Drug Information



  











Pharmacokinetics

 


Cisapride is readily absorbed from the gastrointestinal tract, with peak
plasma concentrations achieved 1 to 2 hours after a dose by mouth. It
undergoes extensive first-pass metabolism in the liver and gut wall,
resulting in an absolute bioavailability of 35 to 40%. The main
metabolic pathways are oxidative N-dealkylation, producing the major
metabolite norcisapride, and aromatic hydroxylation. More than 90% of a
dose is excreted as metabolites in the urine and faeces in approximately
equal amounts. A small amount is distributed into breast milk.

The elimination half-life has been reported to be about 10 hours.
Cisapride is about 98% bound to plasma proteins.

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Indication
& Dosage


 

Oral



IMPAIRED GASTRIC EMPTYING, NONULCER DYSPEPSIA, REFLUX OESOPHAGITIS,
CHRONIC CONSTIPATION: Adults:
5mg t.i.d may be increased upto 10mg q.i.d.
Infants and children: In persistent regurgitation 0.2mg/kg 3-4 times a
day 15 min before a fedd. Hepatic impairment: Starting dose is 2.5mg
t.i.d. and increased as required.

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Action

 


Increases gastro-intestinal motility throughout its length, by causin
gincreased release of acetylcholine frmo the myenteric plexuses in the
gut plain muscle. No dopamine receptor blocking effect. Increases lower
oesophageal sphicter pressure. Shortens gastric trasit time, refuces
oesophageal reflux and facilitates healing of oesophagela ulcers. No
effect on acid secretion. INcreases small intestine activity.

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Interactions

 


Cisapride is
metabolised by the isoenzyme cytochrome P450 3A4 (CYP3A4), and
concomitant administration with drugs which inhibit this enzyme is
contra-indicated because it may result in increased plasma
concentrations of cisapride, with QT interval prolongation and
ventricular arrhythmias. Such an interaction has been reported with
ketoconazole, and is possible with other azoles such as itraconazole and
miconazole as well as with the macrolides triacetyloleandomycin,
erythromycin, and clarithromycin, and with delavirdine or HIV-protease
inhibitors such as indinavir. Nefazodone may interact similarly.
Cisapride should not be used in patients receiving other medication
known to prolong the QT interval, including quinine or halofantrine,
terfenadine, astemizole, certain antiarrhythmics such as amiodarone or
quinidine, some antidepressants such as amitriptyline, phenothiazine
antipsychotics, and sertindole. Cimetidine may enhance cisapride
bioavailability.

Antimuscarinics and possibly opioid analgesics may antagonise the
gastrointestinal effects of cisapride. Because cisapride increases
intestinal motility it may affect the absorption of other drugs, either
diminishing absorption from the stomach or enhancing absorption from the
small intestine. Prothrombin times may be increased in some patients
receiving oral anticoagulants, and the effects of alcohol and some other
CNS depressants may be enhanced.

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Adverse
Effect & Precaution


 


Abdominal cramps, diarrhoea, rarely headache, convulsions,
extrapyramidal effects.



Precaution: Impaired hepatic or renal function.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man : may be used
.

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Brand
available in market




























































































ALIPRIDE

Centaur
TAB 10mg 10 33.16
CENZ

LA Pharma
TAB 10mg 10 35.00
CISACOL

Druga
TAB 10mg 10×10 380.00
CISADE

Unichem
TAB 10mg 10 33.75
SUSP 1mg/ml 30ml 14.60
CISALONE

Sigma
TAB 10mg 12×10 384.00
TAB 5mg 12×10 216.00
CISANORM

Gufic
TAB 10mg 10 39.90
CISAPID

Kopran
TAB 10mg 10 37.00
SUSP 1mg/ml 60ml 33.00
CISAPRO

Cadila Healthcare
TAB 10mg 10 36.96
SUSP 1mg/ml 30ml 18.62
TAB 5mg 10 19.83
CISATEN

