Drug Information

 


  











 

Pharmacokinetics

 


Bisoprolol is almost completely
absorbed from the gastrointestinal tract and undergoes only minimal
first-pass metabolism resulting in an oral bioavailability of about 90%.
Peak plasma concentrations are reached 2 to 4 hours after oral
administration. Bisoprolol is about 30% bound to plasma proteins. It has
a plasma elimination half-life of 10 to 12 hours. Bisoprolol is
moderately lipid-soluble. Approximately 50% of a dose is metabolised in
the liver and it is excreted in urine as unchanged drug and metabolites. 

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Indication and Dosage




Hypetension, Coronary Artery
Disease.

Dosage: Adults: 5mg od; increase to 5mg twice daily, if reqd 

Children: Not recommended.

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Interactions

 


Alchol, Anxiolytics and Hypnotics,
Cimetidine, Diuretics: Enhanced hypotensive effect.

Analgesic: NSAIDs antagonise hypotensive effect.

Antidiabetics: Enhanced hypoglycaemic effect.

Calcium channel blockers: Increase risk of bradycardia and AV block with
ditiazem, severe hypotension and heart failure with verapamil, nifedipine.

Cardiac glycosides: Increased AV-Block and brandycardia.

Cholinergics: Effects antagonised by bisoprolol.

Carticosteriods: Antagonism of hypotensive effect.

Sympathomimetics: Severe hypertension with adrenaline and noradrenaline.

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Adverse Effect & Precaution



Fatigue, nausea, vomiting, giddiness,
headache, cold extremites, breathlessness, bradycardia.

Precaution: Diabetes, renal dysfunction, asthma, left ventricular failure,
abrupt withdrawal, thyrotoxicosis.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands available in market 


 





CONCOR

E.Merck
TAB 10 5mg 81.05



  



 

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Drug Information
 

  

 
Pharmacokinetics
 

Bisoprolol is almost completely absorbed from the gastrointestinal tract and undergoes only minimal first-pass metabolism resulting in an oral bioavailability of about 90%. Peak plasma concentrations are reached 2 to 4 hours after oral administration. Bisoprolol is about 30% bound to plasma proteins. It has a plasma elimination half-life of 10 to 12 hours. Bisoprolol is moderately lipid-soluble. Approximately 50% of a dose is metabolised in the liver and it is excreted in urine as unchanged drug and metabolites. 

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Indication and Dosage

Hypetension, Coronary Artery Disease.
Dosage: Adults: 5mg od; increase to 5mg twice daily, if reqd 
Children: Not recommended.

TOP
 

Interactions
 

Alchol, Anxiolytics and Hypnotics, Cimetidine, Diuretics: Enhanced hypotensive effect.
Analgesic: NSAIDs antagonise hypotensive effect.
Antidiabetics: Enhanced hypoglycaemic effect.
Calcium channel blockers: Increase risk of bradycardia and AV block with ditiazem, severe hypotension and heart failure with verapamil, nifedipine.
Cardiac glycosides: Increased AV-Block and brandycardia.
Cholinergics: Effects antagonised by bisoprolol.
Carticosteriods: Antagonism of hypotensive effect.
Sympathomimetics: Severe hypertension with adrenaline and noradrenaline.

TOP
 

Adverse Effect & Precaution

Fatigue, nausea, vomiting, giddiness, headache, cold extremites, breathlessness, bradycardia.
Precaution: Diabetes, renal dysfunction, asthma, left ventricular failure, abrupt withdrawal, thyrotoxicosis.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.

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CONCOR

E.Merck

TAB

10

5mg

81.05

  

 

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