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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interaction
Adverse
Effect & Precautions |
Brands available in Market
Cephalexin is partially protein bound, attains high concentration in bile and is excreted in urine as such.Plasma half life is 60 minutes.
Oral
RESPIRATORY TRACT INFECTIONS, SINUSTITIS, OTITIS, SKIN AND SOFT TISSUE
INFECTIONS, GENITO-URINARY INFECTION INCLUDE ACUTE PROSTATITIS BILIARY
TRACT INFECTIONS, UTI: Adults: 1-2g/day in divided doses given 6 or
8 hourly. In severe infection upto 4g/day. Strep.Pharyngitis 500mg b.i.d.
for 7-14 days. Children: 25-50mg/kg/day doubled in severe infections. 2
or 4 divided doses. Otitis media: 75-100mg/kg/day in divided doses.
PROPHYLAXIS FOR BACTERIAL ENDOCARDITIS DURING SURGERY: 1gm before
incision followed by 500mg 4-8 hours later.
GONORRHEA: 2-3g along with Probenecid 0.5-1g as a single dose.
Action
Active against Strep.Pneumoniae, Neisseria meningtitdis,
N.gonorrhoeae and Staphylococci, Strep.Viridans. Less active against
penicillinase-producing Staphylococci.
Adverse
Effect & Precaution
Skin rash, urticaria, nausea,
vomiting, diarrhoea and neutropenia.
Special precaution to be taken in patients who are hypersensitive to
penicillins, pseudomembranous collitis, pregnancy, lactation and renal
failure.
Pregnancy: May be used.
Breast Feeding: Use with caution.
Man: May be used.
DROPS