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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations
Precautions
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Brands available in Market
Betaxolol is completely absorbed from the gastrointestinal tract and undergoes only minimal first-pass metabolism, resulting in a high oral bioavailability of 80 to 90%. It has high lipid solubility. Betaxolol is about 50% bound to plasma proteins. It crosses the placenta and is distributed into breast milk where higher concentrations have been achieved than in maternal blood. The plasma elimination half-life of betaxolol ranges from 16 to 20 hours. The primary route of elimination is via hepatic metabolism and urinary excretion; only about 15% is excreted in the urine as unchanged drug.
Since systemic absorption can follow ophthalmic use of beta blockers the possibility of interactions occurring with betaxolol eye drops should also be considered.
Local trasient dsicomfort, itching, photophobia, erythema, decreased corneal sensitivity, corneal punctate staining.
Precaution: History of diabetes, cardiac failure chronic obstructive pulmonary disease, thyrotoxicosis, general anaesthesia. Closed angel glaucoma.
