Drug
Information



  



    






 

Pharmacokinetics



This drug is a part of the second Generation 4-Quinolones having higher
activity against many Gram Positive and Gram Negative, but not anaerobic
organisms. They are concentrated in the Macrophages and
Polymorphonuclear Neutrophils.They are concentrated also in urine,
kidney, prostatic tissue and achieve therapeutic levels in lungs and
bones as well. It is completely absorbed and is distributed throughout
the body, it has elimination half life of 3-11 hrs, and is excreted by
the kidney.

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INDICATION & DOSAGE


 


Oral

UTI: 250-500MG B.I.D. 

PROSTATITIS AND COMPLICATED 

UTI: 500mg 12 hourly.

LOWER RESPIRATORY TRACT INFECTIONS: 250mg-500mg 12 hourly. Sometimes
750mg 12 hourly may be given.

GYAECOLOGICAL INFECTIONS AND BACTERIAL DIARRHOEA: 500mg 12 hourly.

SKIN AND SOFT TISSUE, BONE AND joint infections: 500-750mg 12 hourly.

GONORRHOEA: 250-500mg single dose.

SURGICAL PROPHYLAXIS: 750mg 60-90 mins before procedure

IV

UTI: 100mg b.i.d by slow infusion RTI AND OTHER INFECTIONS: 200-400mg
b.i.d by slow infusion over 60mins. 

GONORRHOEA: 100mg slow infusion as single dose.

NOTE: Children : Not recommended by considered necessary, 5-10mg/kg per
day in 2 divided doses. Elderly: Dosage interval not less than 12 hrs.
renal impairment: Dose changes according creatinine clearance. Duration
of treatment: Generally 5-7 days. Continued for at least 3 days after
symptoms have subsided.

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Action

 


Bactericidal by inhibition of DNA supercoiling in the bacteria. One of
the most active fluroquinolones, its spectrum includes gram-negative
aerobic bacteria including Enterobacteriaceae, Haemophilus, Neisseriae,
and Pseudomonas aeruginosa. It is also active in vitro, against many
Gram-Positive aerobic pathogens including penicilinase-producing, and
methicillin-resistant staphylococci.

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Interactions

 

With : Aminophylline, Oxtriphylline, Theophylline – ciprofloxacin may
increase the chance of adverse effects of these drugs. Antacids,
aluminum-, calcium-, or magnesium-containing, Iron supplements or
Sucralfate : These may keep any of the fluoroquinolones from being
effective. Caffeine : ciprofloxacin may increase the risk of adverse
effects of caffeine. Didanosine : Didanosine may reduce the
effectiveness of the fluoroquinolones. Warfarin : Ciprofloxacin may
potentiate the effects of warfarin, increasing the risk of bleeding
diathesis.

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Adverse
Effect & Precaution




Nausea, epigastric distress,
headache, vomiting, diarrhoea, restlessness, abdominal pain, skin rash,
insomnia, confusion, dizziness and arthralgia.


  


In Brain or spinal
cord disease, including arteriosclerosis of the blood vessels in the
brain or epilepsy or seizures: Fluoroquinolones may cause nervous system
side effects. Renal and hepatic impairment: Patients with renal disease
(alone) or renal disease and hepatic disease (together) may have an
increased chance of adverse effects.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.



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Brands
available in market
ABACT

Sarabhai
TAB 250MG 10 34.28
TAB 500MG 10 66.43
INJ-IV 200MG 100ML 41.40
TAB 750MG 4 40.29
ALCIPRO

Alkem
TAB 250mg 10 30.00
TAB 500mg 10 50.00
TAB 750mg 10 70.00
INJ-IV 2mg/ml 100ml 17.77
BAYCIP

Bayer
TAB 250mg 10 44.80
TAB 500mg 10 86.98
TAB 750mg 2 24.80
BAYCIP-URO

Bayer
TAB 100mg 6 12.96
BEKAYCIN

Boehringer Mannheim
TAB 250mg 10 40.00
TAB 500mg 10 70.00
BICIPRO

Kee Pharma
TAB 250MG 10 35.00
TAB 500MG 10 59.50
BIOCIP

Biochem
TAB 250mg 10 34.24
TAB 500mg 10 66.37
INJ-IV 2ng/ml 100ml 17.79
BIOCIP IV

Biochem
INJ-IV 400mg 200ml 34.24
C-FLOX

Prem Pharma
TAB 250mg 10 25.00
TAB 500mg 10 45.00
INJ-IV 20mg/10ml 100ml 45.00
CAREFLOX

Synthiko
TAB 250mg 10 50.00
TAB 500mg 10 75.00
CEBECT

Plethico
TAB 250mg 10 34.22
TAB 500mg 10 66.31
TAB 750mg 10 100.89
CEBRAN

Blue Cross
TAB 250mg 10 28.00
TAB 500mg 10 48.00
TAB 750mg 10 65.00
INJ-IV 200mg 100ml 31.95
CEEPRO

