Drug Information

 



    






  

Pharmacokinetics


 


Cefpodoxime proxetil is de-esterified in the intestinal epithelium
following oral administration, to release active cefpodoxime in the
bloodstream. Bioavailability is about 50% in fasting subjects and may be
increased in the presence of food. Absorption is decreased in conditions
of low gastric acidity. Plasma concentrations of about 1.5, 2.5, and 4.0
micrograms per mL have been achieved 2 to 3 hours after oral doses of
100, 200, and 400 mg cefpodoxime respectively. About 20 to 30% of
cefpodoxime is bound to plasma proteins. The plasma half-life is about 2
to 3 hours and is prolonged in patients with impaired renal function.

Cefpodoxime reaches therapeutic concentrations in the respiratory and
genito-urinary tracts and bile. It has been detected in low
concentrations in breast milk.

Cefpodoxime is excreted unchanged in the urine. It is removed by
dialysis.

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Indication & Dosage

  


Oral

MILD TO MODERATE INFECTIONS OF UPPER AND LOWER RESIPIRATORY TRACT
INFECTIONS NAMELY COMMUNITY ACQUIRED PNEUMONIA CAUSED BY S.PNEMONIAE,
H.INFLUENZAE (INCLUDING BETALACTAMASE PRODUCING STRAINS), ACUTE
BACTERIAL EXACERBATION OF CHRONIC BRONCHITIS CAUSED BY S. PNEUMONIAE,
H.INFLUENZAE(NON BETA LACTAMASE PRODUCING STAINS) OR M. CATERRAHALIS:

Adults and Children above 13 yeares: 20mg bid for 14 day. Max daily
dose: 400mg.

SEXUALLY TRANSMITTED DISEASES LIKE ACUTE AND UNCOMLICATED URETHRAL AND
CERVICAL GONORRHOEA CAUSED BY NIESSERIA GONORRHOEA (INCLUDING
PENICILLINASE PRODUCING STRAINS): Adults(13 years adn older): 200mg
single dose. SKIN AND SKIN STRUCTURE INFECTIONS CAUSED BY STAPH.AUREUS,
STEP.PYOGENS: Adults and Children above 13 years: 1100mg bid for 5-10
days. Max diily dose: 200mg

PHARYNGITIS AND TONSILITIS CAUSED BY STREP.PYOGENS: Adults (above 13
years): 400mg bid for 7-14 days. Max : 800mg daily. Children (5
months-12 years) : 5mg/kg/dose (Max: 100mg/dose) for 5-10 days. Max
daily dose: 200mg/day

UNCOMPLICATED URINARY TRACT INFECTIONS (CYSTITIS) CAUSED BY E.COLI,
K.PNEUMONIAE, P.MIRABILUS OR STAPH.SAPROTICUS: 100mg for 7 days. Max.
daily dose: 200mg.

ACUTE OTITIS MEDIA: Children(5 months-12 years): 10mmg/kg bid (Max:
200mg/dose) for 10 days. Max: 400mg/day.

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Action

 


Cefpodoxime proxetil is a produrg of the active metabolite
Cefpodoxime,which is formed by de-esterification of the prodrug in the
intestinal tract. Cefpodoxime is bactericidal and kills bacteria by
interfering with the synthesis of bacterial cell wall. The drug binds
with high affinity to penicillin binding protens(PBP), notably PBP1 AND
PBP2 in the bacterial cell wall and thus inhibits the transpeptidase
enzyme, an important moiety in the peptidoglycan synthesis which inturn
is responsible for the stability of the cell wall. It is found to be
active against community acquired upper an lower resipratory tract
pathogens including Streptococci, Pneumococci, Haemophyllus influenzae
and M.catarrahalis and some Enterobacteria. It is stable in the presence
of beta lactamase enzyme and hence effective against those organims
cephalosporins as well.

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Interactions

 


Absorption of cefpodoxime is decreased by concurrent ingestion of
antacids or histamine H(2)-receptor antagonists. Probenecid reduces the
renal excretion of cefpodoxime.

