Drug Information

 



    






   

Pharmacokinetics




Cefotaxime is administered intraveneously or intramuscularly.Cefatoxime
is deacetylated in the body; the metabolite exerts weaker but
synergistic action with the parent drug.Its half life is 1 hour, but is
longer for the deacetylated metabolite hence permitting 12 hourly dose
in many situations.

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Indication
& Dosage



 


IM/IV

SEPTICAEMIA, BACTERAEMIA INFECTIONS IN IMMUNO-COMPROMISED PATIENSTS. RTI
INCLUDING PNEUMONIA, UTI, GYNAECOLOGICAL AND OBSTERTRICAL INFECTIONS
INCLUDING PELVIC CELLULITIS, AND ENDOMETRITIS. INTRAABDOMINAL INFECTIONS
INCLUDING PERITONITIS, MENINGITIS AND VENTRICULITIS, GONORRHOEA,
INFECTIONS WITH MULT-RESISTANT PATHOGENS:
Adult and children over 12
years: upto 12g/day in divided doses every 6,8 or 12 hours. Daily dose
max: 12g. Children 1 month-12 yrears: 50-100mg/kg/day in equally divided
doses every 6-12 hours. IN life-threatening infections upto
150-200mg/kg/day in equally divided doses every 6-12 hours. In
life-threatening infections upto 150-200mg/kg/day have been used.
Neonates upto 1 mont: 50mg/kg IV ever y12 hours during first week. IN
2-4 week neonates every 8 hours. 

SURGICAL PROPHYLAXIS: 1-2g before surgery. Repeated after 12 hours.

GONORRHOEA: A single does of 500mg IM.

Note: In renal impairment with creatinine clearance of 5mg/min or less,
cefotaxime dose is reducedd by 50% treatment is continued ofr upto 72
hours after relief of smptoms and for at least 10 days in Group A beta-haemolytic
streptococcal infections.

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Action

 


High activity against Gram-negative bacteria and a variety of
betalactamase-producing organisms. Active against pseudomonas and
anaerobic bacteria, and spirochetes. Can be combined with
aminoglycosides, metronidazole and fosfomycin.

Top

  




Interactions

Activity may
be enchanced by aminoglycosides.

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Adverse
Effect & Precaution




Skin rash, drug fever, anaphylaxis, nausea, vomiting, diarrhoea,
thrombocytopenia and leucopenia, Local reaciton and pain at injection
site. Pseudomembranous colits, headache.

Cross sensitivity
in penicillin hypersensitive patients has been reported.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be used.

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Brands available in Market
BESTAX

Biological E
INJ 250MG VIAL 27.46
INJ

500mg


VIAL


47.06
INJ 1g VIAL 86.58
BIOTAX

Biochem
INJ 250mg VIAL 27.52
INJ 500mg VIAL 47.16
INJ 1g VIAL 63.00
INJ 125mg VIAL 17.83
BLUCE-TM

Blue Cross
INJ 250mg VIAL 25.10
INJ 500mg VIAL 40.00
INJ 1g VIAL 84.70
C-TAX

Emcure
INJ 250mg VIAL 18.50
INJ 500mg VIAL 36.00
INJ 1g VIAL 65.00
INJ 125mg

VIAL
13.50
INJ 1.5G VIAL 85.00
CEFANTRAL

Lupin
INJ 250mg VIAL 25.13
INJ 500mg VIAL 49.44
INJ 1g VIAL 84.72
CEFATOX INJ

P & B Labs
INJ 250mg/vial 250mg 25.90
INJ 1g/vial 1g 87.31
CEFLIN

Lincoln
INJ 125mg vial 15.17
INJ 250mg vial 24.90
INJ 500mg vial 44.74
INJ 1g vial 85.95
INJ 500mg/vial VIAL 49.90
INJ 250mg/vial VIAL 27.25
INJ 125mg/vial VIAL 17.65
CEFTEX

Prem Pharma
INJ 250mg/vial 250mg 27.50
INJ 500mg/vial 500mg 47.15
INJ 1g/vial 1g 86.68
CLAFORAN

Roussel
INJ 250mg VIAL 25.13
INJ 1g VIAL 84.72
DESATAX

Plethico
INJ 250mg VIAL 0.00
INJ 500mg VIAL 0.00
INJ 1g VIAL 0.00
EVACEF

Neon Labs
INJ 250mg vial 26.47
INJ 1g vial 82.09
FAXIM

Chemech
INJ 250mg VIAL 28.50
INJ 1g VIAL 79.00
GRAMOTAX

Brown & Burk
INJ 250mg VIAL 25.40
INJ 1g VIAL 82.60
HALTAX

Hindustan Antibiotic
INJ 250mg VIAL 26.50
INJ 500mg VIAL 49.43
INJ 1g VIAL 98.00
LYFORAN