Kamron
DISP-TABS 10mg 10 19.50
CISAWAL

Wallace
TAB 10mg 10 31.00
CISPEL

Panacea
LD-TAB 5mg 10 20.00
TAB 10mg 10 36.00
SUSP 1mg/ml 60ml 24.50
CIZA

Intas
TAB 10mg 10 36.10
SUSP 1mg/ml 30ml 15.50
SUSP 1mg/ml 60ml 29.40
CIZA-20

Intas
TAB 20mg 10 65.25
CIZAFAST

Core
TAB 10mg 20×10 490.00
ESORID

Sun Pharma
TAB 20mg 10 55.60
GASKIN

J.K.Ind
TAB 5mg 10 18.80
TAB 10mg 10 35.75
GASTRON

Inga
TAB 10mg 10 35.00
GASTROPEN

Morepen
DISP-TAB 5mg 10 15.00
TAB 10mg 10 26.00
TAB 20mg 10 44.90
MOTEN

Solus
TAB 10mg 10 38.55
SUSP 1mg/ml 60ml 33.00
MOTICARE

Intercare
TAB 10mg 10 33.00
MOTILAX

USV
TAB 10mg 10 37.22
SUSP 1mg/ml 30ml 22.95
NORMOCIS

Ind-Chemie
TAB 10mg 10 35.00
NUPRIDE

East India
TAB 10mg 10 34.06
PERISTIL

Dr Reddy’s
TAB 5mg 10 18.09
TAB 10mg 10 35.19
SUSP 1mg/ml 60ml 29.16
PREPULSID

Ethnor
TAB 5mg 10 25.72
TAB 10mg 10 38.00
TAB 20mg 10 68.90
PROCISA

Jenburkt
TAB 10mg 10 31.95
PROGIT

Bal Pharma
TAB 10mg 10 38.00
PROKINE

RPG
TAB 5mg 10 19.13
TAB 10mg 10 32.71
PRYDE

Aurobindo Pharma
TAB 10mg 10 31.00
PULSID

Max
TAB 5mg 10 16.00
TAB 10mg 10 29.50
SUSP 1mg/ml 60ml 29.80
RHONEPRIDE

Rhone-Plc
TAB 10mg 10 41.00
SYSPRIDE

Systopic
TAB 10mg 10 19.50
UNIPRIDE

Torrent
TAB 10mg 10 37.90




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Drug Information

  

Pharmacokinetics
 

Cisapride is readily absorbed from the gastrointestinal tract, with peak plasma concentrations achieved 1 to 2 hours after a dose by mouth. It undergoes extensive first-pass metabolism in the liver and gut wall, resulting in an absolute bioavailability of 35 to 40%. The main metabolic pathways are oxidative N-dealkylation, producing the major metabolite norcisapride, and aromatic hydroxylation. More than 90% of a dose is excreted as metabolites in the urine and faeces in approximately equal amounts. A small amount is distributed into breast milk.
The elimination half-life has been reported to be about 10 hours. Cisapride is about 98% bound to plasma proteins.

TOP
  

Indication & Dosage
 
Oral

IMPAIRED GASTRIC EMPTYING, NONULCER DYSPEPSIA, REFLUX OESOPHAGITIS, CHRONIC CONSTIPATION: Adults: 5mg t.i.d may be increased upto 10mg q.i.d. Infants and children: In persistent regurgitation 0.2mg/kg 3-4 times a day 15 min before a fedd. Hepatic impairment: Starting dose is 2.5mg t.i.d. and increased as required.

TOP
  

Action
 

Increases gastro-intestinal motility throughout its length, by causin gincreased release of acetylcholine frmo the myenteric plexuses in the gut plain muscle. No dopamine receptor blocking effect. Increases lower oesophageal sphicter pressure. Shortens gastric trasit time, refuces oesophageal reflux and facilitates healing of oesophagela ulcers. No effect on acid secretion. INcreases small intestine activity.

