Drug
Information

 






Azithromycin



   











  

Pharmacokinetics


 

The drug is an azalide antibiotic. It is more active against
gram-negative organisms. It is aborbed from the GIT after oral
administration. The blood concentration is low, while the anti-microbial
activity is high. It is concentrated in leukocytes and penetrates the
tissues well and has a long half life.

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Indication and Dosage


 


Oral


General Dosage :


Adults : 500 mg once daily for 3 days or 500 mg once on day 1 and 250 mg
once daily on days 2-5.

Children : Over 6 months, 10 mg/kg O.D for 3 days, or body weight wise
15-25 kg: 200 mg O.D * 3 days; 26-35 kg: 300 mg O.D * 3 days; 36-45 kg:
400 mg O.D * 3 days. Azithromycin is taken 1 hour before or 2 hours after
a meal.


Elderly :
No dose changes needed.


UPPER AND LOWER RESPIRATORY TRACT INFECTIONS, SKIN AND SOFT TISSUE
INFECTIONS, UROGENITAL INFECTIONS INCLUDING GONORRHOEA :
General Dosage.


GENITAL CHLAMYDIAL INFECTIONS :
1.0 g as a single dose.

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Action

 

It
is an immunosuppressant, which is given orally or by IV route. It has
marked effect on T-Lymphocytes and suppresses cell mediated immunity. It
is mainly used to prevent rejection in organ transplantation & also
useful in a variety of auto-immune disorders. It is converted in the body
to the antimetabolite mercaptopurime.

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Interactions

 

Antacids, aluminium and magnesium-containing: Antacids may
decrease the amount of azithromycin in the blood, which may
decrease its potency. Azithromycin should be taken at least 1 hour
before or at least 2 hours after antacids.

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Adverse
Effect & Precautions




Nausea, epigastric
distress, vomiting diarhoea, dizziness, headache and flatulence.
Fever, skin rash, cholestatic jaundice, ototoxicity.


 




Hepatic
disease : Patients with severe hepatic disease may have an
increased risk of adverse effects.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands available in market :













































AZ-1

Kopran


CAPS

250 mg

6

143.00

AZEE

Cipla

CAPS

1000 mg

1

79.50

AZID

Indipharma

CAPS

250 mg

6

110.00

AZIP DRY SYRUP

Indipharma

DRY SYRUP

200 mg / 5 ml

7.5 ml

42.00

DRY SYRUP

200 mg / 5 ml

15 ml

70.00

AZIROX

Dee-Pharma

CAPS

250 mg

10 * 6

1320.00

AZISARA

Sarabhai

CAPS

250 mg

6

132.20

AZITHRAL

Alembic

TAB

250 mg

6

158.00

Liquid

200 mg / 5 ml

7.5 ml

49.80

Liquid

200 mg / 5 ml

15 ml

80.00

KID-TAB

100 mg

3

45.30

TAB

500 mg

3

150.95

AZIWIN

Bal Pharma

TAB

250 mg

6

90.00

DISP-TAB

100 mg

4

39.60

TAB

500 mg

3

90.00

AZIWOK

Wockhardt

TAB

250 mg

6

158.00

Liquid

200 mg / 5 ml

7.5 ml

49.98

SUSP

200 mg / 2.5 m

15 ml

78.00

KID-TAB

100 mg

3

48.00

AZOLIDE

J.K.Ind.

CAPS

250 mg

6

140.00

AZOMAX

Max

CAPS

250 mg

6

144.00

AZYX

BDH

CAPS

250 mg

6

140.91

VICON

Pfizer

TAB

250 mg

6

234.89

TAB

500 mg

6

234.89

VICON POS

Pfizer

SUSP

200 mg / ml

15 ml

99.78

SUSP

200 mg

7.5 ml

59.21








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Drug Information
 


Azithromycin
   

  
Pharmacokinetics

 
The drug is an azalide antibiotic. It is more active against gram-negative organisms. It is aborbed from the GIT after oral administration. The blood concentration is low, while the anti-microbial activity is high. It is concentrated in leukocytes and penetrates the tissues well and has a long half life.

TOP
 

Indication and Dosage
 
Oral

General Dosage :

Adults : 500 mg once daily for 3 days or 500 mg once on day 1 and 250 mg once daily on days 2-5.
Children : Over 6 months, 10 mg/kg O.D for 3 days, or body weight wise 15-25 kg: 200 mg O.D * 3 days; 26-35 kg: 300 mg O.D * 3 days; 36-45 kg: 400 mg O.D * 3 days. Azithromycin is taken 1 hour before or 2 hours after a meal.
Elderly : No dose changes needed.
UPPER AND LOWER RESPIRATORY TRACT INFECTIONS, SKIN AND SOFT TISSUE INFECTIONS, UROGENITAL INFECTIONS INCLUDING GONORRHOEA : General Dosage.
GENITAL CHLAMYDIAL INFECTIONS : 1.0 g as a single dose.

TOP
 

Action
 
It is an immunosuppressant, which is given orally or by IV route. It has marked effect on T-Lymphocytes and suppresses cell mediated immunity. It is mainly used to prevent rejection in organ transplantation & also useful in a variety of auto-immune disorders. It is converted in the body to the antimetabolite mercaptopurime.

TOP
 

Interactions
 
Antacids, aluminium and magnesium-containing: Antacids may decrease the amount of azithromycin in the blood, which may decrease its potency. Azithromycin should be taken at least 1 hour before or at least 2 hours after antacids.

TOP
 

Adverse Effect & Precautions

Nausea, epigastric distress, vomiting diarhoea, dizziness, headache and flatulence. Fever, skin rash, cholestatic jaundice, ototoxicity.
 

Hepatic disease : Patients with severe hepatic disease may have an increased risk of adverse effects.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.

TOP
 

 
Brands available in market :

AZ-1

Kopran

CAPS

250 mg

6

143.00

AZEE

Cipla

CAPS

1000 mg

1

79.50

AZID

Indipharma

CAPS

250 mg

6

110.00

AZIP DRY SYRUP

Indipharma

DRY SYRUP

200 mg / 5 ml

7.5 ml

42.00

DRY SYRUP

200 mg / 5 ml

15 ml

70.00

AZIROX

Dee-Pharma

CAPS

250 mg

10 * 6

1320.00

AZISARA

Sarabhai

CAPS

250 mg

6

132.20

AZITHRAL

Alembic

TAB

250 mg

6

158.00

Liquid

200 mg / 5 ml

7.5 ml

49.80

Liquid

200 mg / 5 ml

15 ml

80.00

KID-TAB

100 mg

3

45.30

TAB

500 mg

3

150.95

AZIWIN

Bal Pharma

TAB

250 mg

6

90.00

DISP-TAB

100 mg

4

39.60

TAB

500 mg

3

90.00

AZIWOK

Wockhardt

TAB

250 mg

6

158.00

Liquid

200 mg / 5 ml

7.5 ml

49.98

SUSP

200 mg / 2.5 m

15 ml

78.00

KID-TAB

100 mg

3

48.00

AZOLIDE

J.K.Ind.

CAPS

250 mg

6

140.00

AZOMAX

Max

CAPS

250 mg

6

144.00

AZYX

BDH

CAPS

250 mg

6

140.91

VICON

Pfizer

TAB

250 mg

6

234.89

TAB

500 mg

6

234.89

VICON POS

Pfizer

SUSP

200 mg / ml

15 ml

99.78

SUSP

200 mg

7.5 ml

59.21


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By |2022-07-20T16:44:50+00:00July 20, 2022|Uncategorized|Comments Off on Azithromycin

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