Drug Information

 




 Betamethasone

  












 

Pharmacokinetics

Betamethsone
after penetrating the cell, binds with the specific receptors in the
cytoplasm or the nucleus. After the steroid receptor interaction, the
receptor is activated and the steroid receptor complex binds with the
DNA. This regulates the formation of specific mesenger RNA and later
synthesis of protein. The bio-availablity of Betamethasone is moderate
after oral administration. It is metabolised in the liver by hepatic
enzymes.

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Indication
& Dosage

Oral :

General dosage: 


0.6-7.2ng/day depending on the condition. Dosage requirement are
variable and the dose should be individualized.  A Proper maintenance
should be arrived at by reducing the initial dose slowly. Any withdrawal
should be gradual.

ENDOCRINE DISORDERS. PRIMARY OR SECONDARY ADRENAL DEFICIENCY ;

General dosage in conjunction with a mineralocorticoid. Rheumatoid
conditions Rheumatoid Arthritis, Ankylosing spondylitis, Bursitis,
Tenoskynovitis, Gouty Arthritis, Osteoarthritis: General dosage. 

Collagen diseases systemic lupus erythematosus, acute
rheumatic carditis: General dosage


Skin condition:
General dosage.


Allergic states :
Bornchial Asthama, Severe Allergic conditions,
Dermatitis, Allergic Rhinitis,Drug sensitivity: General dosage.


Ophthalmic conditions :
Severe, Acute or Chronical Allergic and
inflammatory condition involving the eye and adnexa: General doasge.


Haematological diseases :
idiopathic therombocytopenic purpura in adults
auto-immune hemolytic anemia, congenital hypoplastic anemia :
General
dosage 


Neoplastic diseases :
Palliative Management of Leukemia of childhood:
General dosage


G1 Diseases :
Ulcerative colitis, regional enteritis : General dosage


Miscellaneous;
Nephorotic syndorme, Tuberculous, Meningitis along with
Chemotheraphy : General Dosage 



IM/IV :

Suppression of inflammatory and allergic disorders,
Congenital Adrenal Hyperplasia, Cerebaral edema, Bronchial Asthma control:
IM or slow IV or infusion 4-20mg repeated upto 4 times in 24 hours 

Children : (slow IV inj) upto 1 yrs. 1mg. 1-5yrs. 3mg 6-12yrs. 4mg.

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Action

Betamethasone is a derivative of prednisolone with enhanced
anti-inflammatory action and reduced sodium and water-retaining
properties. For replacement therapy, naturally-occurring
glucocorticoids(hydrocortisone) which also have salt-retaining properties
are used. The synthetic analogs are primarily used for their powerful
anti-inflammatory properties. They also modify immune responses.

TOP

   

Interactions

Antacids,
Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone,
Phenytoin, Primidone, Rifampin : these drugs may reduce the
effectiveness of corticosteroids. Amphotericin B : Corticosteroids used
with this drug decreases the amount of potassium in the blood, thus
serious side effects could occur if hypokalemia occurs. . Digitalis
glycosides : Corticosteroids reduce the amount of potassium in the
blood. Digitalis can cause Cardiac arrhythmias if hypokalemia occurs.
Duretics: Using corticosteroids with diuretics may cause the diuretic to
be less effective. Also, corticosteroids may increase the risk of
hypokalemia, which is also a problem with some diuretics. Potassium
supplements or potassium sparing diuretics are used in treating
hypertension in those who have problems maintaining their blood
potassium at a normal level: Corticosteroids may make these drugs less
effective in maintaining the potassium levels. Immunization
(vaccinations) : Immunization should be done with great precaution. Skin
test injections: Corticosteroids may cause false results in skin tests.
Sodium-containing drugs: Corticosteroids cause edema. Excessive sodium
levels may cause hypernatremia, hypertension, and water retention.

TOP

  

Precaution

Allergic reaction
to Betamethasone may occur .Special precautions should be taken in
patients with CCF,hypertension, diabetes, CRF, epilepsy and infections.

Pregancy: Use with caution

Breast Feeding: Use with caution.

Man: May be used.

TOP

   

Brands
available in Market









































Belar

TAB

0.5mg    


20×10

Comed

Belar Frote

 


 

 

F-TAB

1mg


20×10

Comed

Betanelan

 


 

 

TAB

0.5mg


10

Glaxo Allenburys

F-TAB

1mg


10

Glaxo Allenburys

Betnesol

 


 

 

TAB

0.5mg 


10

Glaxo

F-TAB

1mg 


10

Glaxo

Inj

4mg 


1ml

Glaxo

Drops

0.5mg/ml


15ml

Glaxo

Celestone

 


 

 

TAB

0.5mg


240

Fulford

TAB

1mg


100

Fulford

Inj

4mg/ml


2ml

Fulford

Drops

0.5mg/ml


10ml

Fulford

Cortil

 


 

 

TAB

0.5mg


20

Micro Labs

F-TAB

1mg


10

Micro Labs

Solubet

 


 

 

TAB

0.5mg


25×10

Lupin

TAB

1mg


10×10

Lupin

Inj

5mg/ml


3x1ml

Lupin

Drops

0.5mg/ml


10ml

Lupin

Stemin

 


 

 

TAB

0.5mg


20×8

Ind-swift

TAB

1mg


20×8

Ind-swift

Drops

0.5mg/ml


15ml

Ind-swift

Inj

4mg/ml


1mlx1am

Ind-swift

Walacort

 


 

 

TAB

0.5mg


10

Wallace




  



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Drug Information
 


 Betamethasone
  

 
Pharmacokinetics

Betamethsone after penetrating the cell, binds with the specific receptors in the cytoplasm or the nucleus. After the steroid receptor interaction, the receptor is activated and the steroid receptor complex binds with the DNA. This regulates the formation of specific mesenger RNA and later synthesis of protein. The bio-availablity of Betamethasone is moderate after oral administration. It is metabolised in the liver by hepatic enzymes.

