Drug Information

  


   








   

Pharmacokinetics

It has slower
absorption in the gut .It is 75 % bound to plasma proteins. metabolised
in the Liver by oxidative enzymes.Plasma half life is 20 to 40 hrs but
decreases on chronic administration.

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Indication & Dosage




Oral

EPILEPSY, MANIAM TRIGEMINAL NEURALGIA, PAINFUL DIABETIC
NEUROPATHIES, ALCOHOL WITHDRAWAL SYNDROME:
Adult: Initially 20mg b.i.d
increments of 200mg/day once a week upto 800mg b.i.d. Children: Upto 1
year: 100-200mg/day. 1-5 yrs: 100mg/day increased upto 400mg/day
increased upto 300mg b.i.d. 11-15 yrs: 600mg/day increased upto
12000mg/day. Sustained release(for epilepsy): Intially 200mg b.i.d.
increased to 400-800mg b.i.d. CHILDREN: Start with 100mg/day 1-5yrs:
100mg b.i.d. increased if reqd. to 200-400mg. 5-10 yrs: 200mg b.i.d.
increased to 300mg in the morning and 300mg in the evening as reqd.
10-15yrs: Starting dose 600mg increased if reqd. upto 1200mg/day.

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Action

 


Carbamazepine reduces polysnaptic responses and blocks post-tetanic
potentiation. Effective in partial and generalised convulsions and in
mixed types. Carbamazepine is not effective in petit mal seizures.
Carbamazepine reduces or abolishes pain in trigeminal neralgia and
glosso-pharyngeal neralgia.

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Interactions

 


Carbamazepine is an enzyme inducer.Its metabolism is induced by
phenobarbitone, phenytoin, valproate and vice versa. It has also been
found to reduce the blood levels of valproic acid. Erythromycin inhibits
the metabolism of carbamazepine. By enzyme induction it reduces the
efficacy of oral contraceptives.

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Adverse
Effect & Precaution




12-24 hours ataxia,
drowsiness, blurred vision, nausea, epigastric distress and vomiting.
Morbilliform rash occur in 5-10% patients. The other uncommon side
effects are bone marrow depression, thrombocytopenic purpura and
cholestatic jaundice. It may cause leukopenia and aplastic anaemia.
Hypersensitivity to structurally related compunds (e.g Tricyclic
antidepressants).

 


Allergies – May
sometimes occur with this drug. In older adults – Confusion,
restlessness and nervousness, arrhythmias, bradycardia, palpitation and
angina pectoris are more likely to occur .Adverse reactions like
aplastic anaemia,hepatitis, steven-johnson syndrome have been
reported.Pregnancy – There are reports of babies having low birth
weight, small head size, skull and facial defects, underdeveloped
fingernails, and delays in growth, when their mothers had taken
carbamazepine in high doses during pregnancy. Studies in animals have
revealed that carbamazepine causes birth defects when given in large
doses. Therefore, the use of carbamazepine during pregnancy should be
treated with caution. Breast-feeding – Carbamazepine passes into the
breast milk, and in some cases the baby may receive sufficient amounts
to cause adverse effects. Children – Behavior changes are more likely to
occur in children.

Pregnancy: May lead to teratogenic effects, usually not prescribed.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.

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CARBAZIN

Saga Labs
TAB 200mg 10 17.28
CARMAZ

Natco

TAB 100mg 10 9.50
TAB 200mg 10 18.00
CARMAZ KID

Natco
DIS-TAB 100MG 10 15.00
EPINIL

Themis Pharma
TAB 100mg 10 9.24
TAB 200mg 10 17.96
MAZETOL

SPPL
TAB 200mg 10×10 174.56
TAB 200mg 10×10 343.66
SYRUP 100mg/5ml 100ml 40.27
TAB 100mg 10×10 92.79
SR-TAB 200mg 10×10 203.24
SR-TAB 200mg 10×10 393.29
MAZETOL SR-200

SPPL
SR TAB 200mg 10×10 203.24
MAZETOL SR-400 400mg

SPPL
SR TAB 400mg 10×10 393.29
MEZAPIN

LA Pharma
TAB 200mg 10 14.00
TEGRETOL

Novartis
CHEW TAB 100mg 10×10 68.74
TAB 200mg 10 18.47
TAB 400mg 10 36..04
SYRUP 20mg/ml 100ml 35.93
VERSIZUR

Micro Lab
TAB 200mg 10 10.00
ZEN RETARD


CR TAB 200mg 10 20.26
CR TAB 400mg 10 39.21
ZEN-100

Intas
TAB 100mg 10 8.92
ZEN-200

Intas
TAB 200mg 10 17.39
ZEPTOL

Sun Pharma
TAB 100mg 10 6.55
TAB 200mg 10 17.54
TAB 400mg 10 16.87




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 Drug Information
  

   

   
Pharmacokinetics

It has slower absorption in the gut .It is 75 % bound to plasma proteins. metabolised in the Liver by oxidative enzymes.Plasma half life is 20 to 40 hrs but decreases on chronic administration.

