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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions
Adverse
Effect & Precautions |
Brands available in Market
Ceftazidime is given only parenterally and it penetrates tissues well. Renal tubular blocking with probenicid is reduced in renal insufficiency. Its concentration in the bile is similar to that of plasma. Its excretion is reduced in renal impairment. It is metabolised in the liver and gets excreted via the kidneys.
Indication & Dosage
SEVERE INFECTIONS: SEPTICAEMIA, BACTERAEMIA, PERITONITIS, MENINGIITS,
INFECTIONS IN IMMUNO-COMPROMISED PATIENTS WITH HAEMATOLOGICAL OR SOLID
MALIGNANCIES: 2g IV every 8-12 hrs. LOWER RESPIRATORY TRACT
INFECTIONS: PNEUMONIA, PLEURISY, LUNG ABSCESS, BRONCHIECTASIS, LUNG
INFECTIONS IN PATIENTS WITH CYSTIC FIBROSIS: 1-2G iv EVERY 8-12 hrs.
SEVERE OTITIS MEDIA, SINUSITIS MASTOIDITIS: 1-2G IV every 8-12 hrs. UTI
SUCH AS PYELONEPHRITIS: 1-2G iv EVERY 8-12 hrs.
SKIN AND SOFT TISSUE INFECTIONS: 1-2g IV every 8-12 hrs. GI TRACT
INFECTIONS: BONE AND JOINT INFECTIONS: 1-2G iv every 8-12 hrs.
NOTE: In acutely ill elderly max daily dose should be 3g per day.
Children and infants: 30-100mg/kg/day in 2-3 divided doses. Neonates:
25-60mg/kg/day in 2 divided doses. In neonatal meningitis upto
150mg/kg/day has been given in divided doses. Renal insufficiency: Dose
modified according to creatinine clearance.
Extended spectrum of activity against Gram-negative bacteria especially pseudomonas. Highly stable to betalactamases. Synergises with aminoglycosides.
Ceftazidime
gives false positive Coombs test and false positive test for urine
sugar.
Skin rash, urticaria, neutropenia, thrombocytopenia, neutropenia, thrombocytopenia, pain at injection site pseudomembranous colitis, diarrohoea, fever, headache, dizziness, phlebitis, rise in liver enzymes and blood urea
Precautions to
be taken in acutely ill elderly patients.
Pregnancy: Use with caution
Breast Feeding: Use with caution.
Man: Use with caution.