Lincoin
TAB 250mg 10 33.90
TAB 500mg 10 65.70
TAB 750mg 10 89.00
CFX

Remedies(india)
TAB 250mg 10 37.50
TAB 500mg 10 62.50
CIDAFLOX EYE/EAR

Juggat Pharma
DROPS 0.3% w/v 5ml 12.59
CIFOMED

Aglowmed
TAB 250mg 10 29.90
TAB 500mg 10 49.90
TAB 750mg 10 40.80
CIFRAN

Ranbaxy
INJ-IV 200mg 100ml 47.10
TAB 250mg 10 50.49
TAB 500mg 10 84.79
TAB 750mg 2 23.82
TAB 750mg 4 47.64
CIFRAN INFUSION

Ranbaxy
INF 100mg/50ml 50ml 30.00
INF 100mg/50ml 100ml 47.10
CIP

Helios
TAB 250mg 10 33.98
TAB 500mg 10 65.86
CIP AD

Albert David
TAB 250mg 10 44.00
TAB 500mg 10 78.00
INJ-IV 200mg 100ml 32.43
CIPIC

Biological E
TAB 250mg 10 34.51
TAB 500mg 10 66.56
CIPLOX

Cipla
TAB 250mg 10 44.00
TAB 500mg 10 78.90
TAB 750mg 10 114.50
INJ-IV 20mg/10ml 100ml 47.85
CIPORIC

Euphoric
TAB 250mg 10 34.21
TAB 500mg 10 59.00
CIPRIDE

Torrent
TAB 250mg 10 31.90
TAB 500mg 4 23.90
INJ-IV 200mg 100ml 39.00
CIPRIND

Indoco
TAB 250mg 10 30.30
TAB 500mg 10 60.02
CIPRO

Core
TAB 250mg 10 37.50
TAB 500mg 10 67.50
INJ-IV 200mg 10ml 35.00
CIPROACE

Ranbaxy
TAB 250mg 4 13.60
TAB 500mg 5 31.50
CIPROBACT

Combat Drugs
TAB 250mg 10 44.68
TAB 500mg 10 79.84
CIPROBID

Cadila Healthcare
TAB 250mg 10 34.45
TAB 500mg 10 66.77
TAB 750mg 2 20.32
INJ-IV 2mg/ml 100ml 17.77
INI-IV 2mg/ml 50ml 20.00
TAB 100mg 6 12.20
CIPROBIOTIC

Emcure
TAB 100mg 10 26.00
TAB 250mg 10 44.00
TAB 500mg 10 77.00
TAB 750mg 10 80.00
CIPROCAP

Pharmasynth
CAPS 500mg 4 27.60
CAPS 250mg

24.75
CIPROCORE

Core
TAB 250mg 20×10 470.00
TAB 500mg 20×10 850.00
CIPRODAC

Alidac
TAB 250mg 10 40.50
TAB 500mg 10 77.70
INJ-IV 2mg/ml 100ml 34.00
CIPRODEL

Citadel
TAB 250mg 10 36.00
TAB 500mg 10 69.00
CIPRODEX

Parenteral Drug
INF (Ciprofloxaxin(Lacate)

2mg+anhydrousdextrose 50mgml
200ml 55.00
CIPROGLEN

Glenmark
TAB 250mg 10 34.00
TAB 500mg 10 65.89
CIPROLET

DR.Reddy
TAB 250mg 10 25.20
TAB 500mg 10 39.96
INJ-IV 200mg/10ml 100ml 22.14
CIPROMYCETINE

Mac
TAB 500mg 10 47.25
CIPRONEX

Nestor
TAB 500mg 10 66.30
CIPRONEX 250

NESTOR
TAB 250mg 10 34.21
CIPROQUIN

Kramer
TAB 250mg 10 40.33
TAB 500mg 10 69.98

























INJ-IV 200mg/ml 100ml 33.29
CIPROSOL

SOL
TAB 250mg 10 41.30
TAB 500mg 10 29.20
INJ-IV 20mg/10ml 100ml 36.70
CIPROSTAR

Arivind Remedies
TAB 250mg 10 44.50
TAB 500mg 10 44.50
CIPROVA

Lupin
TAB 250mg 10 41.79
TAB 750mg 10 71.23
INJ-IV 2mg/ml 100ml 32.23
CIPROWIN

Alembic
TAB 250mg 10 34.40
TAB 500mg 10 66.67
TAB 750mg 10 99.96
INJ-IV 2mg/ml 100ml 17.86
CIPTAM

Sun Pharma
TAB 250mg 10×10 345.40
TAB 500mg 10×10 666.40
   




TOP

 

 






 

  

  
 
Drug Information
  

    

 
Pharmacokinetics

This drug is a part of the second Generation 4-Quinolones having higher activity against many Gram Positive and Gram Negative, but not anaerobic organisms. They are concentrated in the Macrophages and Polymorphonuclear Neutrophils.They are concentrated also in urine, kidney, prostatic tissue and achieve therapeutic levels in lungs and bones as well. It is completely absorbed and is distributed throughout the body, it has elimination half life of 3-11 hrs, and is excreted by the kidney.