Top
 

Indication & Dosage

Oral
EPILEPSY, MANIAM TRIGEMINAL NEURALGIA, PAINFUL DIABETIC NEUROPATHIES, ALCOHOL WITHDRAWAL SYNDROME:
Adult: Initially 20mg b.i.d increments of 200mg/day once a week upto 800mg b.i.d. Children: Upto 1 year: 100-200mg/day. 1-5 yrs: 100mg/day increased upto 400mg/day increased upto 300mg b.i.d. 11-15 yrs: 600mg/day increased upto 12000mg/day. Sustained release(for epilepsy): Intially 200mg b.i.d. increased to 400-800mg b.i.d. CHILDREN: Start with 100mg/day 1-5yrs: 100mg b.i.d. increased if reqd. to 200-400mg. 5-10 yrs: 200mg b.i.d. increased to 300mg in the morning and 300mg in the evening as reqd. 10-15yrs: Starting dose 600mg increased if reqd. upto 1200mg/day.

Top
 

Action
 

Carbamazepine reduces polysnaptic responses and blocks post-tetanic potentiation. Effective in partial and generalised convulsions and in mixed types. Carbamazepine is not effective in petit mal seizures. Carbamazepine reduces or abolishes pain in trigeminal neralgia and glosso-pharyngeal neralgia.

Top
 

Interactions
 

Carbamazepine is an enzyme inducer.Its metabolism is induced by phenobarbitone, phenytoin, valproate and vice versa. It has also been found to reduce the blood levels of valproic acid. Erythromycin inhibits the metabolism of carbamazepine. By enzyme induction it reduces the efficacy of oral contraceptives.

Top
 

Adverse Effect & Precaution

12-24 hours ataxia, drowsiness, blurred vision, nausea, epigastric distress and vomiting. Morbilliform rash occur in 5-10% patients. The other uncommon side effects are bone marrow depression, thrombocytopenic purpura and cholestatic jaundice. It may cause leukopenia and aplastic anaemia. Hypersensitivity to structurally related compunds (e.g Tricyclic antidepressants).
 

Allergies – May sometimes occur with this drug. In older adults – Confusion, restlessness and nervousness, arrhythmias, bradycardia, palpitation and angina pectoris are more likely to occur .Adverse reactions like aplastic anaemia,hepatitis, steven-johnson syndrome have been reported.Pregnancy – There are reports of babies having low birth weight, small head size, skull and facial defects, underdeveloped fingernails, and delays in growth, when their mothers had taken carbamazepine in high doses during pregnancy. Studies in animals have revealed that carbamazepine causes birth defects when given in large doses. Therefore, the use of carbamazepine during pregnancy should be treated with caution. Breast-feeding – Carbamazepine passes into the breast milk, and in some cases the baby may receive sufficient amounts to cause adverse effects. Children – Behavior changes are more likely to occur in children.
Pregnancy: May lead to teratogenic effects, usually not prescribed.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top
 

CARBAZIN

Saga Labs

TAB

200mg

10

17.28

CARMAZ

Natco

TAB

100mg

10

9.50

TAB

200mg

10

18.00

CARMAZ KID

Natco

DIS-TAB

100MG

10

15.00

EPINIL

Themis Pharma

TAB

100mg

10

9.24

TAB

200mg

10

17.96

MAZETOL

SPPL

TAB

200mg

10×10

174.56

TAB

200mg

10×10

343.66

SYRUP

100mg/5ml

100ml

40.27

TAB

100mg

10×10

92.79

SR-TAB

200mg

10×10

203.24

SR-TAB

200mg

10×10

393.29

MAZETOL SR-200

SPPL

SR TAB

200mg

10×10

203.24

MAZETOL SR-400

400mg

SPPL

SR TAB

400mg

10×10

393.29

MEZAPIN

LA Pharma

TAB

200mg

10

14.00

TEGRETOL

Novartis

CHEW TAB

100mg

10×10

68.74

TAB

200mg

10

18.47

TAB

400mg

10

36..04

SYRUP

20mg/ml

100ml

35.93

VERSIZUR

Micro Lab

TAB

200mg

10

10.00

ZEN RETARD

CR TAB

200mg

10

20.26

CR TAB

400mg

10

39.21

ZEN-100

Intas

TAB

100mg

10

8.92

ZEN-200

Intas

TAB

200mg

10

17.39

ZEPTOL

Sun Pharma

TAB

100mg

10

6.55

TAB

200mg

10

17.54

TAB

400mg

10

16.87

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By |2022-07-20T16:41:35+00:00July 20, 2022|Uncategorized|Comments Off on Carbamazepine

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