Drug Information

  



    






Pharmacokinetics

 


After oral administration it shows reliable and adequate abosorption. It
is almost completely metabolised.

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Indication
& Dosage


 


Oral

HODGKIN’S DISEASE: Given as part of multidrug regimen at 6mg/m2 (max
12mg) orally for 10-14 days in each cycle for 6 or more cycles.

NONHODGKIS’S LYMPHOMA: Options are,(1) Continours therapy: 2mg/daily (2)
10mg daily for 6 weeks on cycles. (3) 25mg daily for 4 days each month
for 6 months.

CHRONIC LYMPHOCYTIC LEUKEMIA: Start at 0.1mg/kg/day. When leucocyte
count fallls to 10,000 mm3, interrupt for weeks and restart as required.

ADVANCED OVARIAN CANCER: 0.2mg/kg/day for 4-6 weeks.

BREAST CANCER: 0.1-0.2mg/day.

VALDENSTROM’S MACROGLOULINAEMIA: 6-12mg daily until leukopenia occurs.
Then 2-8mg daily.

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Action

 


Chlorambucil arrests cell cycle at the G2 (premitotic) stage. It
crosses cross-linking of the cellular DNA strands. DNA breaks down and
cell dies.

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Interaction

 


Other Myelosuppressive Agents: Efficacy of these enhaced.

Phenlebutazone & Warfarin: Potentiate the efficacy of chlorambucil

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Adverse Effect
& Precaution


 


Nausea, vomiting, epigastric discomfort, pulmonary fibrosis, dermatitis,
seizures, hypatotoxicity, amenorrhoea, azoospermia, bone marrow
depression. Peripheral neuropathy.



Precaution: Carcinogenic potential, altered fertility haematological
monitoring, extravasation, hyperuricaemia, pprphyria

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be used..

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Brands
available in Market


 




LEUKERAN   Burroughs Wellcome






TAB 2mg 25 129.43
TAB 5mg 25 141.69




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Drug Information
  

    

Pharmacokinetics
 

After oral administration it shows reliable and adequate abosorption. It is almost completely metabolised.

TOP
  

Indication & Dosage
 

Oral
HODGKIN’S DISEASE: Given as part of multidrug regimen at 6mg/m2 (max 12mg) orally for 10-14 days in each cycle for 6 or more cycles.
NONHODGKIS’S LYMPHOMA: Options are,(1) Continours therapy: 2mg/daily (2) 10mg daily for 6 weeks on cycles. (3) 25mg daily for 4 days each month for 6 months.
CHRONIC LYMPHOCYTIC LEUKEMIA: Start at 0.1mg/kg/day. When leucocyte count fallls to 10,000 mm3, interrupt for weeks and restart as required.
ADVANCED OVARIAN CANCER: 0.2mg/kg/day for 4-6 weeks.
BREAST CANCER: 0.1-0.2mg/day.
VALDENSTROM’S MACROGLOULINAEMIA: 6-12mg daily until leukopenia occurs. Then 2-8mg daily.

TOP
  

Action
 

Chlorambucil arrests cell cycle at the G2 (premitotic) stage. It crosses cross-linking of the cellular DNA strands. DNA breaks down and cell dies.

TOP
  

Interaction
 

Other Myelosuppressive Agents: Efficacy of these enhaced.
Phenlebutazone & Warfarin: Potentiate the efficacy of chlorambucil

TOP
  

Adverse Effect & Precaution
 

Nausea, vomiting, epigastric discomfort, pulmonary fibrosis, dermatitis, seizures, hypatotoxicity, amenorrhoea, azoospermia, bone marrow depression. Peripheral neuropathy.

Precaution: Carcinogenic potential, altered fertility haematological monitoring, extravasation, hyperuricaemia, pprphyria
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be used..

TOP
  

LEUKERAN

 

Burroughs Wellcome

TAB

2mg

25

129.43

TAB

5mg

25

141.69

TOP
 

 

 

By |2022-07-20T16:44:45+00:00July 20, 2022|Uncategorized|Comments Off on Chlorambucil

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