Drug Information

 



    







Pharmacokinetics


 


Cinnarizine is absorbed from the gastrointestinal tract, peak plasma
concentrations occurring 2 to 4 hours after oral administration. It
undergoes metabolism and has a half-life of 3 to 6 hours. Cinnarizine is
excreted in the faeces mainly as unchanged drug, and in the urine
predominantly as metabolites.

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Indication
& Dosage


 


Oral

VERTIGO AND OTHER VESTIBULAR DISTUBANCES, VOMITING IN MENIERE’S
DISEASE:
Adults: 25-50mg t.i.d. Children: Half this dose t.i.d. 

MOTION SICKNESS: 12.5-25mg 2 hrs before travel.




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Action

 


Cinnarizine has calcium channel blocking activity selective for
arterial smooth muscle. It has some antihistamine activity. Cinnarizine
acts as a labyrinthine sedative. It also improves microcirculation by
reducing ischaemia-induced blood viscocity.

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Interaction:



Alcohol & CNS depressants: action enhanced. Domperidone: enhances
efficacy of cinnarizine.

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Adverse
Effect & Precaution


 


Sedation, skin rash, drowsiness and G.I upset.



Precaution: Hypotension, while on therapy patients should not operate
machinery or drive. To avoid alcohol

Pregnancy: Safety not established.

Breast Feeding: Use with caution.

Man: May be used.

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PERIPHERAL VASODILATORS
CINTIGO

Wallace
TAB 25mg 10 12.00
F-TAB 75mg 10 19.00
CINZAIN

FDC
TAB 25mg 10 10.20
TAB 75mg 20 25.00
DIZIRON

Glenmark
TAB 25mg 10 12.50
F-TAB 75mg 10 29.50
STEDICIN

Morepen
TAB 25mg 10 9.90
TAB 75mg 10 16.90
STUGERON

Ethnor
TAB 25mg 25 42.90
F-TAB 75mg 20 84.00
VERTIGON

Geno
TAB 25mg 10 13.50
TAB 75mg 10 27.63



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Drug Information
 

    

Pharmacokinetics
 

Cinnarizine is absorbed from the gastrointestinal tract, peak plasma concentrations occurring 2 to 4 hours after oral administration. It undergoes metabolism and has a half-life of 3 to 6 hours. Cinnarizine is excreted in the faeces mainly as unchanged drug, and in the urine predominantly as metabolites.

TOP
  

Indication & Dosage
 

Oral
VERTIGO AND OTHER VESTIBULAR DISTUBANCES, VOMITING IN MENIERE’S DISEASE:
Adults: 25-50mg t.i.d. Children: Half this dose t.i.d. 
MOTION SICKNESS: 12.5-25mg 2 hrs before travel.


TOP
  

Action
 

Cinnarizine has calcium channel blocking activity selective for arterial smooth muscle. It has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscocity.

TOP
  

Interaction:

Alcohol & CNS depressants: action enhanced. Domperidone: enhances efficacy of cinnarizine.

TOP
  

Adverse Effect & Precaution
 

Sedation, skin rash, drowsiness and G.I upset.

Precaution: Hypotension, while on therapy patients should not operate machinery or drive. To avoid alcohol
Pregnancy: Safety not established.
Breast Feeding: Use with caution.
Man: May be used.

TOP
  

PERIPHERAL VASODILATORS

CINTIGO

Wallace

TAB

25mg

10

12.00

F-TAB

75mg

10

19.00

CINZAIN

FDC

TAB

25mg

10

10.20

TAB

75mg

20

25.00

DIZIRON

Glenmark

TAB

25mg

10

12.50

F-TAB

75mg

10

29.50

STEDICIN

Morepen

TAB

25mg

10

9.90

TAB

75mg

10

16.90

STUGERON

Ethnor

TAB

25mg

25

42.90

F-TAB

75mg

20

84.00

VERTIGON

Geno

TAB

25mg

10

13.50

TAB

75mg

10

27.63

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By |2022-07-20T16:44:44+00:00July 20, 2022|Uncategorized|Comments Off on Cinnarizine

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