TOP
  

INDICATION & DOSAGE
 

Oral
UTI: 250-500MG B.I.D. 
PROSTATITIS AND COMPLICATED 
UTI: 500mg 12 hourly.
LOWER RESPIRATORY TRACT INFECTIONS: 250mg-500mg 12 hourly. Sometimes 750mg 12 hourly may be given.
GYAECOLOGICAL INFECTIONS AND BACTERIAL DIARRHOEA: 500mg 12 hourly.
SKIN AND SOFT TISSUE, BONE AND joint infections: 500-750mg 12 hourly.
GONORRHOEA: 250-500mg single dose.
SURGICAL PROPHYLAXIS: 750mg 60-90 mins before procedure
IV
UTI: 100mg b.i.d by slow infusion RTI AND OTHER INFECTIONS: 200-400mg b.i.d by slow infusion over 60mins. 
GONORRHOEA: 100mg slow infusion as single dose.
NOTE: Children : Not recommended by considered necessary, 5-10mg/kg per day in 2 divided doses. Elderly: Dosage interval not less than 12 hrs. renal impairment: Dose changes according creatinine clearance. Duration of treatment: Generally 5-7 days. Continued for at least 3 days after symptoms have subsided.

TOP
  

Action
 

Bactericidal by inhibition of DNA supercoiling in the bacteria. One of the most active fluroquinolones, its spectrum includes gram-negative aerobic bacteria including Enterobacteriaceae, Haemophilus, Neisseriae, and Pseudomonas aeruginosa. It is also active in vitro, against many Gram-Positive aerobic pathogens including penicilinase-producing, and methicillin-resistant staphylococci.

TOP
  

Interactions
 
With : Aminophylline, Oxtriphylline, Theophylline – ciprofloxacin may increase the chance of adverse effects of these drugs. Antacids, aluminum-, calcium-, or magnesium-containing, Iron supplements or Sucralfate : These may keep any of the fluoroquinolones from being effective. Caffeine : ciprofloxacin may increase the risk of adverse effects of caffeine. Didanosine : Didanosine may reduce the effectiveness of the fluoroquinolones. Warfarin : Ciprofloxacin may potentiate the effects of warfarin, increasing the risk of bleeding diathesis.

TOP
  

Adverse Effect & Precaution

Nausea, epigastric distress, headache, vomiting, diarrhoea, restlessness, abdominal pain, skin rash, insomnia, confusion, dizziness and arthralgia.
  

In Brain or spinal cord disease, including arteriosclerosis of the blood vessels in the brain or epilepsy or seizures: Fluoroquinolones may cause nervous system side effects. Renal and hepatic impairment: Patients with renal disease (alone) or renal disease and hepatic disease (together) may have an increased chance of adverse effects.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.


TOP
  

ABACT

Sarabhai

TAB

250MG

10

34.28

TAB

500MG

10

66.43

INJ-IV

200MG

100ML

41.40

TAB

750MG

4

40.29

ALCIPRO

Alkem

TAB

250mg

10

30.00

TAB

500mg

10

50.00

TAB

750mg

10

70.00

INJ-IV

2mg/ml

100ml

17.77

BAYCIP

Bayer

TAB

250mg

10

44.80

TAB

500mg

10

86.98

TAB

750mg

2

24.80

BAYCIP-URO

Bayer

TAB

100mg

6

12.96

BEKAYCIN

Boehringer Mannheim

TAB

250mg

10

40.00

TAB

500mg

10

70.00

BICIPRO

Kee Pharma

TAB

250MG

10

35.00

TAB

500MG

10

59.50

BIOCIP

Biochem

TAB

250mg

10

34.24

TAB

500mg

10

66.37

INJ-IV

2ng/ml

100ml

17.79

BIOCIP IV

Biochem

INJ-IV

400mg

200ml

34.24

C-FLOX

Prem Pharma

TAB

250mg

10

25.00

TAB

500mg

10

45.00

INJ-IV

20mg/10ml

100ml

45.00

CAREFLOX

Synthiko

TAB

250mg

10

50.00

TAB

500mg

10

75.00

CEBECT

Plethico

TAB

250mg

10

34.22

TAB

500mg

10

66.31

TAB

750mg

10

100.89

CEBRAN

Blue Cross

TAB

250mg

10

28.00

TAB

500mg

10

48.00

TAB

750mg

10

65.00

INJ-IV

200mg

100ml

31.95

CEEPRO

Lincoin

TAB

250mg

10

33.90

TAB

500mg

10

65.70

TAB

750mg

10

89.00

CFX

Remedies(india)

