Drug Information






Atenolol

  











  

Pharmacokinetics


 

Atenolol is well absorbed after oral administration,
it undergoes extensive hepatic (first pass) metabolism. Its
bioavailability is 40%. It has a large volume of distribution and is
less completely metabolised before its excretion via urine. Because of
hepatic metabolism, a part of the oral dose may not reach the peripheral
circulation, so the plasma half-life doesn’t correlate with the duration
of the therapeutic effects, which is relatively long lasting. This is
because the plasma 1/2 life decreases exponentially, following first
order kinetics while the effect decreases linearly following zero order
kinetics.

 Top

  



Indication and Dosage


 


Oral

HYPERTENSION-ESSENTIAL:
25-50mg once daily may be increased to 100mg once daily. Elderly: Dosage
may depend on renal function. Children: Atenolol is not recommended

ANGINA: 25-50mg once daily may be increased to 100mg once daily. Elderly:
Dosage may depend on renal function. Children: Atenolol is not recommended

CARDIAC ARRHYTHMIAS: 50-100mg/day. May be regulated upwards depending on
response.

LEFT VENTRICULAR HYPERTROPHY THYROTOXICOSIS, WITHDRAWAL SYNDROMES:
50-100mg once daily.

 Top

 

Action

Atenolol is a
cardioselective beta blocker. It does not have any membrane-stablising or
partial agonist activity. Its cardioselectivity is dose-related. Atenolol
reduces resting and exercise-induced heart rate as also myocardial
contractility. Resting cardiac output but not exercise-induced output, is
increased to some extent. Peripherally betablockade may result in
vasoconstriction due to unopposed alpha activity. Coronary flow may be
reduced but this may not be significant except in vasospastic angina.
Atenolol reduces systolic and diastolic blood pressures. The reduction in
BP  and HR results in reduced myocardial work and oxygen requirment.
Anginal attacks are reduced in intensity and frequency, and exercise
tolerance is improved.

Top

 



Interactions



Atenolol sometimes increases the risk of serious allergic reaction
to these drugs: Aminophylline, Caffeine Oxtriphylline or
Theophylline (the effects of both these drugs and beta-blockers
may be blocked; in addition, theophylline levels in the body may
be increased, especially in patients who smoke). Oral
Antidiabetics or Insulin : There is an increased risk of
hyperglycemia  beta-blockers may mask certain symptoms of
hypoglycemia such as increases in pulse rate and hypertension, and
may prolong the hypoglycemia. Calcium channel blockers (bepridil,
diltiazem, felodipine, flunarizine, isradipine, nicardipine,
nifedipine, nimodipine, verapamil or Clonidine or Guanabenz) :
Risk of hypertension may be increased, cardiac arrhythmias may
occur when beta-blockers are used with calcium channel blockers.
Cocaine : cocaine may block the effects of beta-blockers; in
addition, there is an increased risk of hypertension, tachycardia,
and possibly cardiac arrhythmias if cocaine is used while taking a
beta-blocker. With Monoamine oxidase (MAO) inhibitors : taking
beta-blockers within 2 weeks of taking monoamine oxidase (MAO)
inhibitors may cause severe hypertension.

Top

 



Adverse
Effect & Precautions




Bradycardia, nausea,
vomiting, epigastric disness, skin rash, leg pain, cold
extremiteis because of periphral arterial insufficiency




 
 



Allergies : Allergic reaction to the beta-blocker.
Pregnancy : Use of beta-blockers during pregnancy has been
associated with hypoglycaemia, dyspnoea, bradycardia, and
hypotension in the newborn infant. Breast-feeding : Atenolol may
pass into breast milk. Problems such as bradycardia, hypotension,
and dyspnoea have been reported in nursing babies. Older adults :
Some side effects are more likely to occur in the elderly, who are
usually more sensitive to the effects of beta-blockers. Also,
beta-blockers may reduce tolerance to cold temperatures in elderly
patients.

Pregnancy: Use with caution.

Breast Feeding: Use with caution

Man: May be given in reduced dose.