TOP
   

Indication & Dosage

Oral :
General dosage: 

0.6-7.2ng/day depending on the condition. Dosage requirement are variable and the dose should be individualized.  A Proper maintenance should be arrived at by reducing the initial dose slowly. Any withdrawal should be gradual.

ENDOCRINE DISORDERS. PRIMARY OR SECONDARY ADRENAL DEFICIENCY ;
General dosage in conjunction with a mineralocorticoid. Rheumatoid conditions Rheumatoid Arthritis, Ankylosing spondylitis, Bursitis, Tenoskynovitis, Gouty Arthritis, Osteoarthritis: General dosage. 
Collagen diseases systemic lupus erythematosus, acute rheumatic carditis: General dosage
Skin condition: General dosage.
Allergic states : Bornchial Asthama, Severe Allergic conditions, Dermatitis, Allergic Rhinitis,Drug sensitivity: General dosage.
Ophthalmic conditions : Severe, Acute or Chronical Allergic and inflammatory condition involving the eye and adnexa: General doasge.
Haematological diseases : idiopathic therombocytopenic purpura in adults auto-immune hemolytic anemia, congenital hypoplastic anemia : General dosage 
Neoplastic diseases : Palliative Management of Leukemia of childhood: General dosage
G1 Diseases : Ulcerative colitis, regional enteritis : General dosage
Miscellaneous; Nephorotic syndorme, Tuberculous, Meningitis along with Chemotheraphy : General Dosage 

IM/IV :
Suppression of inflammatory and allergic disorders, Congenital Adrenal Hyperplasia, Cerebaral edema, Bronchial Asthma control: IM or slow IV or infusion 4-20mg repeated upto 4 times in 24 hours 
Children : (slow IV inj) upto 1 yrs. 1mg. 1-5yrs. 3mg 6-12yrs. 4mg.

TOP
   

Action

Betamethasone is a derivative of prednisolone with enhanced anti-inflammatory action and reduced sodium and water-retaining properties. For replacement therapy, naturally-occurring glucocorticoids(hydrocortisone) which also have salt-retaining properties are used. The synthetic analogs are primarily used for their powerful anti-inflammatory properties. They also modify immune responses.

TOP
   

Interactions

Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone, Rifampin : these drugs may reduce the effectiveness of corticosteroids. Amphotericin B : Corticosteroids used with this drug decreases the amount of potassium in the blood, thus serious side effects could occur if hypokalemia occurs. . Digitalis glycosides : Corticosteroids reduce the amount of potassium in the blood. Digitalis can cause Cardiac arrhythmias if hypokalemia occurs. Duretics: Using corticosteroids with diuretics may cause the diuretic to be less effective. Also, corticosteroids may increase the risk of hypokalemia, which is also a problem with some diuretics. Potassium supplements or potassium sparing diuretics are used in treating hypertension in those who have problems maintaining their blood potassium at a normal level: Corticosteroids may make these drugs less effective in maintaining the potassium levels. Immunization (vaccinations) : Immunization should be done with great precaution. Skin test injections: Corticosteroids may cause false results in skin tests. Sodium-containing drugs: Corticosteroids cause edema. Excessive sodium levels may cause hypernatremia, hypertension, and water retention.

TOP
  

Precaution

Allergic reaction to Betamethasone may occur .Special precautions should be taken in patients with CCF,hypertension, diabetes, CRF, epilepsy and infections.
Pregancy: Use with caution
Breast Feeding: Use with caution.
Man: May be used.

TOP
   

Belar

TAB

0.5mg    

20×10

Comed

Belar Frote

 

 

 

F-TAB

1mg

20×10

Comed

Betanelan

 

 

 

TAB

0.5mg

10

Glaxo Allenburys

F-TAB

1mg

10

Glaxo Allenburys

Betnesol

 

 

 

TAB

0.5mg 

10

Glaxo

F-TAB

1mg 

10

Glaxo

Inj

4mg 

1ml

Glaxo

Drops

0.5mg/ml

15ml

Glaxo

Celestone

 

 

 

TAB

0.5mg

240

Fulford

TAB

1mg

100

Fulford

Inj

4mg/ml

2ml

Fulford

Drops

0.5mg/ml

10ml

Fulford

Cortil

 

 

 

TAB

0.5mg

20

Micro Labs

F-TAB

1mg

10

Micro Labs

Solubet

 

 

 

TAB

0.5mg

25×10

Lupin

TAB

1mg

10×10

Lupin

Inj

5mg/ml

3x1ml

Lupin

Drops

0.5mg/ml

10ml

Lupin

Stemin

 

 

 

TAB

0.5mg

20×8

Ind-swift

TAB

1mg

20×8

Ind-swift

Drops

0.5mg/ml

15ml

Ind-swift

Inj

4mg/ml

1mlx1am

Ind-swift

Walacort

 

 

 

TAB

0.5mg

10

Wallace


  

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By |2022-07-20T16:44:51+00:00July 20, 2022|Uncategorized|Comments Off on Betamethasone

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