 




Adverse
Effect & Precaution




The most frequently reported adverse effects of cefpodoxime are
gastrointestinal disturbances, especially diarrhoea

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CEFOPROX

Cipla
TAB 100MG 6 129.00
TAB

200MG


6


252.00
DRY SYRUP 100MG/5ML 30ML 150.00
CEPODEM

Ranbaxy
FC TAB 100MG 6 115.00
FC TAB 200MG 6 225.00
SUSP 50MG/5ML 30ML 123.00




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Drug Information
 

    

  
Pharmacokinetics

 

Cefpodoxime proxetil is de-esterified in the intestinal epithelium following oral administration, to release active cefpodoxime in the bloodstream. Bioavailability is about 50% in fasting subjects and may be increased in the presence of food. Absorption is decreased in conditions of low gastric acidity. Plasma concentrations of about 1.5, 2.5, and 4.0 micrograms per mL have been achieved 2 to 3 hours after oral doses of 100, 200, and 400 mg cefpodoxime respectively. About 20 to 30% of cefpodoxime is bound to plasma proteins. The plasma half-life is about 2 to 3 hours and is prolonged in patients with impaired renal function.
Cefpodoxime reaches therapeutic concentrations in the respiratory and genito-urinary tracts and bile. It has been detected in low concentrations in breast milk.
Cefpodoxime is excreted unchanged in the urine. It is removed by dialysis.

Top
 

Indication & Dosage
  
Oral
MILD TO MODERATE INFECTIONS OF UPPER AND LOWER RESIPIRATORY TRACT INFECTIONS NAMELY COMMUNITY ACQUIRED PNEUMONIA CAUSED BY S.PNEMONIAE, H.INFLUENZAE (INCLUDING BETALACTAMASE PRODUCING STRAINS), ACUTE BACTERIAL EXACERBATION OF CHRONIC BRONCHITIS CAUSED BY S. PNEUMONIAE, H.INFLUENZAE(NON BETA LACTAMASE PRODUCING STAINS) OR M. CATERRAHALIS:
Adults and Children above 13 yeares: 20mg bid for 14 day. Max daily dose: 400mg.
SEXUALLY TRANSMITTED DISEASES LIKE ACUTE AND UNCOMLICATED URETHRAL AND CERVICAL GONORRHOEA CAUSED BY NIESSERIA GONORRHOEA (INCLUDING PENICILLINASE PRODUCING STRAINS): Adults(13 years adn older): 200mg single dose. SKIN AND SKIN STRUCTURE INFECTIONS CAUSED BY STAPH.AUREUS, STEP.PYOGENS: Adults and Children above 13 years: 1100mg bid for 5-10 days. Max diily dose: 200mg
PHARYNGITIS AND TONSILITIS CAUSED BY STREP.PYOGENS: Adults (above 13 years): 400mg bid for 7-14 days. Max : 800mg daily. Children (5 months-12 years) : 5mg/kg/dose (Max: 100mg/dose) for 5-10 days. Max daily dose: 200mg/day
UNCOMPLICATED URINARY TRACT INFECTIONS (CYSTITIS) CAUSED BY E.COLI, K.PNEUMONIAE, P.MIRABILUS OR STAPH.SAPROTICUS: 100mg for 7 days. Max. daily dose: 200mg.
ACUTE OTITIS MEDIA: Children(5 months-12 years): 10mmg/kg bid (Max: 200mg/dose) for 10 days. Max: 400mg/day.

Top
 

Action
 

Cefpodoxime proxetil is a produrg of the active metabolite Cefpodoxime,which is formed by de-esterification of the prodrug in the intestinal tract. Cefpodoxime is bactericidal and kills bacteria by interfering with the synthesis of bacterial cell wall. The drug binds with high affinity to penicillin binding protens(PBP), notably PBP1 AND PBP2 in the bacterial cell wall and thus inhibits the transpeptidase enzyme, an important moiety in the peptidoglycan synthesis which inturn is responsible for the stability of the cell wall. It is found to be active against community acquired upper an lower resipratory tract pathogens including Streptococci, Pneumococci, Haemophyllus influenzae and M.catarrahalis and some Enterobacteria. It is stable in the presence of beta lactamase enzyme and hence effective against those organims cephalosporins as well.

Top
 

Interactions
 

Absorption of cefpodoxime is decreased by concurrent ingestion of antacids or histamine H(2)-receptor antagonists. Probenecid reduces the renal excretion of cefpodoxime.

 

Adverse Effect & Precaution

The most frequently reported adverse effects of cefpodoxime are gastrointestinal disturbances, especially diarrhoea

Top
 

CEFOPROX

Cipla

TAB

100MG

6

129.00

TAB

200MG

6

252.00

DRY SYRUP

100MG/5ML

30ML

150.00

CEPODEM

Ranbaxy

FC TAB

100MG

6

115.00

FC TAB

200MG

6

225.00

SUSP

50MG/5ML

30ML

123.00

Top
 

                                               

 

By |2022-07-20T16:44:48+00:00July 20, 2022|Uncategorized|Comments Off on Cefoldixime Proxetil

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