Top

 



Brands available in market :













































































































Name

  

 

MRP

Manufacturers

ALOTEN

 

  

  

  

TAB

50mg 

10

16.80

Core

TAB

100mg

10

20.00

Core

ALTOL

  

  

  

  

TAB

50mg

14

16.80

Indoco

TAB

100mg

10

13.00

Indoco

ANGITOL

TAB

25mg

15 x14

174.30

Ind-Swift

TAB

50mg

15 x 14

270.90

Ind-Swift

TAB

100mg

15 x 14

444.00

Ind-Swift

ANTIPRESS

 

 

 

 

TAB

50mg

10

13.00

Saga Labs

TAB

100mg

10

20.50

Saga Labs

ATCARDIL

  

  

  

 

TAB

50mg

14

18.36

Sun Pharma

TAB

100mg

14

35.18

Sun Pharma

ATECARD

   

     

  

  

TAB

25mg

14

12.00

Dabur

TAB

50mg

14

23.30

Dabur

TAB

100mg

14

35.00

Dabur

ATECOR

   

    

     

   

TAB

50mg

10

11.32

Win-Medicare

TAB

100mg

10

19.38

Win-Medicare

ATELOL

 

 

  

  

TAB

25mg

14

10.50

Themis Pharma

TAB

50mg

14

16.43

Themis Pharma

TAB

100mg

14

29.21

Themis Pharma

ATEN

 

 

 

 

TAB

25mg

14

11.75

Kopran

TAB

50mg

14

18.69

Kopran

TAB

75mg

14

26.94

Kopran

TAB

100mg

14

33.63

Kopran

ATENEX

  

 

   

 

TAB

25mg

14

12.60

Recon

TAB

50mg

14

19.80

Recon

TAB

100mg

14

33.00

Recon

ATENOVA

TAB

25mg

14

11.75

Lupin

TAB

50mg

14

21.00

Lupin

TAB

100mg

14

39.54

Lupin

ATORMIN

   

 

 

 

TAB

50mg

14

18.60

PCI

TAB

50mg

30

33.09

PCI

TAB

100mg

14

33.60

PCI

TAB

100mg

30

56.91

PCI

ATPARK

 

 

 

 

TAB

25mg

10

12.91

Parke Davis

TAB

50mg

10

19.90

Parke Davis

TAB

100mg

10

27.64

Parke Davis

BETA

TAB

50mg

14

19.00

Stadmed

TAB

100mg

14

34.50

Stadmed

BETACARD

   

   

   

 

TAB

25mg

14

14.90

Torrent

TAB

50mg

14

19.90

Torrent

TAB

100mg

14

36.90

Torrent

BETANOL

   

  

   

  

TAB

50mg

14

17.50

Unisearch

BETEN

  

  

  

  

TAB

50mg

10 x14

170.00

Sigma

TAB

100mg

14×10

317.80

Sigma

BIDUTEN

 

 

 

 

TAB

50mg

10

16.52

Croydon

BP-NOL

TAB

25mg

10

5.40

Elder

TAB

50mg

10

8.70

Elder

TAB

100mg

10

14.00

Elder

CATENOL

TAB

25mg

14

10.65

Alidac

TAB

50mg

14

20.75

Alidac

TAB

100mg

14

37.60

Alidac

EUCARD

  

 

  

 

TAB

50mg

14

21.00

Malladi Drugs

HIPRES

TAB

25mg

14

11.30

Cipla

TAB

50mg

14

18.65

Cipla

TAB

100mg

14

37.60

Cipla

LAKTEN-50

TAB

50mg

14

21.00

Shalaks

LONOL

  

 

 

  

TAB

25mg

14

12.82

Khandelwal

TAB

50mg

14

20.18

Khandelwal

TAB

100mg

10

16.45

Khandelwal

NORMOLOL

TAB

50mg

10

17.30

Pace(sol)

TAB

100mg

10

23.69

Pace(sol)

PERTENOL

TAB

50mg

14×10

135.00

Karnataka Antibiotics

TAB

100mg

14×10

245.00

Karnataka Antibiotics

TELOL

 

 

 

 

TAB

50mg

10

10.42

Max

TAB

100mg

10

18.03

Max

TENASE

  

   

  

 

TAB

50mg

10

11.90

Jenburkt

TENOLOL

TAB

25mg

14

13.00

IPCA

TAB

50mg

14

20.90

IPCA

TAB

100mg

14

35.90

IPCA

INJ

5mg

10ml

0.00

IPCA

TENSICARD

 

  

  

 

TAB

25mg

14×10

130.00

Troikaa

TAB

50mg

14×10

200.00

Troikaa

TENSIMIN

  

  

  

         

