Drug Information

  


   






   

Pharmacokinetics

 


After oral administration rapidly and extensively absorb.
Metabolism is primarily hepatic.

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Indication
& Dosage


 


Oral

HYPERTENSION:
Initially 6.25mg
b.i.d. for 7-14 days, later increased to 12.5mg for 7-14 days if
required. Max. daily dose 50mg

CONGESTIVE HEART FAILURE: Initially
3,125mg b.i.d for 2 weeks. If well tolerated increased to 6.25mg
b.i.d, later increased at doublefold every two weeks as tolerated
by the patient. Patients below 80kgs; Max. 25mg b.i.d; Patients
above 80kgs: Max. 50mg b.i.d. Dose increase not to be done until
symptoms of congestive heart failure or vasodilation stabilise.

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Action

 


Carvedilol, an arylethanolamine is a non specific adrenoreceptor
antagonist with alpha- 1 blocking acitvity. It exerts
antihypertensive effect partly by reducing total peripheral
resistance and vasodilation, by blocking alpha-adrenoreceptor and
partly by inhibiting beta-adrenoreceptor mediated compensatory
mechanisms. the nonspecific action also avoid utoward effects
associated with conventional beta blocker or vasodialator therapy,
also suited for the management of patients with renal impairment,
NIDDM or IDDM. Has no adverse effects on plasma lipid profiles.

 




Interactions

 


Antidiabetic agents: Effects of insulin and oral hypoglycaemics
enhaced.

Calcium blockers: Isolated case of conduction disturbance have
been observed.

Clonidine: Blood pressure and heart rate lowering effects
potentiated.

Digoxin: Serum concentrations of digoxin are increased requiring
monitoring of digoxin.

Rifampicin: Plasma concentration of carvedilol reduced by 70%.

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Adverse
Effect & Precautions

 


Postural hyypotension, dizziness, headache, fatigue, GI
disturbance, dry eyes.



Abrupt withdrawal. Initial treatment with low dose. Avoid driving
or operating hazardous machinery. Patients with bronchospastic
disease and elderly.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands
available in Market


 
CARCA   Intas
TAB 12.5mg 10 26.00
CARDIVAS     Sun
TAB 12.5mg 10 99.00
CARVETREND     Nicholas
TAB 12.5mg 10 28.72
TAB 25mg 10 49.24
CARVIL     Zydus
cadila
TAB 12.5mg 10 29.00
TAB 25mg 10 55.00
TAB 6.25mg 10 19.50
TAB 3.125mg 10 13.50
CARVIPRESS     Stancare
TAB 12.5mg   25.00
       




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Drug Information
  

   

   
Pharmacokinetics
 

After oral administration rapidly and extensively absorb. Metabolism is primarily hepatic.

Top
 

Indication & Dosage
 

Oral
HYPERTENSION:
Initially 6.25mg b.i.d. for 7-14 days, later increased to 12.5mg for 7-14 days if required. Max. daily dose 50mg
CONGESTIVE HEART FAILURE: Initially 3,125mg b.i.d for 2 weeks. If well tolerated increased to 6.25mg b.i.d, later increased at doublefold every two weeks as tolerated by the patient. Patients below 80kgs; Max. 25mg b.i.d; Patients above 80kgs: Max. 50mg b.i.d. Dose increase not to be done until symptoms of congestive heart failure or vasodilation stabilise.

Top
 

Action
 

Carvedilol, an arylethanolamine is a non specific adrenoreceptor antagonist with alpha- 1 blocking acitvity. It exerts antihypertensive effect partly by reducing total peripheral resistance and vasodilation, by blocking alpha-adrenoreceptor and partly by inhibiting beta-adrenoreceptor mediated compensatory mechanisms. the nonspecific action also avoid utoward effects associated with conventional beta blocker or vasodialator therapy, also suited for the management of patients with renal impairment, NIDDM or IDDM. Has no adverse effects on plasma lipid profiles.

 

Interactions
 

Antidiabetic agents: Effects of insulin and oral hypoglycaemics enhaced.
Calcium blockers: Isolated case of conduction disturbance have been observed.
Clonidine: Blood pressure and heart rate lowering effects potentiated.
Digoxin: Serum concentrations of digoxin are increased requiring monitoring of digoxin.
Rifampicin: Plasma concentration of carvedilol reduced by 70%.

Top
 

Adverse Effect & Precautions
 

Postural hyypotension, dizziness, headache, fatigue, GI disturbance, dry eyes.

Abrupt withdrawal. Initial treatment with low dose. Avoid driving or operating hazardous machinery. Patients with bronchospastic disease and elderly.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.

 Top
 

CARCA

 

Intas

TAB

12.5mg

10

26.00

CARDIVAS

 

 

Sun

TAB

12.5mg

10

99.00

CARVETREND

 

 

Nicholas

TAB

12.5mg

10

28.72

TAB

25mg

10

49.24

CARVIL

 

 

Zydus cadila

TAB

12.5mg

10

29.00

TAB

25mg

10

55.00

TAB

6.25mg

10

19.50

TAB

3.125mg

10

13.50

CARVIPRESS

 

 

Stancare

TAB

12.5mg

 

25.00

 

 

 

 

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By |2022-07-20T16:44:47+00:00July 20, 2022|Uncategorized|Comments Off on Carvedilol

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