TOP
  

Interactions
 

Cisapride is metabolised by the isoenzyme cytochrome P450 3A4 (CYP3A4), and concomitant administration with drugs which inhibit this enzyme is contra-indicated because it may result in increased plasma concentrations of cisapride, with QT interval prolongation and ventricular arrhythmias. Such an interaction has been reported with ketoconazole, and is possible with other azoles such as itraconazole and miconazole as well as with the macrolides triacetyloleandomycin, erythromycin, and clarithromycin, and with delavirdine or HIV-protease inhibitors such as indinavir. Nefazodone may interact similarly. Cisapride should not be used in patients receiving other medication known to prolong the QT interval, including quinine or halofantrine, terfenadine, astemizole, certain antiarrhythmics such as amiodarone or quinidine, some antidepressants such as amitriptyline, phenothiazine antipsychotics, and sertindole. Cimetidine may enhance cisapride bioavailability.
Antimuscarinics and possibly opioid analgesics may antagonise the gastrointestinal effects of cisapride. Because cisapride increases intestinal motility it may affect the absorption of other drugs, either diminishing absorption from the stomach or enhancing absorption from the small intestine. Prothrombin times may be increased in some patients receiving oral anticoagulants, and the effects of alcohol and some other CNS depressants may be enhanced.

TOP
  

Adverse Effect & Precaution
 

Abdominal cramps, diarrhoea, rarely headache, convulsions, extrapyramidal effects.

Precaution: Impaired hepatic or renal function.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man : may be used
.

TOP
  

ALIPRIDE

Centaur

TAB

10mg

10

33.16

CENZ

LA Pharma

TAB

10mg

10

35.00

CISACOL

Druga

TAB

10mg

10×10

380.00

CISADE

Unichem

TAB

10mg

10

33.75

SUSP

1mg/ml

30ml

14.60

CISALONE

Sigma

TAB

10mg

12×10

384.00

TAB

5mg

12×10

216.00

CISANORM

Gufic

TAB

10mg

10

39.90

CISAPID

Kopran

TAB

10mg

10

37.00

SUSP

1mg/ml

60ml

33.00

CISAPRO

Cadila Healthcare

TAB

10mg

10

36.96

SUSP

1mg/ml

30ml

18.62

TAB

5mg

10

19.83

CISATEN

Kamron

DISP-TABS

10mg

10

19.50

CISAWAL

Wallace

TAB

10mg

10

31.00

CISPEL

Panacea

LD-TAB

5mg

10

20.00

TAB

10mg

10

36.00

SUSP

1mg/ml

60ml

24.50

CIZA

Intas

TAB

10mg

10

36.10

SUSP

1mg/ml

30ml

15.50

SUSP

1mg/ml

60ml

29.40

CIZA-20

Intas

TAB

20mg

10

65.25

CIZAFAST

Core

TAB

10mg

20×10

490.00

ESORID

Sun Pharma

TAB

20mg

10

55.60

GASKIN

J.K.Ind

TAB

5mg

10

18.80

TAB

10mg

10

35.75

GASTRON

Inga

TAB

10mg

10

35.00

GASTROPEN

Morepen

DISP-TAB

5mg

10

15.00

TAB

10mg

10

26.00

TAB

20mg

10

44.90

MOTEN

Solus

TAB

10mg

10

38.55

SUSP

1mg/ml

60ml

33.00

MOTICARE

Intercare

TAB

10mg

10

33.00

MOTILAX

USV

TAB

10mg

10

37.22

SUSP

1mg/ml

30ml

22.95

NORMOCIS

Ind-Chemie

TAB

10mg

10

35.00

NUPRIDE

East India

TAB

10mg

10

34.06

PERISTIL

Dr Reddy’s

TAB

5mg

10

18.09

TAB

10mg

10

35.19

SUSP

1mg/ml

60ml

29.16

PREPULSID

Ethnor

TAB

5mg

10

25.72

TAB

10mg

10

38.00

TAB

20mg

10

68.90

PROCISA

Jenburkt

TAB

10mg

10

31.95

PROGIT

Bal Pharma

TAB

10mg

10

38.00

PROKINE

RPG

TAB

5mg

10

19.13

TAB

10mg

10

32.71

PRYDE

Aurobindo Pharma

TAB

10mg

10

31.00

PULSID

Max

TAB

5mg

10

16.00

TAB

10mg

10

29.50

SUSP

1mg/ml

60ml

29.80

RHONEPRIDE

Rhone-Plc

TAB

10mg

10

41.00

SYSPRIDE

Systopic

TAB

10mg

10

19.50

UNIPRIDE

Torrent

TAB

10mg

10

37.90

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By |2022-07-20T16:44:46+00:00July 20, 2022|Uncategorized|Comments Off on Cisapride

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