Lyka
INJ 250mg VIAL 25.13
INJ 1g VIAL 84.70
NEPOTAX

TTK
INJ 250mg VIAL 27.65
INJ 1g VIAL 93.20
NILSTAT

Uni Sankyo
INJ 250mg VIAL 27.24
INJ 125mg VIAL 17.64
INJ 500mg VIAL 46.67
INJ 1g VIAL 85.86
NUTAXIN

Aglowmed
INJ 250mg VIAL 27.69
INJ 1g VIAL 87.28
INJ 125mg VIAL 17.93
INJ 500mg VIAL 47.44
OMINAX

Mapra
INJ 125mg vial 16.70
INJ 250mg vial 24.23
INJ 500mg vial 46.43
INJ 1g vial 84.10
OMNATAX

Hoechst Marion Roussel
INJ 250mg VIAL 25.13
INJ 1g VIAL 84.72
OMNICEF

Aristo
INJ 250mg VIAL 26.94
INJ 500mg VIAL 46.16
INJ 1g VIAL 83.96
INJ 125mg VIAL 17.45
ORITAXIM

Alidac
INJ 250mg VIAL 31.00
INJ 500mg VIAL 60.00
INJ 1g VIAL 110.00
TAX-O-BID

Orchid
INJ 125mg vial 16.13
INJ 250mg vial 24.21
INJ 500mg vial 44.38
INJ 1g vial 80.70
TAXCEF

J.K.Ind
INJ 250mg VIAL 25.07
INJ 500mg VIAL 46.49
TAXIM

Alkerm
INJ 250mg VIAL 24.32
INJ 1g VIAL 81.63
INJ 125mg VIAL 17.25
INJ 500mg VIAL 44.09
INJ 2g VIAL 159.14
TROYCEF

Troikaa
INJ 250mg/vial 1VIAL 25.13
INJ 1g/vial 1VIAL 84.72





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Drug Information
 

    

   
Pharmacokinetics


Cefotaxime is administered intraveneously or intramuscularly.Cefatoxime is deacetylated in the body; the metabolite exerts weaker but synergistic action with the parent drug.Its half life is 1 hour, but is longer for the deacetylated metabolite hence permitting 12 hourly dose in many situations.

Top
  

Indication & Dosage
 
IM/IV
SEPTICAEMIA, BACTERAEMIA INFECTIONS IN IMMUNO-COMPROMISED PATIENSTS. RTI INCLUDING PNEUMONIA, UTI, GYNAECOLOGICAL AND OBSTERTRICAL INFECTIONS INCLUDING PELVIC CELLULITIS, AND ENDOMETRITIS. INTRAABDOMINAL INFECTIONS INCLUDING PERITONITIS, MENINGITIS AND VENTRICULITIS, GONORRHOEA, INFECTIONS WITH MULT-RESISTANT PATHOGENS:
Adult and children over 12 years: upto 12g/day in divided doses every 6,8 or 12 hours. Daily dose max: 12g. Children 1 month-12 yrears: 50-100mg/kg/day in equally divided doses every 6-12 hours. IN life-threatening infections upto 150-200mg/kg/day in equally divided doses every 6-12 hours. In life-threatening infections upto 150-200mg/kg/day have been used. Neonates upto 1 mont: 50mg/kg IV ever y12 hours during first week. IN 2-4 week neonates every 8 hours. 
SURGICAL PROPHYLAXIS: 1-2g before surgery. Repeated after 12 hours.
GONORRHOEA: A single does of 500mg IM.
Note: In renal impairment with creatinine clearance of 5mg/min or less, cefotaxime dose is reducedd by 50% treatment is continued ofr upto 72 hours after relief of smptoms and for at least 10 days in Group A beta-haemolytic streptococcal infections.

Top
  

Action
 

High activity against Gram-negative bacteria and a variety of betalactamase-producing organisms. Active against pseudomonas and anaerobic bacteria, and spirochetes. Can be combined with aminoglycosides, metronidazole and fosfomycin.

Top
  

Interactions

Activity may be enchanced by aminoglycosides.

Top
  

Adverse Effect & Precaution

Skin rash, drug fever, anaphylaxis, nausea, vomiting, diarrhoea, thrombocytopenia and leucopenia, Local reaciton and pain at injection site. Pseudomembranous colits, headache.

