Drug Information

 



        











 

Pharmacokinetics

 


After intravenous
administration cisplatin disappears from the plasma in a biphasic manner
and half-lives of 25 to 49 minutes and 58 to 73 hours have been reported
for total platinum. The majority of the platinum from a dose is rapidly
bound to plasma protein. Cisplatin is concentrated in the liver,
kidneys, and large and small intestines. Penetration into the central
nervous system appears to be poor. Excretion is mainly in the urine but
is incomplete and prolonged: up to about 50% of a dose has been reported
to be excreted in urine over 5 days, and platinum may be detected in
tissue for several months afterwards. Cisplatin is well-absorbed
following intraperitoneal administration.

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Indication
& Dosage


 


IV

METASTATIC OVARIAN AND TESTICULAR CANCERS, ADVANCED BLADDER CANCER,
CANCER OF HEAD AND NECK, CARCINOMA OF LUNG, SQUAMOUS CELL CARCINOMA OF
OESOPHAGUS:
Usually 50-120mg/m2 diluted with normal saline and given as
infusionover 30 minutes or 15-20mg/m2  for 5 days. This is given
once every 3-4weeks. Needles or infusion sets with aluminium part should
not be used for infusion of cisplatin. Repeat doses should not be given
util serum creatinine is below 1.5mg/100ml and BUN isbelow 25mg/100ml.
Vigorous hydration is essential for several hours before and after
cisplatin administraion with 2 or more litres o physiological saline
with 20mEq/L of kCL DURING EACH SESSION. In pre-existing renal
impairment cisplatin doses are reduced according to creatinine
clearance.Cisplatin is give to children and elders also at these general
dosage without any change.

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Action

 


Modifies cell cycle by interfering with DNA structure and fucntion.
Effectsare most prominent during the S phase but cells are killed at all
stages. Cisplatin synergises with other anticancer drugs such as
fluorouracil. Cisplatin has a narrow therapeutic margin and has high
toxicity.

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Interactions 

 


The concomitant use of other nephrotoxic or ototoxic drugs may
exacerbate the adverse effects of cisplatin. The effects of cisplatin on
renal function may also affect the pharmacokinetics of other drugs
excreted by the renal route.

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Adverse
Effect & Precaution




Nausea, vomiting, fever,
anaphylatic reaction, hypokalaemia, hypomagnesaemia, haemolysis, renal
damage, sterility, teratogenesis, ototoxicity, peripheral neuropathy,
Raynaud’s disease, bone marrow depression.



Precaution: Hypocalcaemia, hypomagnesaemia, monitor neurological status,
renal status and haematological function. Maintain hydration.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be given in reduced dose

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Brand
available in market


 













































































AQUAPLAT

Khandelwal
INJ 10mg/20ml vial 151.35
BLASTOLEM

Elder
INJ 10mg/v VIAL 125.00
INJ 50mg/v VIAL 511.98
CISPLAN

Natco
INJ 10mg/vial VIAL 94.54
INJ 50mg/vial VIAL 364.80
CISPLATIN

Biochem
INJ 10mg/10ml VIAL 80.00
INJ 50mg/50ml VIAL 300.00
CISPLATIN KOREA

Shree Ganesh
INJ 10mg 20ml 87.10
INJ 50mg 100ml 379.34
CISPLATINUM KOREA

Shree Ganesh
INJ 10mg 20ml 145.00
INJ 50mg/100ml 100ml 575.00
CYTOPLATIN 10

Cipla
INJ 10mg 20ml 80.00
CYTOPLATIN 50

Cipla
INJ 50mg 50ml 300.00
KEMOPLAT

Dabur
VIAL 10mg 20ml 77.00
VIAL 50mg 100ml 300.00
NEOPLAT

Biological E
INJ 10mg/20ml 20ml 80.10
INJ 50mg/100ml 100ml 295.00
ONCOPLATIN-AQ

T.D.P.L
INJ 10mg 20ml 86.90
INJ 50mg 100ml 324.50
PLATICARE

Criticare
INJ 1mg/ml 10ml 105.68
INJ 1mg/ml 50ml 367.38
PLATICIS

German Remedies
INJ 0.5mg/ml 20ml 86.70
INJ 1mg/ml 50ml 316.20
TEVAPLATIN

SPPL
INJ 10mg/vial VIAL 153.94
INJ 10mg/vial VIAL 554.17
TUMOTIN

Max
INJ 10mg/20ml 20ml 113.88
INJ 50mg/50ml 50ml 403.32
CYCOLXAN

Biochem
TAB 50mg 5×10 110.75
INJ 100mg VIAL 19.45
INJ 200mg VIAL 34.21
INJ 500mg VIAL 60.00
CYCRAM

VHB
INJ 100mg VIAL 20.50
INJ 200mg VIAL 29.50
INJ 500mg VIAL 60.00
INJ 500mg VIAL 110.00
ELDAMIDE

Elder
TAB 50mg 50 115.00
INJ 100mg VIAL 20.00
INJ 200mg VIAL 35.00
INJ 500mg VIAL 80.00
ENDOXAN

German Remedies
TAB 50mg 10 34.24
INJ 100mg VIAL 33.10
INJ 200mg VIAL 77.60
INJ 1gm VIAL 115.08
ENDOXAN-ASTA

German Remedies
TAB 50mg 10 34.90
INJ 100mg VIAL 33.80
INJ 200mg VIAL 72.20
INJ 1gm VIAL 117.40
LEDOXAN

Dabur
TAB 50mg 10 30.00
INJ 100mg 10ml 27.00
INJ 200mg 25ml 0.00
INJ 1gm 50ml 107.00




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Drug Information
 

        

 
Pharmacokinetics
 

After intravenous administration cisplatin disappears from the plasma in a biphasic manner and half-lives of 25 to 49 minutes and 58 to 73 hours have been reported for total platinum. The majority of the platinum from a dose is rapidly bound to plasma protein. Cisplatin is concentrated in the liver, kidneys, and large and small intestines. Penetration into the central nervous system appears to be poor. Excretion is mainly in the urine but is incomplete and prolonged: up to about 50% of a dose has been reported to be excreted in urine over 5 days, and platinum may be detected in tissue for several months afterwards. Cisplatin is well-absorbed following intraperitoneal administration.

