Cefpodoxime proxetil is de-esterified in the intestinal epithelium following oral administration, to release active cefpodoxime in the bloodstream. Bioavailability is about 50% in fasting subjects and may be increased in the presence of food. Absorption is decreased in conditions of low gastric acidity. Plasma concentrations of about 1.5, 2.5, and 4.0 micrograms per mL have been achieved 2 to 3 hours after oral doses of 100, 200, and 400 mg cefpodoxime respectively. About 20 to 30% of cefpodoxime is bound to plasma proteins. The plasma half-life is about 2 to 3 hours and is prolonged in patients with impaired renal function.
Cefpodoxime reaches therapeutic concentrations in the respiratory and genito-urinary tracts and bile. It has been detected in low concentrations in breast milk.
Cefpodoxime is excreted unchanged in the urine. It is removed by dialysis.
MILD TO MODERATE INFECTIONS OF UPPER AND LOWER RESIPIRATORY TRACT INFECTIONS NAMELY COMMUNITY ACQUIRED PNEUMONIA CAUSED BY S.PNEMONIAE, H.INFLUENZAE (INCLUDING BETALACTAMASE PRODUCING STRAINS), ACUTE BACTERIAL EXACERBATION OF CHRONIC BRONCHITIS CAUSED BY S. PNEUMONIAE, H.INFLUENZAE(NON BETA LACTAMASE PRODUCING STAINS) OR M. CATERRAHALIS: Adults and Children above 13 yeares: 20mg bid for 14 day. Max daily dose: 400mg.
SEXUALLY TRANSMITTED DISEASES LIKE ACUTE AND UNCOMLICATED URETHRAL AND CERVICAL GONORRHOEA CAUSED BY NIESSERIA GONORRHOEA (INCLUDING PENICILLINASE PRODUCING STRAINS): Adults(13 years adn older): 200mg single dose. SKIN AND SKIN STRUCTURE INFECTIONS CAUSED BY STAPH.AUREUS, STEP.PYOGENS: Adults and Children above 13 years: 1100mg bid for 5-10 days. Max diily dose: 200mg
PHARYNGITIS AND TONSILITIS CAUSED BY STREP.PYOGENS: Adults (above 13 years): 400mg bid for 7-14 days. Max : 800mg daily. Children (5 months-12 years) : 5mg/kg/dose (Max: 100mg/dose) for 5-10 days. Max daily dose: 200mg/day
UNCOMPLICATED URINARY TRACT INFECTIONS (CYSTITIS) CAUSED BY E.COLI, K.PNEUMONIAE, P.MIRABILUS OR STAPH.SAPROTICUS: 100mg for 7 days. Max. daily dose: 200mg.
ACUTE OTITIS MEDIA: Children(5 months-12 years): 10mmg/kg bid (Max: 200mg/dose) for 10 days. Max: 400mg/day.
Cefpodoxime proxetil is a produrg of the active metabolite Cefpodoxime,which is formed by de-esterification of the prodrug in the intestinal tract. Cefpodoxime is bactericidal and kills bacteria by interfering with the synthesis of bacterial cell wall. The drug binds with high affinity to penicillin binding protens(PBP), notably PBP1 AND PBP2 in the bacterial cell wall and thus inhibits the transpeptidase enzyme, an important moiety in the peptidoglycan synthesis which inturn is responsible for the stability of the cell wall. It is found to be active against community acquired upper an lower resipratory tract pathogens including Streptococci, Pneumococci, Haemophyllus influenzae and M.catarrahalis and some Enterobacteria. It is stable in the presence of beta lactamase enzyme and hence effective against those organims cephalosporins as well.
Absorption of cefpodoxime is decreased by concurrent ingestion of antacids or histamine H(2)-receptor antagonists. Probenecid reduces the renal excretion of cefpodoxime.
Effect & Precaution
The most frequently reported adverse effects of cefpodoxime are gastrointestinal disturbances, especially diarrhoea