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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interaction
Precautions |
Brands available in Market
Pharmacokinetics
The loop agents are rapidly absorbed and handled by renal excretion . Duration of effect is for 3 to 4 hrs.
Loop diuretics are used to reduce oedema states . They work by inhibiting the reabsorbtion of Sodium and Chloride predominantly in the Loop of Henle. It is used to treat the oedema asscociated with congestive cardiac failure, hepatic and renal disease including nephrotic syndrome.For oral dosage form (tablets): Adults: 0.5 to 2 milligrams (mg) once a day. For injection dosage form: Adults : 0.5 to 1 mg injected IM or IV every three to six hours as needed.
Inhibits reabsorption of both sodium and chloride in the proximal tubule as well as the ascending loop of Henle. Possible activity in the proximal tubule to promote phosphate excretion. Onset, PO: 30-60 min. Peak effect, PO: 1-2 hr. Duration, PO: 4-6 hr (dose-dependent). Onset, IV: Several minutes. Peak effect, IV: 15-30 min. Duration, IV: 3.5-4 hr. t1/2: 1-1.5 hr. Metabolized in the liver although 45% excreted unchanged in the urine.
It may increase the nephro-toxicity of cephalosporins and aminoglycosides. Phenytoin and indomethacin decrease the effect of bumetanide. Analgesics may reduce the natriuretic effect. Bumetanide enhances the activity of muscle relaxants.
Allergies :Allergic reactions to the drug may occur. Pregnancy: In general, diuretics are not useful for edema of feet and hands that occur during pregnancy. Diuretics should not be taken during pregnancy. Older adults: Dizziness, lightheadedness, or signs of hypokalemia may be more likely to occur in the elderly, who are more sensitive to the effects of loop diuretics. Elderly patients may also be more likely to develop thrombii.
