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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions
Precautions |
Brands available in Market
Pharmacokinetics
Cinnarizine is absorbed from the gastrointestinal tract, peak plasma
concentrations occurring 2 to 4 hours after oral administration. It
undergoes metabolism and has a half-life of 3 to 6 hours. Cinnarizine is
excreted in the faeces mainly as unchanged drug, and in the urine
predominantly as metabolites.
Indication
& Dosage
Oral
VERTIGO AND OTHER VESTIBULAR DISTUBANCES, VOMITING IN MENIERE’S
DISEASE: Adults: 25-50mg t.i.d. Children: Half this dose t.i.d.
MOTION SICKNESS: 12.5-25mg 2 hrs before travel.
Action
Cinnarizine has calcium channel blocking activity selective for
arterial smooth muscle. It has some antihistamine activity. Cinnarizine
acts as a labyrinthine sedative. It also improves microcirculation by
reducing ischaemia-induced blood viscocity.
Alcohol & CNS depressants: action enhanced. Domperidone: enhances efficacy of cinnarizine.
Sedation, skin rash, drowsiness and G.I upset.
Precaution: Hypotension, while on therapy patients should not operate machinery or drive. To avoid alcohol
Pregnancy: Safety not established.
Breast Feeding: Use with caution.
Man: May be used.
