only condition for which aspirin cn be
used in children, 80-100mg/kg/day in divided doses.

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Action 

 


Aspirin is an analgesic, anti-inflammatory and antipyretic. This action
depends on the inhibition of the enzyme cyclo-oxygenase in the pathway of
prostaglandin synthesis. Reduction of PG reduces inflammation, pain and
fever. Fever is also reduced by an effect on the hypothalamus. Aspirin
inhibits the formation of thromboxane A2 in the platelets. This inhibits
platelet aggregation and coagulation. This action lasts until the enzyme
cyclo-oxygenase is regenerated in the platelets.

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Interaction

 


Interaction with the
following drugs are common:Acetaminophen, Diclofenac, Diflunisal, Etodolac,
Fenoprofen, Floctafenine, Flurbiprofen, oral Ibuprofen .

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Precautions

 

Buffered aspirin with choline and magnesium salicylates, or magnesium
salicylate can reduce the effectiveness of certain drugs, especially
antibiotics. Aspirin suppositories may cause irritation of the rectum.

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Brands available in
Market


 




















COLSPRIN

Reckitt & Colman
TAB 325mg 10 2.16
TAB 650mg 10 3.22
COTASPRIN

Natco
TAB 325mg 10 2.52
ECOSPRIN

USV
EC-TAB 325mg 10 10.50
MAZORAL

CFL
TAB 75mg 14 2.45
OPTAZ-75

Plethico
E-C TABS 75mg 14 8.47
OTASPIRIN

Natco
TAB 500mg 30 14.99
ZOSPRIN

Medley
EC TAB 75mg 10 6.50
EC TAB 150mg 10 7.90




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Drug Information
 


Aspirin
  

  
Pharmacokinetics

 
It is absorbed mainly from the stomach and upper part of the small intestine, 60% undergoes hepatic metabolism, it has a half life of 2-8 hrs.

Top
  

Indication & Dosage
 

Oral
MILD TO MODERATE PAIN ACUTE AND CHORNIC INFLAMMATORY CONDITIONS SUCH AS (RA), OSTEOPARTHRITIS (OA), SPONDYLOSIS, ANTIPYRETIC: 300-900mg every 4-6 hours upto max of 4g/day.
JUVENILE RHEUMATOID ARTHRITIS: The only condition for which aspirin cn be used in children, 80-100mg/kg/day in divided doses.

Top
  

Action 
 

Aspirin is an analgesic, anti-inflammatory and antipyretic. This action depends on the inhibition of the enzyme cyclo-oxygenase in the pathway of prostaglandin synthesis. Reduction of PG reduces inflammation, pain and fever. Fever is also reduced by an effect on the hypothalamus. Aspirin inhibits the formation of thromboxane A2 in the platelets. This inhibits platelet aggregation and coagulation. This action lasts until the enzyme cyclo-oxygenase is regenerated in the platelets.

Top
  

Interaction
 

Interaction with the following drugs are common:Acetaminophen, Diclofenac, Diflunisal, Etodolac, Fenoprofen, Floctafenine, Flurbiprofen, oral Ibuprofen .

Top
  

Precautions
 
Buffered aspirin with choline and magnesium salicylates, or magnesium salicylate can reduce the effectiveness of certain drugs, especially antibiotics. Aspirin suppositories may cause irritation of the rectum.

Top
 

COLSPRIN

Reckitt & Colman

TAB

325mg

10

2.16

TAB

650mg

10

3.22

COTASPRIN

Natco

TAB

325mg

10

2.52

ECOSPRIN

USV

EC-TAB

325mg

10

10.50

MAZORAL

CFL

TAB

75mg

14

2.45

OPTAZ-75

Plethico

E-C TABS

75mg

14

8.47

OTASPIRIN

Natco

TAB

500mg

30

14.99

ZOSPRIN

Medley

EC TAB

75mg

10

6.50

EC TAB

150mg

10

7.90

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By |2022-07-20T16:42:45+00:00July 20, 2022|Uncategorized|Comments Off on Aspirin

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