Drug Information

     





Betaxolol
 

 











Pharmacokinetics

Betaxolol is completely
absorbed from the gastrointestinal tract and undergoes only minimal
first-pass metabolism, resulting in a high oral bioavailability of 80 to
90%. It has high lipid solubility. Betaxolol is about 50% bound to
plasma proteins. It crosses the placenta and is distributed into breast
milk where higher concentrations have been achieved than in maternal
blood. The plasma elimination half-life of betaxolol ranges from 16 to
20 hours. The primary route of elimination is via hepatic metabolism and
urinary excretion; only about 15% is excreted in the urine as unchanged
drug.

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Indication
& Dosage

Topical :Open Angle Glaucoma: (0.5%) One drop in the
affected eye b.i.d.

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Action

Reduces intraocular pressure by reducing production of
aqueous humor.

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Interactions

Since systemic absorption can
follow ophthalmic use of beta blockers the possibility of interactions
occurring with betaxolol eye drops should also be considered.

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Adverse
Effect & Precaution




Local trasient dsicomfort,
itching, photophobia, erythema, decreased corneal sensitivity, corneal
punctate staining.



Precaution: History of diabetes, cardiac failure chronic obstructive
pulmonary disease, thyrotoxicosis, general anaesthesia. Closed angel
glaucoma.

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Brand
availble in Market







 






Iobet
Drops 0.5%  w/w 5ml FDC
Optipress-s

 
Drops 0.25 % w/w 5ml Cipla




  



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Drug Information
     


Betaxolol 
 

Pharmacokinetics

Betaxolol is completely absorbed from the gastrointestinal tract and undergoes only minimal first-pass metabolism, resulting in a high oral bioavailability of 80 to 90%. It has high lipid solubility. Betaxolol is about 50% bound to plasma proteins. It crosses the placenta and is distributed into breast milk where higher concentrations have been achieved than in maternal blood. The plasma elimination half-life of betaxolol ranges from 16 to 20 hours. The primary route of elimination is via hepatic metabolism and urinary excretion; only about 15% is excreted in the urine as unchanged drug.

TOP
   

Indication & Dosage

Topical :Open Angle Glaucoma: (0.5%) One drop in the affected eye b.i.d.

TOP
    

Action

Reduces intraocular pressure by reducing production of aqueous humor.

TOP
  

Interactions

Since systemic absorption can follow ophthalmic use of beta blockers the possibility of interactions occurring with betaxolol eye drops should also be considered.

TOP
   

Adverse Effect & Precaution

Local trasient dsicomfort, itching, photophobia, erythema, decreased corneal sensitivity, corneal punctate staining.

Precaution: History of diabetes, cardiac failure chronic obstructive pulmonary disease, thyrotoxicosis, general anaesthesia. Closed angel glaucoma.

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Iobet

Drops

0.5%  w/w

5ml

FDC

Optipress-s

 

Drops

0.25 % w/w

5ml

Cipla


  

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By |2022-07-20T16:44:51+00:00July 20, 2022|Uncategorized|Comments Off on Betaxolol

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