TAB

50mg

14

19.22

Unique

TAB

100mg

14

31.20

Unique



      Top

 






 

   


 Drug Information


Atenolol
  

  
Pharmacokinetics

 
Atenolol is well absorbed after oral administration, it undergoes extensive hepatic (first pass) metabolism. Its bioavailability is 40%. It has a large volume of distribution and is less completely metabolised before its excretion via urine. Because of hepatic metabolism, a part of the oral dose may not reach the peripheral circulation, so the plasma half-life doesn’t correlate with the duration of the therapeutic effects, which is relatively long lasting. This is because the plasma 1/2 life decreases exponentially, following first order kinetics while the effect decreases linearly following zero order kinetics.

 Top
  

Indication and Dosage
 

Oral
HYPERTENSION-ESSENTIAL: 25-50mg once daily may be increased to 100mg once daily. Elderly: Dosage may depend on renal function. Children: Atenolol is not recommended
ANGINA: 25-50mg once daily may be increased to 100mg once daily. Elderly: Dosage may depend on renal function. Children: Atenolol is not recommended
CARDIAC ARRHYTHMIAS: 50-100mg/day. May be regulated upwards depending on response.
LEFT VENTRICULAR HYPERTROPHY THYROTOXICOSIS, WITHDRAWAL SYNDROMES: 50-100mg once daily.

 Top
 

Action
Atenolol is a cardioselective beta blocker. It does not have any membrane-stablising or partial agonist activity. Its cardioselectivity is dose-related. Atenolol reduces resting and exercise-induced heart rate as also myocardial contractility. Resting cardiac output but not exercise-induced output, is increased to some extent. Peripherally betablockade may result in vasoconstriction due to unopposed alpha activity. Coronary flow may be reduced but this may not be significant except in vasospastic angina. Atenolol reduces systolic and diastolic blood pressures. The reduction in BP  and HR results in reduced myocardial work and oxygen requirment. Anginal attacks are reduced in intensity and frequency, and exercise tolerance is improved.

Top
 

Interactions

Atenolol sometimes increases the risk of serious allergic reaction to these drugs: Aminophylline, Caffeine Oxtriphylline or Theophylline (the effects of both these drugs and beta-blockers may be blocked; in addition, theophylline levels in the body may be increased, especially in patients who smoke). Oral Antidiabetics or Insulin : There is an increased risk of hyperglycemia  beta-blockers may mask certain symptoms of hypoglycemia such as increases in pulse rate and hypertension, and may prolong the hypoglycemia. Calcium channel blockers (bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, verapamil or Clonidine or Guanabenz) : Risk of hypertension may be increased, cardiac arrhythmias may occur when beta-blockers are used with calcium channel blockers. Cocaine : cocaine may block the effects of beta-blockers; in addition, there is an increased risk of hypertension, tachycardia, and possibly cardiac arrhythmias if cocaine is used while taking a beta-blocker. With Monoamine oxidase (MAO) inhibitors : taking beta-blockers within 2 weeks of taking monoamine oxidase (MAO) inhibitors may cause severe hypertension.

Top
 

Adverse Effect & Precautions

Bradycardia, nausea, vomiting, epigastric disness, skin rash, leg pain, cold extremiteis because of periphral arterial insufficiency
   
Allergies : Allergic reaction to the beta-blocker. Pregnancy : Use of beta-blockers during pregnancy has been associated with hypoglycaemia, dyspnoea, bradycardia, and hypotension in the newborn infant. Breast-feeding : Atenolol may pass into breast milk. Problems such as bradycardia, hypotension, and dyspnoea have been reported in nursing babies. Older adults : Some side effects are more likely to occur in the elderly, who are usually more sensitive to the effects of beta-blockers. Also, beta-blockers may reduce tolerance to cold temperatures in elderly patients.
Pregnancy: Use with caution.
Breast Feeding: Use with caution
Man: May be given in reduced dose.