TAB

250mg

10

37.50

TAB

500mg

10

62.50

CIDAFLOX EYE/EAR

Juggat Pharma

DROPS

0.3% w/v

5ml

12.59

CIFOMED

Aglowmed

TAB

250mg

10

29.90

TAB

500mg

10

49.90

TAB

750mg

10

40.80

CIFRAN

Ranbaxy

INJ-IV

200mg

100ml

47.10

TAB

250mg

10

50.49

TAB

500mg

10

84.79

TAB

750mg

2

23.82

TAB

750mg

4

47.64

CIFRAN INFUSION

Ranbaxy

INF

100mg/50ml

50ml

30.00

INF

100mg/50ml

100ml

47.10

CIP

Helios

TAB

250mg

10

33.98

TAB

500mg

10

65.86

CIP AD

Albert David

TAB

250mg

10

44.00

TAB

500mg

10

78.00

INJ-IV

200mg

100ml

32.43

CIPIC

Biological E

TAB

250mg

10

34.51

TAB

500mg

10

66.56

CIPLOX

Cipla

TAB

250mg

10

44.00

TAB

500mg

10

78.90

TAB

750mg

10

114.50

INJ-IV

20mg/10ml

100ml

47.85

CIPORIC

Euphoric

TAB

250mg

10

34.21

TAB

500mg

10

59.00

CIPRIDE

Torrent

TAB

250mg

10

31.90

TAB

500mg

4

23.90

INJ-IV

200mg

100ml

39.00

CIPRIND

Indoco

TAB

250mg

10

30.30

TAB

500mg

10

60.02

CIPRO

Core

TAB

250mg

10

37.50

TAB

500mg

10

67.50

INJ-IV

200mg

10ml

35.00

CIPROACE

Ranbaxy

TAB

250mg

4

13.60

TAB

500mg

5

31.50

CIPROBACT

Combat Drugs

TAB

250mg

10

44.68

TAB

500mg

10

79.84

CIPROBID

Cadila Healthcare

TAB

250mg

10

34.45

TAB

500mg

10

66.77

TAB

750mg

2

20.32

INJ-IV

2mg/ml

100ml

17.77

INI-IV

2mg/ml

50ml

20.00

TAB

100mg

6

12.20

CIPROBIOTIC

Emcure

TAB

100mg

10

26.00

TAB

250mg

10

44.00

TAB

500mg

10

77.00

TAB

750mg

10

80.00

CIPROCAP

Pharmasynth

CAPS

500mg

4

27.60

CAPS

250mg

24.75

CIPROCORE

Core

TAB

250mg

20×10

470.00

TAB

500mg

20×10

850.00

CIPRODAC

Alidac

TAB

250mg

10

40.50

TAB

500mg

10

77.70

INJ-IV

2mg/ml

100ml

34.00

CIPRODEL

Citadel

TAB

250mg

10

36.00

TAB

500mg

10

69.00

CIPRODEX

Parenteral Drug

INF

(Ciprofloxaxin(Lacate)
2mg+anhydrousdextrose 50mgml

200ml

55.00

CIPROGLEN

Glenmark

TAB

250mg

10

34.00

TAB

500mg

10

65.89

CIPROLET

DR.Reddy

TAB

250mg

10

25.20

TAB

500mg

10

39.96

INJ-IV

200mg/10ml

100ml

22.14

CIPROMYCETINE

Mac

TAB

500mg

10

47.25

CIPRONEX

Nestor

TAB

500mg

10

66.30

CIPRONEX 250

NESTOR

TAB

250mg

10

34.21

CIPROQUIN

Kramer

TAB

250mg

10

40.33

TAB

500mg

10

69.98

INJ-IV

200mg/ml

100ml

33.29

CIPROSOL

SOL

TAB

250mg

10

41.30

TAB

500mg

10

29.20

INJ-IV

20mg/10ml

100ml

36.70

CIPROSTAR

Arivind Remedies

TAB

250mg

10

44.50

TAB

500mg

10

44.50

CIPROVA

Lupin

TAB

250mg

10

41.79

TAB

750mg

10

71.23

INJ-IV

2mg/ml

100ml

32.23

CIPROWIN

Alembic

TAB

250mg

10

34.40

TAB

500mg

10

66.67

TAB

750mg

10

99.96

INJ-IV

2mg/ml

100ml

17.86

CIPTAM

Sun Pharma

TAB

250mg

10×10

345.40

TAB

500mg

10×10

666.40

 

 

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By |2022-07-20T16:43:34+00:00July 20, 2022|Uncategorized|Comments Off on Ciprofloxacin

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