Cross sensitivity in penicillin hypersensitive patients has been reported.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be used.

Top
  

BESTAX

Biological E

INJ

250MG

VIAL

27.46

INJ

500mg

VIAL

47.06

INJ

1g

VIAL

86.58

BIOTAX

Biochem

INJ

250mg

VIAL

27.52

INJ

500mg

VIAL

47.16

INJ

1g

VIAL

63.00

INJ

125mg

VIAL

17.83

BLUCE-TM

Blue Cross

INJ

250mg

VIAL

25.10

INJ

500mg

VIAL

40.00

INJ

1g

VIAL

84.70

C-TAX

Emcure

INJ

250mg

VIAL

18.50

INJ

500mg

VIAL

36.00

INJ

1g

VIAL

65.00

INJ

125mg

VIAL

13.50

INJ

1.5G

VIAL

85.00

CEFANTRAL

Lupin

INJ

250mg

VIAL

25.13

INJ

500mg

VIAL

49.44

INJ

1g

VIAL

84.72

CEFATOX INJ

P & B Labs

INJ

250mg/vial

250mg

25.90

INJ

1g/vial

1g

87.31

CEFLIN

Lincoln

INJ

125mg

vial

15.17

INJ

250mg

vial

24.90

INJ

500mg

vial

44.74

INJ

1g

vial

85.95

INJ

500mg/vial

VIAL

49.90

INJ

250mg/vial

VIAL

27.25

INJ

125mg/vial

VIAL

17.65

CEFTEX

Prem Pharma

INJ

250mg/vial

250mg

27.50

INJ

500mg/vial

500mg

47.15

INJ

1g/vial

1g

86.68

CLAFORAN

Roussel

INJ

250mg

VIAL

25.13

INJ

1g

VIAL

84.72

DESATAX

Plethico

INJ

250mg

VIAL

0.00

INJ

500mg

VIAL

0.00

INJ

1g

VIAL

0.00

EVACEF

Neon Labs

INJ

250mg

vial

26.47

INJ

1g

vial

82.09

FAXIM

Chemech

INJ

250mg

VIAL

28.50

INJ

1g

VIAL

79.00

GRAMOTAX

Brown & Burk

INJ

250mg

VIAL

25.40

INJ

1g

VIAL

82.60

HALTAX

Hindustan Antibiotic

INJ

250mg

VIAL

26.50

INJ

500mg

VIAL

49.43

INJ

1g

VIAL

98.00

LYFORAN

Lyka

INJ

250mg

VIAL

25.13

INJ

1g

VIAL

84.70

NEPOTAX

TTK

INJ

250mg

VIAL

27.65

INJ

1g

VIAL

93.20

NILSTAT

Uni Sankyo

INJ

250mg

VIAL

27.24

INJ

125mg

VIAL

17.64

INJ

500mg

VIAL

46.67

INJ

1g

VIAL

85.86

NUTAXIN

Aglowmed

INJ

250mg

VIAL

27.69

INJ

1g

VIAL

87.28

INJ

125mg

VIAL

17.93

INJ

500mg

VIAL

47.44

OMINAX

Mapra

INJ

125mg

vial

16.70

INJ

250mg

vial

24.23

INJ

500mg

vial

46.43

INJ

1g

vial

84.10

OMNATAX

Hoechst Marion Roussel

INJ

250mg

VIAL

25.13

INJ

1g

VIAL

84.72

OMNICEF

Aristo

INJ

250mg

VIAL

26.94

INJ

500mg

VIAL

46.16

INJ

1g

VIAL

83.96

INJ

125mg

VIAL

17.45

ORITAXIM

Alidac

INJ

250mg

VIAL

31.00

INJ

500mg

VIAL

60.00

INJ

1g

VIAL

110.00

TAX-O-BID

Orchid

INJ

125mg

vial

16.13

INJ

250mg

vial

24.21

INJ

500mg

vial

44.38

INJ

1g

vial

80.70

TAXCEF

J.K.Ind

INJ

250mg

VIAL

25.07

INJ

500mg

VIAL

46.49

TAXIM

Alkerm

INJ

250mg

VIAL

24.32

INJ

1g

VIAL

81.63

INJ

125mg

VIAL

17.25

INJ

500mg

VIAL

44.09

INJ

2g

VIAL

159.14

TROYCEF

Troikaa

INJ

250mg/vial

1VIAL

25.13

INJ

1g/vial

1VIAL

84.72

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By |2022-07-20T16:44:49+00:00July 20, 2022|Uncategorized|Comments Off on Cefotaxime

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