Drug Information

 



    






Pharmacokinetics

 


After oral administration rapidly absorbed, it has long plasma half life
and is excreted slowly by kidney.

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Indication
& Dosage


 


NON-INSULIN-DEPENDENT DIABETES MELLITUS: Start with 200 or 125mg
daily especially in patients with lean body mass and increase dose upto
500mg daily. Elderly: Start low doses. Children: Not indicated.

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Action

 


Chlorpropamide stimulates insulin release from islet cells in
patients with NIDDM in response to glucose stimulus ti increases release
of antidiuretic hormone from pituitary and facilitates its action at the
renal tubules.

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Interaction

 


Chlorpropamide may produce profound facial flushing in association with
alcohol ingestion.

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Adverse
Effect & Precaution


 


Nausea, vomiting, cholestatic jaundice, skin rash, anaemia, leucopenia,
inappropriate secretion of antidiuretic hormone. Hypoglycaemia.

Precaution: Respiratory or cardiac failure, pancreatitory or cardiac
failure, pancreatitis, ischaemic vascular disease.

Pregnancy: Contraindicated.

Breast Feeding: Discontinue nursing or drug.

Man: Use with caution.

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Brands available in Market

DIABINESE

Pfizer
TAB 250mg 10 2.72





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Drug Information
 

    

Pharmacokinetics
 

After oral administration rapidly absorbed, it has long plasma half life and is excreted slowly by kidney.

Top
  

Indication & Dosage
 

NON-INSULIN-DEPENDENT DIABETES MELLITUS: Start with 200 or 125mg daily especially in patients with lean body mass and increase dose upto 500mg daily. Elderly: Start low doses. Children: Not indicated.

Top
  

Action
 

Chlorpropamide stimulates insulin release from islet cells in patients with NIDDM in response to glucose stimulus ti increases release of antidiuretic hormone from pituitary and facilitates its action at the renal tubules.

Top
  

Interaction
 

Chlorpropamide may produce profound facial flushing in association with alcohol ingestion.

Top
  

Adverse Effect & Precaution
 

Nausea, vomiting, cholestatic jaundice, skin rash, anaemia, leucopenia, inappropriate secretion of antidiuretic hormone. Hypoglycaemia.
Precaution: Respiratory or cardiac failure, pancreatitory or cardiac failure, pancreatitis, ischaemic vascular disease.
Pregnancy: Contraindicated.
Breast Feeding: Discontinue nursing or drug.
Man: Use with caution.

Top
  

DIABINESE

Pfizer

TAB

250mg

10

2.72

Top
 

 

 

By |2022-07-20T16:42:52+00:00July 20, 2022|Uncategorized|Comments Off on Chlorpropamide

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