Drug Information

 




 Baclofen














Pharmacokinetics



After oral administration, it is rapidly an
docmpletely absorbed. It is eliminated from the doy, primarily by
kidneys in an unchanged form. The main metabolite is
pharmacologically  active.

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Indication & Dosage

 


Oral

 


SPASTICITY OF SKELETAL MUSCLE AS SEEN IN SPINAL CORD DISEASE INFECTIONS,
DEGENERATIVE TRAUMATIC AND NEOPLASTIC; MULTIPLE SCLEROSIS, SPASTICITY OF
CEREBRAL ORIGIN:


Adults:

Initially 5mg t.i.d increased at 3 day intervals by 5mg t.i.d to a
max of 30-75mg/day. Some may need upto 200mg/day



Children:

0.75-2.5mg/kg/day. Rough guide in children 1-3 years 10-20mg/day
and for 2-10years 30-70mg/day with max of 70mg/day>



Elderly:

 Start at low doses e.g 5mg/day adn increases gradually.

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Action

Baclofen is an antispastic. It inhibits both monosynaptic
and polysynaptic reflexes at spinal level. It is and anlalog of GABA and
exerts its action by stimulation GABA-B receptor subtype. Baclofen also
acts as a general CNS depressant. 

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Interactions

CNS depressants / Additive CNS depression

MAO Inhibitors /
CNS depression and hypotension


Ticyclic antidepressants / Muscle hypotonia

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Adverse
Effect & Precaution




They are usually transitory
and may be eliminated by reducing the dosage. Rarely they are severe
enough to necessitate withdrawl of the drug. Transient drowsiness,
weakness, fatigue, dizziness, headache, confusion, insomnia. Hypotension,
palpitation, chest pain and syncope. Frequency of micturition, skin
rash, pruritus, weight gain, nasal congestion, nausea, cosntipation,
anorexia, abdominal pain, dry mouth, taste disturbace and diarrhoea.



Precaution: Observe caution while driving or performaing tasks requiring
alertness. 

Renal impairment. Dose should be reduced gradually. There are no studies
of drug use in pregnancy. Safety and efficacy of Baclofen injection has
not been established.

Pregnancy: Safety not established.

Breast Feeding: Use with caution.

Man: May be used in reduced dose.

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Brands available in Market

 

















       
Liofen     Sun Pharma
Tab 10mg 10 50.00
Tab 20mg 10 105.00

Lioresal
    Novartis
Tab 10mg 3×10 180.00
Tab 25mg 3×10 375.00
       





 

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Drug Information
 


 Baclofen

Pharmacokinetics

After oral administration, it is rapidly an docmpletely absorbed. It is eliminated from the doy, primarily by kidneys in an unchanged form. The main metabolite is pharmacologically  active.

TOP
 

Indication & Dosage
 

Oral
 
SPASTICITY OF SKELETAL MUSCLE AS SEEN IN SPINAL CORD DISEASE INFECTIONS, DEGENERATIVE TRAUMATIC AND NEOPLASTIC; MULTIPLE SCLEROSIS, SPASTICITY OF CEREBRAL ORIGIN:

Adults:
Initially 5mg t.i.d increased at 3 day intervals by 5mg t.i.d to a max of 30-75mg/day. Some may need upto 200mg/day

Children:
0.75-2.5mg/kg/day. Rough guide in children 1-3 years 10-20mg/day and for 2-10years 30-70mg/day with max of 70mg/day>

Elderly:
 Start at low doses e.g 5mg/day adn increases gradually.

TOP
 

Action

Baclofen is an antispastic. It inhibits both monosynaptic and polysynaptic reflexes at spinal level. It is and anlalog of GABA and exerts its action by stimulation GABA-B receptor subtype. Baclofen also acts as a general CNS depressant. 

TOP
 

Interactions

CNS depressants / Additive CNS depression MAO Inhibitors / CNS depression and hypotension Ticyclic antidepressants / Muscle hypotonia

TOP
 
 

Adverse Effect & Precaution

They are usually transitory and may be eliminated by reducing the dosage. Rarely they are severe enough to necessitate withdrawl of the drug. Transient drowsiness, weakness, fatigue, dizziness, headache, confusion, insomnia. Hypotension, palpitation, chest pain and syncope. Frequency of micturition, skin rash, pruritus, weight gain, nasal congestion, nausea, cosntipation, anorexia, abdominal pain, dry mouth, taste disturbace and diarrhoea.

Precaution: Observe caution while driving or performaing tasks requiring alertness. 
Renal impairment. Dose should be reduced gradually. There are no studies of drug use in pregnancy. Safety and efficacy of Baclofen injection has not been established.
Pregnancy: Safety not established.
Breast Feeding: Use with caution.
Man: May be used in reduced dose.

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Liofen

 

 

Sun Pharma

Tab

10mg

10

50.00

Tab

20mg

10

105.00

Lioresal

 

 

Novartis

Tab

10mg

3×10

180.00

Tab

25mg

3×10

375.00

 

 

 

 

 

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By |2022-07-20T16:44:50+00:00July 20, 2022|Uncategorized|Comments Off on Baclofen

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