Top
 

Brands available in market :

Name

  

 

MRP

Manufacturers

ALOTEN

 

  

  

  

TAB

50mg 

10

16.80

Core

TAB

100mg

10

20.00

Core

ALTOL

  

  

  

  

TAB

50mg

14

16.80

Indoco

TAB

100mg

10

13.00

Indoco

ANGITOL

TAB

25mg

15 x14

174.30

Ind-Swift

TAB

50mg

15 x 14

270.90

Ind-Swift

TAB

100mg

15 x 14

444.00

Ind-Swift

ANTIPRESS

 

 

 

 

TAB

50mg

10

13.00

Saga Labs

TAB

100mg

10

20.50

Saga Labs

ATCARDIL

  

  

  

 

TAB

50mg

14

18.36

Sun Pharma

TAB

100mg

14

35.18

Sun Pharma

ATECARD

   

     

  

  

TAB

25mg

14

12.00

Dabur

TAB

50mg

14

23.30

Dabur

TAB

100mg

14

35.00

Dabur

ATECOR

   

    

     

   

TAB

50mg

10

11.32

Win-Medicare

TAB

100mg

10

19.38

Win-Medicare

ATELOL

 

 

  

  

TAB

25mg

14

10.50

Themis Pharma

TAB

50mg

14

16.43

Themis Pharma

TAB

100mg

14

29.21

Themis Pharma

ATEN

 

 

 

 

TAB

25mg

14

11.75

Kopran

TAB

50mg

14

18.69

Kopran

TAB

75mg

14

26.94

Kopran

TAB

100mg

14

33.63

Kopran

ATENEX

  

 

   

 

TAB

25mg

14

12.60

Recon

TAB

50mg

14

19.80

Recon

TAB

100mg

14

33.00

Recon

ATENOVA

TAB

25mg

14

11.75

Lupin

TAB

50mg

14

21.00

Lupin

TAB

100mg

14

39.54

Lupin

ATORMIN

   

 

 

 

TAB

50mg

14

18.60

PCI

TAB

50mg

30

33.09

PCI

TAB

100mg

14

33.60

PCI

TAB

100mg

30

56.91

PCI

ATPARK

 

 

 

 

TAB

25mg

10

12.91

Parke Davis

TAB

50mg

10

19.90

Parke Davis

TAB

100mg

10

27.64

Parke Davis

BETA

TAB

50mg

14

19.00

Stadmed

TAB

100mg

14

34.50

Stadmed

BETACARD

   

   

   

 

TAB

25mg

14

14.90

Torrent

TAB

50mg

14

19.90

Torrent

TAB

100mg

14

36.90

Torrent

BETANOL

   

  

   

  

TAB

50mg

14

17.50

Unisearch

BETEN

  

  

  

  

TAB

50mg

10 x14

170.00

Sigma

TAB

100mg

14×10

317.80

Sigma

BIDUTEN

 

 

 

 

TAB

50mg

10

16.52

Croydon

BP-NOL

TAB

25mg

10

5.40

Elder

TAB

50mg

10

8.70

Elder

TAB

100mg

10

14.00

Elder

CATENOL

TAB

25mg

14

10.65

Alidac

TAB

50mg

14

20.75

Alidac

TAB

100mg

14

37.60

Alidac

EUCARD

  

 

  

 

TAB

50mg

14

21.00

Malladi Drugs

HIPRES

TAB

25mg

14

11.30

Cipla

TAB

50mg

14

18.65

Cipla

TAB

100mg

14

37.60

Cipla

LAKTEN-50

TAB

50mg

14

21.00

Shalaks

LONOL

  

 

 

  

TAB

25mg

14

12.82

Khandelwal

TAB

50mg

14

20.18

Khandelwal

TAB

100mg

10

16.45

Khandelwal

NORMOLOL

TAB

50mg

10

17.30

Pace(sol)

TAB

100mg

10

23.69

Pace(sol)

PERTENOL

TAB

50mg

14×10

135.00

Karnataka Antibiotics

TAB

100mg

14×10

245.00

Karnataka Antibiotics

TELOL

 

 

 

 

TAB

50mg

10

10.42

Max

TAB

100mg

10

18.03

Max

TENASE

  

   

  

 

TAB

50mg

10

11.90

Jenburkt

TENOLOL

TAB

25mg

14

13.00

IPCA

TAB

50mg

14

20.90

IPCA

TAB

100mg

14

35.90

IPCA

INJ

5mg

10ml

0.00

IPCA

TENSICARD

 

  

  

 

TAB

25mg

14×10

130.00

Troikaa

TAB

50mg

14×10

200.00

Troikaa

TENSIMIN

  

  

  

         

TAB

50mg

14

19.22

Unique

TAB

100mg

14

31.20

Unique

      Top
 

 

By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on Atenolol

About the Author: