Drug Information

 



    






Pharmacokinetics

 

Ceftriaxone demonstrates nonlinear dose-dependent pharmacokinetics
because of its protein binding; about 85 to 95% is bound to plasma
protein depending on the plasma concentration of ceftriaxone.

Mean peak plasma concentrations of about 40 and 80 micrograms per mL
have been reported 2 hours after intramuscular injection of 0.5 and 1 g
of ceftriaxone respectively. The plasma half-life of ceftriaxone is not
dependent on the dose and varies between 6 and 9 hours; it may be
prolonged in neonates. The half-life does not change appreciably in
patients with moderate renal impairment, but it may be prolonged in
severe renal impairment especially when there is also hepatic
impairment.

Ceftriaxone is widely distributed in body tissues and fluids. It crosses
both inflamed and non-inflamed meninges, generally achieving therapeutic
concentrations in the CSF. It crosses the placenta and low
concentrations have been detected in breast milk. High concentrations
are achieved in bile.

About 40 to 65% of a dose of ceftriaxone is excreted unchanged in the
urine, principally by glomerular filtration; the remainder is excreted
in the bile and is ultimately found in the faeces as unchanged drug and
microbiologically inactive compounds.

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Indication
& Dosage


 


IV

LIFE-THREATENING INFECTIONS; BACTERAEMIA; SEPTICAEMIA: 
Adults:
1-2g once a day. Total daily dose not more than 4g. Chidlren:
50-70mg/kg/day once or in 2 divided doses. Total daily dose not to
exceed 2g.

MENINGITIS: 100mg/kg/day upto max of 4g/day in divided doses every 12
hours.

No dose changes needed in hepatic or renal impairment.

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Action

 



Action against most Gram-positive and Gram-negative organisms and
some anaerobes. Pseudomonas sppp. show variable sussceptibility. Stable
against betalactamases.

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Interactions

 


Ceftriaxone has an N-methylthiotriazine side-chain and may have the
potential to increase the effects of anticoagulants and to cause a
disulfiram-like reaction with alcohol, as may cephalosporins with the
related N-methylthiotetrazole side chain.

Unlike many cephalosporins, probenecid does not affect the renal
excretion of ceftriaxone.


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Adverse
Effect & Precautions


 

Skin rash, urticaria,
trasient rise in liver enzymes & reversible neutropenia.



Neonates hepatic disease and severe biliary obstruction

Pregnancy: Use with caution

Breast Feeding: Use with caution.

Man: May be used.

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Brands
available in Market


 























































































BECEF

Alkem
INJ 250mg VIAL 51.00
INJ

500mg


VIAL


90.00
INJ 1g VIAL 165.00
C-TRI

Emcure
INJ 250mg 1VIAL 33.00
INJ

500mg
1VIAL 55.00
INJ 1g 1VIAL 99.00
CEFAXONE IM

Lupin
(Ceftriaxone as sod. 250,500 & 1000mg+amp
of 1% Lignocaine with each


INJ 250mg VIAL 53.38
INJ

500mg
VIAL 106.76
INJ 1g VIAL 213.52
CEFERA

Plethico
INJ 500mg VIAL 0.00
INJ 200 VIAL 0.00
INJ 1g VIAL 0.00
CEFOGRAM

Orchid
INJ 250mg VIAL 40.35
INJ

500mg
VIAL 68.59
INJ 1g VIAL 140.21
CEFTRAX

Dee-Pharma
INJ 250mg VIAL 45.00
INJ

1g
VIAL 125.00
INJ 125mg VIAL 29.50
CETRIAX

Karantaka Antibiotics
INJ 250mg VIAL 40.00
INJ 1g VIAL 168.00
GRAMOEF

Micro Labs
INJ 250MG VIAL 32.00
INJ 1G VIAL 98.00
GUTENCEF

Merck
(With 5ml sterile water for inj )


INJ 250mg VIAL 45.00
INJ 1g VIAL 50.00
INOCEF

J.K.Ind.
INJ 250mg VIAL 52.60
INJ 1g VIAL 211.30
LYCEFT

Lyka
INJ 250mg VIAL 48.00
INJ 1g VIAL 190.00
MONOCEF I.V.