TOP
  

Indication & Dosage
 

IV
METASTATIC OVARIAN AND TESTICULAR CANCERS, ADVANCED BLADDER CANCER, CANCER OF HEAD AND NECK, CARCINOMA OF LUNG, SQUAMOUS CELL CARCINOMA OF OESOPHAGUS:
Usually 50-120mg/m2 diluted with normal saline and given as infusionover 30 minutes or 15-20mg/m2  for 5 days. This is given once every 3-4weeks. Needles or infusion sets with aluminium part should not be used for infusion of cisplatin. Repeat doses should not be given util serum creatinine is below 1.5mg/100ml and BUN isbelow 25mg/100ml. Vigorous hydration is essential for several hours before and after cisplatin administraion with 2 or more litres o physiological saline with 20mEq/L of kCL DURING EACH SESSION. In pre-existing renal impairment cisplatin doses are reduced according to creatinine clearance.Cisplatin is give to children and elders also at these general dosage without any change.

TOP
  

Action
 

Modifies cell cycle by interfering with DNA structure and fucntion. Effectsare most prominent during the S phase but cells are killed at all stages. Cisplatin synergises with other anticancer drugs such as fluorouracil. Cisplatin has a narrow therapeutic margin and has high toxicity.

TOP
  

Interactions 
 

The concomitant use of other nephrotoxic or ototoxic drugs may exacerbate the adverse effects of cisplatin. The effects of cisplatin on renal function may also affect the pharmacokinetics of other drugs excreted by the renal route.

TOP
  

Adverse Effect & Precaution

Nausea, vomiting, fever, anaphylatic reaction, hypokalaemia, hypomagnesaemia, haemolysis, renal damage, sterility, teratogenesis, ototoxicity, peripheral neuropathy, Raynaud’s disease, bone marrow depression.

Precaution: Hypocalcaemia, hypomagnesaemia, monitor neurological status, renal status and haematological function. Maintain hydration.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be given in reduced dose

TOP
  

AQUAPLAT

Khandelwal

INJ

10mg/20ml

vial

151.35

BLASTOLEM

Elder

INJ

10mg/v

VIAL

125.00

INJ

50mg/v

VIAL

511.98

CISPLAN

Natco

INJ

10mg/vial

VIAL

94.54

INJ

50mg/vial

VIAL

364.80

CISPLATIN

Biochem

INJ

10mg/10ml

VIAL

80.00

INJ

50mg/50ml

VIAL

300.00

CISPLATIN KOREA

Shree Ganesh

INJ

10mg

20ml

87.10

INJ

50mg

100ml

379.34

CISPLATINUM KOREA

Shree Ganesh

INJ

10mg

20ml

145.00

INJ

50mg/100ml

100ml

575.00

CYTOPLATIN 10

Cipla

INJ

10mg

20ml

80.00

CYTOPLATIN 50

Cipla

INJ

50mg

50ml

300.00

KEMOPLAT

Dabur

VIAL

10mg

20ml

77.00

VIAL

50mg

100ml

300.00

NEOPLAT

Biological E

INJ

10mg/20ml

20ml

80.10

INJ

50mg/100ml

100ml

295.00

ONCOPLATIN-AQ

T.D.P.L

INJ

10mg

20ml

86.90

INJ

50mg

100ml

324.50

PLATICARE

Criticare

INJ

1mg/ml

10ml

105.68

INJ

1mg/ml

50ml

367.38

PLATICIS

German Remedies

INJ

0.5mg/ml

20ml

86.70

INJ

1mg/ml

50ml

316.20

TEVAPLATIN

SPPL

INJ

10mg/vial

VIAL

153.94

INJ

10mg/vial

VIAL

554.17

TUMOTIN

Max

INJ

10mg/20ml

20ml

113.88

INJ

50mg/50ml

50ml

403.32

CYCOLXAN

Biochem

TAB

50mg

5×10

110.75

INJ

100mg

VIAL

19.45

INJ

200mg

VIAL

34.21

INJ

500mg

VIAL

60.00

CYCRAM

VHB

INJ

100mg

VIAL

20.50

INJ

200mg

VIAL

29.50

INJ

500mg

VIAL

60.00

INJ

500mg

VIAL

110.00

ELDAMIDE

Elder

TAB

50mg

50

115.00

INJ

100mg

VIAL

20.00

INJ

200mg

VIAL

35.00

INJ

500mg

VIAL

80.00

ENDOXAN

German Remedies

TAB

50mg

10

34.24

INJ

100mg

VIAL

33.10

INJ

200mg

VIAL

77.60

INJ

1gm

VIAL

115.08

ENDOXAN-ASTA

German Remedies

TAB

50mg

10

34.90

INJ

100mg

VIAL

33.80

INJ

200mg

VIAL

72.20

INJ

1gm

VIAL

117.40

LEDOXAN

Dabur

TAB

50mg

10

30.00

INJ

100mg

10ml

27.00

INJ

200mg

25ml

0.00

INJ

1gm

50ml

107.00

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By |2022-07-20T16:44:44+00:00July 20, 2022|Uncategorized|Comments Off on Cisplatin

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