Drug Information

 



    






Pharmacokinetics

 


Absorption of chlordiazepoxide is almost complete after oral
administration. Absorption after intramuscular injection may be slow and
erratic depending on the site of injection. Chlordiazepoxide is
extensively bound (about 96%) to plasma proteins. Reported values for
the elimination half-life of chlordiazepoxide have ranged from about 5
to 30 hours, but its main active metabolite desmethyldiazepam has a
half-life of several days. Other pharmacologically active metabolites of
chlordiazepoxide include desmethylchlordiazepoxide, demoxepam, and
oxazepam. Chlordiazepoxide passes into the CSF and breast milk, and
crosses the placenta. Unchanged drug and metabolites are excreted in the
urine, mainly as conjugated metabolites.

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Indication
& dosage


  

Oral

ANIETY STATES, PHOBIAS, PSYCHOSOMATIC DISORDERS: Adults: 20-40mg
daily. Severe cases upto 50-100mg/day. Children 5-10mg daily.

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Action

 


Increases activity of the inhibitory transmitter GABA in different
parts of CNS. Some muscle relaxant and anticonvulsant activity.

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Interaction

 


Alcohol & other CNS Depressants: Enhanced CNS effects.

Aminophylline: Antagonize the sedative effect.

Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid,
Ketoconazole, Metoprolol, Propoxyphene, Propranolol,

Valproic acid: Elimination of chloradiazepoxide decreased due to
inhibitionof hepatic metabolism leading to enhanced activity.

Digoxin: Increase in serum concentration of Digoxin.

Imipramine & Desipramine: Enhanced activity of these drugs

Levodopa: decrease in antiparkinsonim efficacy.

Morphine, Pethidine, Atropine  and Magnesium trisilicate:
Absorption of chloridazepoxide is impaired.

Probenecid: May causerapid onset or prolonged effect.

Rifampcin: Decreases efficacy.

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Adverse
Effect & Precaution


 


Nausea, headache, vertigo, skin rash, light headedness.



Precaution: Hepatic or renal dysfunction.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be given in reduced dose.

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EQUILIBRIUM

Jagsonpal
TAB 10mg 10 9.94
LIBRIUM

Piramal Healthcare
TAB 10mg 10 6.00
TAB 25mg 10 9.47





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Drug Information
 

    

Pharmacokinetics
 

Absorption of chlordiazepoxide is almost complete after oral administration. Absorption after intramuscular injection may be slow and erratic depending on the site of injection. Chlordiazepoxide is extensively bound (about 96%) to plasma proteins. Reported values for the elimination half-life of chlordiazepoxide have ranged from about 5 to 30 hours, but its main active metabolite desmethyldiazepam has a half-life of several days. Other pharmacologically active metabolites of chlordiazepoxide include desmethylchlordiazepoxide, demoxepam, and oxazepam. Chlordiazepoxide passes into the CSF and breast milk, and crosses the placenta. Unchanged drug and metabolites are excreted in the urine, mainly as conjugated metabolites.

TOP
  

Indication & dosage
  
Oral
ANIETY STATES, PHOBIAS, PSYCHOSOMATIC DISORDERS: Adults: 20-40mg daily. Severe cases upto 50-100mg/day. Children 5-10mg daily.

TOP
  

Action
 

Increases activity of the inhibitory transmitter GABA in different parts of CNS. Some muscle relaxant and anticonvulsant activity.

TOP
  

Interaction
 

Alcohol & other CNS Depressants: Enhanced CNS effects.
Aminophylline: Antagonize the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol,
Valproic acid: Elimination of chloradiazepoxide decreased due to inhibitionof hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs
Levodopa: decrease in antiparkinsonim efficacy.
Morphine, Pethidine, Atropine  and Magnesium trisilicate: Absorption of chloridazepoxide is impaired.
Probenecid: May causerapid onset or prolonged effect.
Rifampcin: Decreases efficacy.

TOP
  

Adverse Effect & Precaution
 

Nausea, headache, vertigo, skin rash, light headedness.

Precaution: Hepatic or renal dysfunction.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be given in reduced dose.

TOP
  

EQUILIBRIUM

Jagsonpal

TAB

10mg

10

9.94

LIBRIUM

Piramal Healthcare

TAB

10mg

10

6.00

TAB

25mg

10

9.47

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By |2022-07-20T16:44:45+00:00July 20, 2022|Uncategorized|Comments Off on Chlordiazepoxide

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