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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations
Adverse Effect
& Precautions |
Brands available in Market
Pharmacokinetics
After oral administration Cefixime is absorbed from G.I. tract and is
widely distributed in most tissues and fluids. High concentration of the
drug is attained in bile. Nearly 50% of the absorbed Cefixime is
excreted unchanged in urine in 24 hours.
Oral
OTITIS MEDIA, PHARYNGITIS, TONSILLITIS, ACUTE BRONCHITIS, ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS, UTI: Adult: 200-400mg/day as a single dose or in 2 divided doses. Children: 8mg/kg/day as a single dose or in 2 divided doses. Children under 6 months: Not recommended. Treatment continued for 48 hours after disappearance of symptoms. Some dose reduction in renal impairment.
UNCOMPLICATED GONORRHEA: 400mg single dose.
Action
Bactericidal to many Gram-Postive and Gram-Negative pathogens.
Susceptible organisms include betalactamase-producing strains also. Not
active against Pseudomonas, Group D Streptococci, Listeria,
monocytogenes, many strains of Staphylococci, Bacteroides fragilis and
clostridia
Probenecid: Increases and prolongs the effect.
Oral anticoagulant: Effect of anticoagulants potentiated.
Adverse
Effect & Precaution
Diarrhoea, nausea, vomiting, dyspepsia, abdominal pain, skin rash,
urticaria, durg fever, pruritus, dizziness, headache
Penicillin sensitive patients, severe renal impairment. Safety in
children aged less than 6 months has not been established.
Pregnancy: Use with caution
Breast Feeding: Safety not established.
Man: Use with caution.
