Drug Information

 



    






   

Pharmacokinetics

 


After oral administration Cefixime is absorbed from G.I. tract and is
widely distributed in most tissues and fluids. High concentration of the
drug is attained in bile. Nearly 50% of the absorbed Cefixime is
excreted unchanged in urine in 24 hours.

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Indication
& Dosage


 



Oral

OTITIS MEDIA, PHARYNGITIS, TONSILLITIS, ACUTE BRONCHITIS, ACUTE
EXACERBATIONS OF CHRONIC BRONCHITIS, UTI:
Adult: 200-400mg/day as a
single dose or in 2 divided doses. Children: 8mg/kg/day as a single dose
or in 2 divided doses. Children under 6 months: Not recommended.
Treatment continued for 48 hours after disappearance of symptoms. Some
dose reduction in renal impairment.

UNCOMPLICATED GONORRHEA: 400mg single dose.

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Action

 


Bactericidal to many Gram-Postive and Gram-Negative pathogens.
Susceptible organisms include betalactamase-producing strains also. Not
active against Pseudomonas, Group D Streptococci, Listeria,
monocytogenes, many strains of Staphylococci, Bacteroides fragilis and
clostridia

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Interaction

 


Probenecid: Increases and prolongs the effect. 

Oral anticoagulant: Effect of anticoagulants potentiated.

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Adverse
Effect & Precaution


 


Diarrhoea, nausea, vomiting, dyspepsia, abdominal pain, skin rash,
urticaria, durg fever, pruritus, dizziness, headache



Penicillin sensitive patients, severe renal impairment. Safety in
children aged less than 6 months has not been established.

Pregnancy: Use with caution

Breast Feeding: Safety not established.

Man: Use with caution.

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CEFSPAN

Burroughs Wellcome
CAP 100MG 4 141.56
CEFTAS
Intas
TAB 200mg 4 180.00
TAB 100mg 10 250.00
TAB 400mg 4 352.00
ORFIX

Orchid
CAPS 100mg 4 88.00
CAPS 200mg 4 175.00
DIS TAB 100mg 4 88.00
TAXIM-O

Alkem
TAB 200mg 4 196.00
TAB 100mg 10 270.00
TOPCEF

Torrent
TAB 200mg 4 330.00
TAB 400mg 2 320.00





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Drug Information
 

    

   
Pharmacokinetics
 

After oral administration Cefixime is absorbed from G.I. tract and is widely distributed in most tissues and fluids. High concentration of the drug is attained in bile. Nearly 50% of the absorbed Cefixime is excreted unchanged in urine in 24 hours.

Top
  

Indication & Dosage
 

Oral
OTITIS MEDIA, PHARYNGITIS, TONSILLITIS, ACUTE BRONCHITIS, ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS, UTI:
Adult: 200-400mg/day as a single dose or in 2 divided doses. Children: 8mg/kg/day as a single dose or in 2 divided doses. Children under 6 months: Not recommended. Treatment continued for 48 hours after disappearance of symptoms. Some dose reduction in renal impairment.
UNCOMPLICATED GONORRHEA: 400mg single dose.

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Action
 

Bactericidal to many Gram-Postive and Gram-Negative pathogens. Susceptible organisms include betalactamase-producing strains also. Not active against Pseudomonas, Group D Streptococci, Listeria, monocytogenes, many strains of Staphylococci, Bacteroides fragilis and clostridia

Top
  

Interaction
 

Probenecid: Increases and prolongs the effect. 
Oral anticoagulant: Effect of anticoagulants potentiated.

Top
  

Adverse Effect & Precaution
 

Diarrhoea, nausea, vomiting, dyspepsia, abdominal pain, skin rash, urticaria, durg fever, pruritus, dizziness, headache

Penicillin sensitive patients, severe renal impairment. Safety in children aged less than 6 months has not been established.
Pregnancy: Use with caution
Breast Feeding: Safety not established.
Man: Use with caution.

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CEFSPAN

Burroughs Wellcome

CAP

100MG

4

141.56

CEFTAS

Intas

TAB

200mg

4

180.00

TAB

100mg

10

250.00

TAB

400mg

4

352.00

ORFIX

Orchid

CAPS

100mg

4

88.00

CAPS

200mg

4

175.00

DIS TAB

100mg

4

88.00

TAXIM-O

Alkem

TAB

200mg

4

196.00

TAB

100mg

10

270.00

TOPCEF

Torrent

TAB

200mg

4

330.00

TAB

400mg

2

320.00

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By |2022-07-20T16:41:17+00:00July 20, 2022|Uncategorized|Comments Off on Cefixime

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