Drug Information

 




     





 








 

Pharmacokinetics

Bupivacaine is
about 95% bound to plasma proteins. Reported half-lives are from 1.5 to
5.5 hours in adults and about 8 hours in neonates. It is metabolised in
the liver and is excreted in the urine principally as metabolites with
only 5 to 6% as unchanged drug.

Bupivacaine is
distributed into breast milk in small quantities. It crosses the
placenta but the ratio of fetal concentrations to maternal
concentrations is relatively low. Bupivacaine also diffuses into the
cerebrospinal fluid.

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Indication & Dosage



Infiltration anaesthesia, epidural and spinal aesthesia, nerver block.

Dosage: Max. dose is 150mg a 4-hour period.

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Action

Blocks the generation and conduction of nerve impulses.
Order of loss of function is as follows: Pain, temperature, touch,
proprioception, and skeletal muscle tone. Toxic levels may depress cardiac
conduction, excitability, and cardiac arrest.

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Interactions

Local infiltration :
Caudal, Epidural, Peripheral
nerve block when muscular relaxation is not important : 0.25% solution.

where some muscular relaxation is needed : 0.5% solution

Either strength can be gicen for local infiltration for painful
musculoskeletal disorders, incisional, infiltration for postoperative pain
relief etc : Dosage varies with individual patients, vascularity of the
region and rat of absorption. Doses upto 225mg of bupivacaine with
adrenaline or 175mg without adrenaline may be used. For epidural block 5%
solution can be accidental intra-vascular or intrathecal injection 



Spinal :

Spinal Anaesthesia: Bupivacaine 5%+dextrose 80mg/m 7.5-12mg of
bupivacaine can be used for spinal anaesthesia for lower extremities and
perineal procedures and vaginal hysterectomy.

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Adverse
Effect & Precaution




Cardiac arrest, cardiac arrhythmias, respitatory failure.

Precaution: Heart block, hepatic dysfunction, shock, heart disease,
debililated patients

Pregnancy: Caution, use only when clearly
indicated.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands available in Market

 

















Anawin

INJ

5mg/ml

20ml

Neon Labs

Anawin heavy

 

 

 

INJ

 

5x4ml

Neon Labs

Sensoracaine

 

 

 

VIAL

0.25%

20ml

Astra-IDL

VIAL

0.5%

20ml

Astra-IDL

Sensorcaine heavy

 

 

 

INJ

0.5%

5x4ml

Astra-IDL

Sensorcaine spinal

 

 

 

INJ 

0.5%

5x4ml

Astra-IDL


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Drug Information
 


     

 

 
Pharmacokinetics

Bupivacaine is about 95% bound to plasma proteins. Reported half-lives are from 1.5 to 5.5 hours in adults and about 8 hours in neonates. It is metabolised in the liver and is excreted in the urine principally as metabolites with only 5 to 6% as unchanged drug.

Bupivacaine is distributed into breast milk in small quantities. It crosses the placenta but the ratio of fetal concentrations to maternal concentrations is relatively low. Bupivacaine also diffuses into the cerebrospinal fluid.

TOP
 

Indication & Dosage

Infiltration anaesthesia, epidural and spinal aesthesia, nerver block.
Dosage: Max. dose is 150mg a 4-hour period.

TOP
 

Action

Blocks the generation and conduction of nerve impulses. Order of loss of function is as follows: Pain, temperature, touch, proprioception, and skeletal muscle tone. Toxic levels may depress cardiac conduction, excitability, and cardiac arrest.

TOP
 

Interactions

Local infiltration : Caudal, Epidural, Peripheral nerve block when muscular relaxation is not important : 0.25% solution.
where some muscular relaxation is needed : 0.5% solution
Either strength can be gicen for local infiltration for painful musculoskeletal disorders, incisional, infiltration for postoperative pain relief etc : Dosage varies with individual patients, vascularity of the region and rat of absorption. Doses upto 225mg of bupivacaine with adrenaline or 175mg without adrenaline may be used. For epidural block 5% solution can be accidental intra-vascular or intrathecal injection 

Spinal :
Spinal Anaesthesia: Bupivacaine 5%+dextrose 80mg/m 7.5-12mg of bupivacaine can be used for spinal anaesthesia for lower extremities and perineal procedures and vaginal hysterectomy.

TOP
 

Adverse Effect & Precaution

Cardiac arrest, cardiac arrhythmias, respitatory failure.
Precaution: Heart block, hepatic dysfunction, shock, heart disease, debililated patients
Pregnancy: Caution, use only when clearly indicated.
Breast Feeding: Use with caution.
Man: Use with caution.

TOP
 

Anawin

INJ

5mg/ml

20ml

Neon Labs

Anawin heavy

 

 

 

INJ

 

5x4ml

Neon Labs

Sensoracaine

 

 

 

VIAL

0.25%

20ml

Astra-IDL

VIAL

0.5%

20ml

Astra-IDL

Sensorcaine heavy

 

 

 

INJ

0.5%

5x4ml

Astra-IDL

Sensorcaine spinal

 

 

 

INJ 

0.5%

5x4ml

Astra-IDL

TOP  

                                  

 

By |2022-07-20T16:44:48+00:00July 20, 2022|Uncategorized|Comments Off on Bupivacaine

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