Drug Information

 


   






   

Pharamcokinetics



Cefaclor is well absorbed from the gastrointestinal tract but plasma
concentrations are slightly lower than those achieved with cephalexin or
cephradine. Doses of 250, 500, and 1000 mg by mouth produce peak plasma
concentrations of about 6, 13, and 23 micrograms per mL respectively at
0.5 to 1 hour. The presence of food may delay the absorption of cefaclor,
but the total amount absorbed is unchanged. A plasma half-life of 0.5 to
1 hour has been reported; it may be slightly prolonged in patients with
renal impairment. About 25% is bound to plasma proteins.

Cefaclor appears to be widely distributed in the body; it crosses the
placenta and low concentrations have been detected in breast milk. It is
rapidly excreted by the kidneys; up to 85% of a dose appears unchanged
in the urine within 8 hours, the greater part within 2 hours. High
concentrations of cefaclor are achieved in the urine within 8 hours of a
dose; peak concentrations of 600, 900, and 1900 micrograms per mL have
been reported after doses of 250, 500, and 1000 mg respectively.
Probenecid delays excretion. Some cefaclor is removed by haemodialysis.

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Indication
& Dosage


 



Oral

RESPIRATORY TRACT INFECTIONS, OTITIS MEDIA, PHARYNGITIS, UTI,
INFECTIONS, UNCOMPLICATED GONOCOCCAL URETHRITIS:
Adults: 250-500mg every
8 hours. Children: 20mg/kg/day in divided doses every 8 hours. Otitis
media: 40mg/kg/day. Adult: Maximum daily dosage is 4g. Children: Maximum
daily dosage is 1g. Treatment for atleast 48 hours after patient becomes
asymptomatic. Renal impairment: No dose change required.

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Action

 


Bactericidal by inhibition of cell wall synthesis. Active against a
wide range of Gram-Postive and Gram-Negative organisms, uropathogens.
Unique feature is its aactivity against Haemophilus influenzae including
strains producing betalactamases. Not active against Pseudomonas,
Proteus and Enterococci.

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Interaction

 


Aminoglycosides (Gentamycin, Tobramycin)-Nephrotoxicity of
aminoglycosides potentiated.

Bacteriostatic agents like Chloramphenicol: Decrease efficacy of
Cefaclor.

Probenecid: Slows tubular excretion and this enhances efficacy 

Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of cefaclor.

Lab Test: Urine Glucose: False positive with Benedicts solution and
Fehlings solution.

Direct Coomb’s Test: False postive.

Urinary 17-ketosteroid values: Falsely elevated values.

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Adverse
Effect & Precaution

 


Nausea, epigastric distress, vomiting, diarrhoea, skin rash, urticaria,
transient hepatitis, eosinophilia and genital pruritus.



Pseudomembranous colitis, penicillin sensitive patients.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands
available in Market


 























DISTACLOR

Eli lilly Ranbary
CAPS 250mg 3 49.50
SYRUP

125mg/5ml


30ml


52.80
SYRUP 187mg/5ml 30ml 69.50
DISTACLOR CD

Eli Lilly Ranbary
TAB 375mg 2 51.40
KEFLOR

Ranbary
CAPS 250mg 10 169.80
SUSP 125mg/ml 30ml 52.45
SUSP 187mg/5ml 30ml 75.10
DROPS 50mg/ml 10ml 37.05
KEFLOR-MR

Ranbary
TAB 375mg 6 162.20
VERCEF

Stancare
CAPS 250mg

3
56.10
SUSP 125mg/5ml 30ml 52.45




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Drug Information
 

   

   
Pharamcokinetics

Cefaclor is well absorbed from the gastrointestinal tract but plasma concentrations are slightly lower than those achieved with cephalexin or cephradine. Doses of 250, 500, and 1000 mg by mouth produce peak plasma concentrations of about 6, 13, and 23 micrograms per mL respectively at 0.5 to 1 hour. The presence of food may delay the absorption of cefaclor, but the total amount absorbed is unchanged. A plasma half-life of 0.5 to 1 hour has been reported; it may be slightly prolonged in patients with renal impairment. About 25% is bound to plasma proteins.
Cefaclor appears to be widely distributed in the body; it crosses the placenta and low concentrations have been detected in breast milk. It is rapidly excreted by the kidneys; up to 85% of a dose appears unchanged in the urine within 8 hours, the greater part within 2 hours. High concentrations of cefaclor are achieved in the urine within 8 hours of a dose; peak concentrations of 600, 900, and 1900 micrograms per mL have been reported after doses of 250, 500, and 1000 mg respectively. Probenecid delays excretion. Some cefaclor is removed by haemodialysis.

Top
 

Indication & Dosage
 

Oral
RESPIRATORY TRACT INFECTIONS, OTITIS MEDIA, PHARYNGITIS, UTI, INFECTIONS, UNCOMPLICATED GONOCOCCAL URETHRITIS:
Adults: 250-500mg every 8 hours. Children: 20mg/kg/day in divided doses every 8 hours. Otitis media: 40mg/kg/day. Adult: Maximum daily dosage is 4g. Children: Maximum daily dosage is 1g. Treatment for atleast 48 hours after patient becomes asymptomatic. Renal impairment: No dose change required.

Top
 

Action
 

Bactericidal by inhibition of cell wall synthesis. Active against a wide range of Gram-Postive and Gram-Negative organisms, uropathogens. Unique feature is its aactivity against Haemophilus influenzae including strains producing betalactamases. Not active against Pseudomonas, Proteus and Enterococci.

Top
 

Interaction
 

Aminoglycosides (Gentamycin, Tobramycin)-Nephrotoxicity of aminoglycosides potentiated.
Bacteriostatic agents like Chloramphenicol: Decrease efficacy of Cefaclor.
Probenecid: Slows tubular excretion and this enhances efficacy 
Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of cefaclor.
Lab Test: Urine Glucose: False positive with Benedicts solution and Fehlings solution.
Direct Coomb’s Test: False postive.
Urinary 17-ketosteroid values: Falsely elevated values.

Top
 

Adverse Effect & Precaution
 

Nausea, epigastric distress, vomiting, diarrhoea, skin rash, urticaria, transient hepatitis, eosinophilia and genital pruritus.

Pseudomembranous colitis, penicillin sensitive patients.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.

Top
 

DISTACLOR

Eli lilly Ranbary

CAPS

250mg

3

49.50

SYRUP

125mg/5ml

30ml

52.80

SYRUP

187mg/5ml

30ml

69.50

DISTACLOR CD

Eli Lilly Ranbary

TAB

375mg

2

51.40

KEFLOR

Ranbary

CAPS

250mg

10

169.80

SUSP

125mg/ml

30ml

52.45

SUSP

187mg/5ml

30ml

75.10

DROPS

50mg/ml

10ml

37.05

KEFLOR-MR

Ranbary

TAB

375mg

6

162.20

VERCEF

Stancare

CAPS

250mg

3

56.10

SUSP

125mg/5ml

30ml

52.45

Top
 

                                                                                                   

 

By |2022-07-20T16:44:48+00:00July 20, 2022|Uncategorized|Comments Off on Cefaclor

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