Drug Information

 


   






   

Pharmacokinetics


 



Captopril is rapidly absorbed after oral administration with
bioavailability of 70%. It is highly protein bound. It is excreted via
Kidneys.

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Indication &
Dosage


 


Oral

HYPERTENSION:
Mild to moderate: 25-50mg t.i.d. Moderate to severe
50-100mg t.i.d

CONGESTIVE FAILURE: Start with 6.25-12.5mg. Build up to
maintenance dose of 25mg 2 or 3 times/day. Max daily dose 150mg.
Children: 1-6mg/kg daily in divided dose. Eldery: Start with lower dose
and build up gradually. Renal impairment: Start with low doses and build
up slowly. Captorpril may be combined with diuretic and other
antihypertensives

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Action

 

Captopril inhibits angiotension converting enzyme which
has two-fold effect; reduction of angiotension II levels (ATII) and
increase of bradykinin levels. Both contribute to fall in BP, the former
to a greater extent. Reduction of ATII also reduces Aldosterone and
sodium and water retention. By these mechanisms captopril produces a
hypotensive effect and a beneficial effect in congestive heart failure.

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Interactions

Risk of bone marrow depression when used with
immunosupressive agents. Causes hyperkalaemia with potassium sparing
diuretics. NSAID’s may block the hypotensive action of Captopril.

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Adverse
Effect & Precaution




Dry coug, skin rash, loss of
taste, hyprkalaemia, vertigo, headache, nausea, vomiting, hypotension,
fatigue, neutropenia, (rare), proteinuria, anaemia

Allergies: Allergic reaction to captopril may occur.
Pregnancy: Studies in animals at doses up to 400 times the human dose
have shown that captopril causes an increase in deaths of the foetus and
new born. Also, captopril has caused deformed skulls in the offspring of
rabbits given doses 2 to 70 times the recommended human dose.
Breast-feeding : captopril passes into breast milk.Children : Children
may be especially sensitive to the hypotensive effect of ACE inhibitors.
This may increase the chance of adverse effects during treatment.
Adults: This drug has been tested in patients 65 years of age or older
and has not been shown to cause any different side effects or problems
in older people than it does in younger adults.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: May be used with caution.

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Brands
available in Market


 

ACETEN      


wochardt

TAB                       

25mg

10

35.00


ANGIOPRIL

Torrent

TAB

25mg

10

27.90

TAB

50mg

10

48.50


CAPOTRIL


Lupin

TAB

12.5mg

10

15.78

TAB

25mg

10

32.83




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Drug Information
 

   

   
Pharmacokinetics

 

Captopril is rapidly absorbed after oral administration with bioavailability of 70%. It is highly protein bound. It is excreted via Kidneys.

Top
  

Indication & Dosage
 
Oral
HYPERTENSION:
Mild to moderate: 25-50mg t.i.d. Moderate to severe 50-100mg t.i.d
CONGESTIVE FAILURE: Start with 6.25-12.5mg. Build up to maintenance dose of 25mg 2 or 3 times/day. Max daily dose 150mg. Children: 1-6mg/kg daily in divided dose. Eldery: Start with lower dose and build up gradually. Renal impairment: Start with low doses and build up slowly. Captorpril may be combined with diuretic and other antihypertensives

Top
  

Action
 
Captopril inhibits angiotension converting enzyme which has two-fold effect; reduction of angiotension II levels (ATII) and increase of bradykinin levels. Both contribute to fall in BP, the former to a greater extent. Reduction of ATII also reduces Aldosterone and sodium and water retention. By these mechanisms captopril produces a hypotensive effect and a beneficial effect in congestive heart failure.

Top
  

Interactions

Risk of bone marrow depression when used with immunosupressive agents. Causes hyperkalaemia with potassium sparing diuretics. NSAID’s may block the hypotensive action of Captopril.

Top
  

Adverse Effect & Precaution

Dry coug, skin rash, loss of taste, hyprkalaemia, vertigo, headache, nausea, vomiting, hypotension, fatigue, neutropenia, (rare), proteinuria, anaemia

Allergies: Allergic reaction to captopril may occur. Pregnancy: Studies in animals at doses up to 400 times the human dose have shown that captopril causes an increase in deaths of the foetus and new born. Also, captopril has caused deformed skulls in the offspring of rabbits given doses 2 to 70 times the recommended human dose. Breast-feeding : captopril passes into breast milk.Children : Children may be especially sensitive to the hypotensive effect of ACE inhibitors. This may increase the chance of adverse effects during treatment. Adults: This drug has been tested in patients 65 years of age or older and has not been shown to cause any different side effects or problems in older people than it does in younger adults.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: May be used with caution.

Top
  

ACETEN      

wochardt

TAB                       

25mg

10

35.00

ANGIOPRIL

Torrent

TAB

25mg

10

27.90

TAB

50mg

10

48.50

CAPOTRIL

Lupin

TAB

12.5mg

10

15.78

TAB

25mg

10

32.83

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By |2022-07-20T16:44:48+00:00July 20, 2022|Uncategorized|Comments Off on Captopril

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