Drug Information

 


      





 








 

Pharmacokinetics

Buprenorphine can be given orally, IM, and sublingually. 50 % of the
drug is bio-available after sublingual administration. It is highly
protein bound and remains in the tissues for several days. It is mainly
excreted in the faeces and in smaller amounts in the urine.

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Indication & Dosage

IM / IV :

Moderate severe pain, Cancer pain, Burns, Post Operative pain and pain
and pain due to ami, premedication before surgery : 0.3% (in 1ml) by deep
1M or slow IV(over 2 min) injection. May be repeated 6-8 hrs. up to
maximum of 6ml (1.8mg) 

Children 2-12yrs : 2-6mcg/kg may be repeated with caution 6-8 hourly.



Sublingual :

Moderate to severe pain : 0.2-0.4mg every 6-8hrs 

Children : 0.1-0.2mg depending on b.w.

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Action

Buprenophin binds to mu-subclass of opioid receptors in the
CNS. It has a longer duration of analgesic action than morphine. Its
partial agonist activity gives a low level of physical dependence.
Buprenorphine and morphine show similar dose-related respiratory effect.

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Interactions

May precipitate withdrawal symptoms in narcotic
addicts. When given along with diazepam may produce respiratory and
cardiac collapse.

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Precaution



Dizziness, sedation, miosis, respiratory depression, sweating, nausea
and vomiting

Special precaution to be taken in hepatic disease,renal disease and
lactation.

Pregnancy: Contraindicated

Breast Feeding: Use with caution.

Man: May be given in reduced dose

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Brands available in Market






 

















Buprigesic

INJ

0.3mg/ml

10x2ml

Neon

INJ

0.3mg/ml

10x1ml

Neon

Norphin

 

 

 

INJ

0.3mg/ml

2ml

1mlUnichem

INJ

0.3mg/ml

1ml

Unichem

INJ

200mcg

10

Unichem

Pentorel

 

 

 

INJ

0.3mg

1ml

Khandelwal

INJ

0.3mg/ml 

2ml

Khandelwal

Tidigesic

 

 

 

SL-TAB

0.2mg

10

Sun Pharma

INJ

0.3mg/ml

1ml

Sun Pharma

INJ

0.3mg/ml

2ml

Sun Pharma




 
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Drug Information
 

      

 

 
Pharmacokinetics

Buprenorphine can be given orally, IM, and sublingually. 50 % of the drug is bio-available after sublingual administration. It is highly protein bound and remains in the tissues for several days. It is mainly excreted in the faeces and in smaller amounts in the urine.

Top 
 

Indication & Dosage

IM / IV :
Moderate severe pain, Cancer pain, Burns, Post Operative pain and pain and pain due to ami, premedication before surgery : 0.3% (in 1ml) by deep 1M or slow IV(over 2 min) injection. May be repeated 6-8 hrs. up to maximum of 6ml (1.8mg) 

Children 2-12yrs : 2-6mcg/kg may be repeated with caution 6-8 hourly.

Sublingual :
Moderate to severe pain : 0.2-0.4mg every 6-8hrs 
Children : 0.1-0.2mg depending on b.w.

Top 
 

Action

Buprenophin binds to mu-subclass of opioid receptors in the CNS. It has a longer duration of analgesic action than morphine. Its partial agonist activity gives a low level of physical dependence. Buprenorphine and morphine show similar dose-related respiratory effect.

Top 
 
 

Interactions

May precipitate withdrawal symptoms in narcotic addicts. When given along with diazepam may produce respiratory and cardiac collapse.

Top 
   

Precaution

Dizziness, sedation, miosis, respiratory depression, sweating, nausea and vomiting

Special precaution to be taken in hepatic disease,renal disease and lactation.
Pregnancy: Contraindicated
Breast Feeding: Use with caution.
Man: May be given in reduced dose

Top  
    

 

Buprigesic

INJ

0.3mg/ml

10x2ml

Neon

INJ

0.3mg/ml

10x1ml

Neon

Norphin

 

 

 

INJ

0.3mg/ml

2ml

1mlUnichem

INJ

0.3mg/ml

1ml

Unichem

INJ

200mcg

10

Unichem

Pentorel

 

 

 

INJ

0.3mg

1ml

Khandelwal

INJ

0.3mg/ml 

2ml

Khandelwal

Tidigesic

 

 

 

SL-TAB

0.2mg

10

Sun Pharma

INJ

0.3mg/ml

1ml

Sun Pharma

INJ

0.3mg/ml

2ml

Sun Pharma


 
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By |2022-07-20T16:44:48+00:00July 20, 2022|Uncategorized|Comments Off on Buprenorphine

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