Drug Information

 


    













  

Pharmacokinetics

The loop
agents are rapidly absorbed and handled by renal excretion . Duration of
effect is for 3 to 4 hrs.




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Indication
& Dosage

Loop diuretics
are used to reduce oedema states . They work by inhibiting the
reabsorbtion of Sodium and Chloride predominantly in the Loop of Henle.
It is used to treat the oedema asscociated with congestive cardiac
failure, hepatic and renal disease including nephrotic syndrome.For oral
dosage form (tablets): Adults: 0.5 to 2 milligrams (mg) once a day. For
injection dosage form: Adults : 0.5 to 1 mg injected IM or IV every
three to six hours as needed.

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Action

Inhibits reabsorption of both
sodium and chloride in the proximal tubule as well as the ascending loop
of Henle. Possible activity in the proximal tubule to promote phosphate
excretion. Onset, PO: 30-60 min. Peak effect, PO: 1-2 hr. Duration, PO:
4-6 hr (dose-dependent). Onset, IV: Several minutes. Peak effect, IV:
15-30 min. Duration, IV: 3.5-4 hr. t1/2: 1-1.5 hr. Metabolized
in the liver although 45% excreted unchanged in the urine.

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Interaction

It may
increase the nephro-toxicity of cephalosporins and aminoglycosides.
Phenytoin and indomethacin decrease the effect of bumetanide. Analgesics
may reduce the natriuretic effect. Bumetanide enhances the activity of
muscle relaxants.

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Precaution

Allergies
:Allergic reactions to the drug may occur. Pregnancy: In general,
diuretics are not useful for edema of feet and hands that occur during
pregnancy. Diuretics should not be taken during pregnancy. Older adults:
Dizziness, lightheadedness, or signs of hypokalemia may be more likely
to occur in the elderly, who are more sensitive to the effects of loop
diuretics. Elderly patients may also be more likely to develop thrombii.

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Brands
available in Market






 





Bumet     Montari
TAB 1mg 10 4.75




  



 

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Drug Information
 

    

  
Pharmacokinetics

The loop agents are rapidly absorbed and handled by renal excretion . Duration of effect is for 3 to 4 hrs.


TOP
   

Indication & Dosage

Loop diuretics are used to reduce oedema states . They work by inhibiting the reabsorbtion of Sodium and Chloride predominantly in the Loop of Henle. It is used to treat the oedema asscociated with congestive cardiac failure, hepatic and renal disease including nephrotic syndrome.For oral dosage form (tablets): Adults: 0.5 to 2 milligrams (mg) once a day. For injection dosage form: Adults : 0.5 to 1 mg injected IM or IV every three to six hours as needed.

TOP
   

Action

Inhibits reabsorption of both sodium and chloride in the proximal tubule as well as the ascending loop of Henle. Possible activity in the proximal tubule to promote phosphate excretion. Onset, PO: 30-60 min. Peak effect, PO: 1-2 hr. Duration, PO: 4-6 hr (dose-dependent). Onset, IV: Several minutes. Peak effect, IV: 15-30 min. Duration, IV: 3.5-4 hr. t1/2: 1-1.5 hr. Metabolized in the liver although 45% excreted unchanged in the urine.

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Interaction

It may increase the nephro-toxicity of cephalosporins and aminoglycosides. Phenytoin and indomethacin decrease the effect of bumetanide. Analgesics may reduce the natriuretic effect. Bumetanide enhances the activity of muscle relaxants.

TOP
    

Precaution

Allergies :Allergic reactions to the drug may occur. Pregnancy: In general, diuretics are not useful for edema of feet and hands that occur during pregnancy. Diuretics should not be taken during pregnancy. Older adults: Dizziness, lightheadedness, or signs of hypokalemia may be more likely to occur in the elderly, who are more sensitive to the effects of loop diuretics. Elderly patients may also be more likely to develop thrombii.

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Bumet

 

 

Montari

TAB

1mg

10

4.75


  

 

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By |2022-07-20T16:44:48+00:00July 20, 2022|Uncategorized|Comments Off on Bumetanide

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