Aristo
INJ 250mg VIAL 44.64
INJ 1g VIAL 123.28
INJ 125mg VIAL 29.76
INJ 500mg VIAL 74.39
INJ 2g VIAL 236.40
MONOTAX

Biochem
INJ 250mg vial 45.27
INJ 1g vial 125.77
INJ 500mg vial 75.46
NOSOCEF

Merind
INJ 250mg VIAL 50.00
INJ 1g VIAL 132.50
OFRAMAX

Ranbaxy
INJ 250mg VIAL 53.00
INJ 1g VIAL 214.00
INJ 500mg VIAL 80.00
POWERCEF

Wockhardt
(WIth water for inj & disposable syringe
& needle


INJ 125mg VIAL 35.00
INJ 250mg VIAL 49.00
INJ 500mg VIAL 89.00
INJ 1g VIAL 66.00
TOROCEF

Torrent
INJ 250mg VIAL 52.90
INJ 1g VIAL 225.00
TRAXOL

Cachet Pharma
INJ 125mg 1VIAL 30.00
INJ 250mg 1VIAL 45.00
INJ 500mg 1VIAL 75.00
INJ 1g 1VIAL 125.00
TRIAX

Prem Pharma
INJ 250mg/via VIAL 45.00
INJ 1g/via VIAL 130.00
TRIXON

Lincoln
INJ 250mg/via VIAL 42.90
INJ 500mg/via VIAL 99.00
INJ 125mg/vial VIAL 29.90
INJ 1g/vial VIAL 167.90
ZEFONE

Cadila Healthcare
INJ 250mg VIAL 39.72
INJ 1g VIAL 123.75




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  Drug Information
 

    

Pharmacokinetics
 
Ceftriaxone demonstrates nonlinear dose-dependent pharmacokinetics because of its protein binding; about 85 to 95% is bound to plasma protein depending on the plasma concentration of ceftriaxone.
Mean peak plasma concentrations of about 40 and 80 micrograms per mL have been reported 2 hours after intramuscular injection of 0.5 and 1 g of ceftriaxone respectively. The plasma half-life of ceftriaxone is not dependent on the dose and varies between 6 and 9 hours; it may be prolonged in neonates. The half-life does not change appreciably in patients with moderate renal impairment, but it may be prolonged in severe renal impairment especially when there is also hepatic impairment.
Ceftriaxone is widely distributed in body tissues and fluids. It crosses both inflamed and non-inflamed meninges, generally achieving therapeutic concentrations in the CSF. It crosses the placenta and low concentrations have been detected in breast milk. High concentrations are achieved in bile.
About 40 to 65% of a dose of ceftriaxone is excreted unchanged in the urine, principally by glomerular filtration; the remainder is excreted in the bile and is ultimately found in the faeces as unchanged drug and microbiologically inactive compounds.

TOP
 

Indication & Dosage
 
IV
LIFE-THREATENING INFECTIONS; BACTERAEMIA; SEPTICAEMIA: 
Adults: 1-2g once a day. Total daily dose not more than 4g. Chidlren: 50-70mg/kg/day once or in 2 divided doses. Total daily dose not to exceed 2g.
MENINGITIS: 100mg/kg/day upto max of 4g/day in divided doses every 12 hours.
No dose changes needed in hepatic or renal impairment.

TOP
 

Action
 

Action against most Gram-positive and Gram-negative organisms and some anaerobes. Pseudomonas sppp. show variable sussceptibility. Stable against betalactamases.

TOP
 

Interactions
 
Ceftriaxone has an N-methylthiotriazine side-chain and may have the potential to increase the effects of anticoagulants and to cause a disulfiram-like reaction with alcohol, as may cephalosporins with the related N-methylthiotetrazole side chain.
Unlike many cephalosporins, probenecid does not affect the renal excretion of ceftriaxone.

TOP
 

Adverse Effect & Precautions
 
Skin rash, urticaria, trasient rise in liver enzymes & reversible neutropenia.

Neonates hepatic disease and severe biliary obstruction
Pregnancy: Use with caution
Breast Feeding: Use with caution.
Man: May be used.

TOP
 

BECEF

Alkem

INJ

250mg

VIAL

51.00

INJ

500mg

VIAL

90.00

INJ

1g

VIAL

165.00

C-TRI

Emcure

INJ

250mg

1VIAL

33.00

INJ

500mg

1VIAL

55.00

INJ

1g

1VIAL

99.00

CEFAXONE IM

Lupin

(Ceftriaxone as sod. 250,500 & 1000mg+amp of 1% Lignocaine with each

INJ

250mg

VIAL

53.38

INJ

500mg

VIAL

106.76

INJ

1g

VIAL

213.52

CEFERA

Plethico

INJ

500mg

VIAL

0.00

INJ

200

VIAL

0.00

INJ

1g

VIAL

0.00

CEFOGRAM

Orchid

INJ

250mg

VIAL

40.35

INJ

500mg

VIAL

68.59

INJ

1g

VIAL

140.21

CEFTRAX

Dee-Pharma

INJ

250mg

VIAL

45.00

INJ

1g

VIAL

125.00

INJ

125mg

VIAL

29.50

CETRIAX

Karantaka Antibiotics

INJ

250mg

VIAL

40.00

INJ

1g

VIAL

168.00

GRAMOEF

Micro Labs

INJ

250MG

VIAL

32.00

INJ

1G

VIAL

98.00

GUTENCEF

Merck

(With 5ml sterile water for inj )

INJ

250mg

VIAL

45.00

INJ

1g

VIAL

50.00

INOCEF

J.K.Ind.

INJ

250mg

VIAL

52.60

INJ

1g

VIAL

211.30

LYCEFT

Lyka

INJ

250mg

VIAL

48.00

INJ

1g

VIAL

190.00

MONOCEF I.V.

Aristo

INJ

250mg

VIAL

44.64

INJ

1g

VIAL

123.28

INJ

125mg

VIAL

29.76

INJ

500mg

VIAL

74.39

INJ

2g

VIAL

236.40

MONOTAX

Biochem

INJ

250mg

vial

45.27

INJ

1g

vial

125.77

INJ

500mg

vial

75.46

NOSOCEF

Merind

INJ

250mg

VIAL

50.00

INJ

1g

VIAL

132.50

OFRAMAX

Ranbaxy

INJ

250mg

VIAL

53.00

INJ

1g

VIAL

214.00

INJ

500mg

VIAL

80.00

POWERCEF

Wockhardt

(WIth water for inj & disposable syringe & needle

INJ

125mg

VIAL

35.00

INJ

250mg

VIAL

49.00

INJ

500mg

VIAL

89.00

INJ

1g

VIAL

66.00

TOROCEF

Torrent

INJ

250mg

VIAL

52.90

INJ

1g

VIAL

225.00

TRAXOL

Cachet Pharma

INJ

125mg

1VIAL

30.00

INJ

250mg

1VIAL

45.00

INJ

500mg

1VIAL

75.00

INJ

1g

1VIAL

125.00

TRIAX

Prem Pharma

INJ

250mg/via

VIAL

45.00

INJ

1g/via

VIAL

130.00

TRIXON

Lincoln

INJ

250mg/via

VIAL

42.90

INJ

500mg/via

VIAL

99.00

INJ

125mg/vial

VIAL

29.90

INJ

1g/vial

VIAL

167.90

ZEFONE

Cadila Healthcare

INJ

250mg

VIAL

39.72

INJ

1g

VIAL

123.75

TOP
 

 

 

By |2022-07-20T16:44:49+00:00July 20, 2022|Uncategorized|Comments Off on Ceftriaxone Sodium

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