Drug
Information


   



     











Pharmacokinetics

Clarithromycin
is absorbed from small intestine, the drug gets partially destroyed by
the gastric juice so it must be administered in enteric coated form. It
is mainly concentrated in the bile.



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Indication
& Dosage


 



Oral

UPPER AND LOWER RTI SUCH AS PHARUNGITIS, SINUSITIS, BRONCHITIS,
PNEUMONIAS; SKIN INFECTIONS SUCH AS CELLULITIS, ERYSIPELAS: 250-500mg
b.i.d for  7-14 day. Children: 7.5mg/kg 12 hourly.

ATYPICAL MYCOBACTERIAL INFECTIONS: 500 b.i.d

ERADICATION OF H.PYLORI INFECTION: 1.0-1.5G daily in divided doses as
part of multidrug regimen.

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Action

 

Spectrum
of activity similar to that of erythromycin and includes most Gram-psitive
bacteria, Chlamydiae, some Gram-negative and Mycoplasma. The
14-hydroxymetabolite is also active and may act synergistically. SOme
atypical mycobacteria may also be susceptible. Pseudomonas and
enterbacteriaceae are not susceptible to clarithromycin.

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Interactions

 


With
Carbamazepine,Digoxin, Terfenadine, Theophylline,Warfarin :
Clarithromycin may increase the incidence of adverse effects of these
drugs. With Rifabutin, Rifampin : Rifabutin or rifampin may decrease the
amount of clarithromycin in the blood.With Zidovudine : Clarithromycin
may decrease the amount of zidovudine in the blood.

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Adverse
Effect & Precaution




Nausea, vomiting, dyspepsia,
diarrhoea, abdominal pain, headache, taste perversion, urticaria,
anaphylaxis, Steven Johnson syndrome, transient CNS symptoms like
anxiety, dizziness, insomnia, confusion, bad dreams.


  


Patients with severe renal
disease may have an increased risk of adverse effects.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brand
available in market

 
























ACEM

Emcure
F-C TABS 250mg 10 270.00
BICLAR

Unisearch
TAB 250mg 4 110.80
CELEX

Glaxo
F-C TABS 250mg 4 140.00
CLARIBID

Abbott
TAB 250mg 10 350.00
CLARIE

Ind-Swift
TAB 250mg 5×10 1325.00
CLARIMAC

Cadila Healthcare
TAB 250mg 4 140.00
TAB 500mg 4 275.00
CLARITHRO

Alembic
TAB 250mg 4 140.90
CRIXAN

Croslands
TABS 250mg 4 110.00
HELICLAR

Abbott
TAB 250mg 10 650.00




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Drug Information
   

     

Pharmacokinetics

Clarithromycin is absorbed from small intestine, the drug gets partially destroyed by the gastric juice so it must be administered in enteric coated form. It is mainly concentrated in the bile.

TOP
 

Indication & Dosage
 

Oral
UPPER AND LOWER RTI SUCH AS PHARUNGITIS, SINUSITIS, BRONCHITIS, PNEUMONIAS; SKIN INFECTIONS SUCH AS CELLULITIS, ERYSIPELAS: 250-500mg b.i.d for  7-14 day. Children: 7.5mg/kg 12 hourly.
ATYPICAL MYCOBACTERIAL INFECTIONS: 500 b.i.d
ERADICATION OF H.PYLORI INFECTION: 1.0-1.5G daily in divided doses as part of multidrug regimen.

TOP
 

Action
 
Spectrum of activity similar to that of erythromycin and includes most Gram-psitive bacteria, Chlamydiae, some Gram-negative and Mycoplasma. The 14-hydroxymetabolite is also active and may act synergistically. SOme atypical mycobacteria may also be susceptible. Pseudomonas and enterbacteriaceae are not susceptible to clarithromycin.

TOP
 

Interactions
 

With Carbamazepine,Digoxin, Terfenadine, Theophylline,Warfarin : Clarithromycin may increase the incidence of adverse effects of these drugs. With Rifabutin, Rifampin : Rifabutin or rifampin may decrease the amount of clarithromycin in the blood.With Zidovudine : Clarithromycin may decrease the amount of zidovudine in the blood.

TOP
 

Adverse Effect & Precaution

Nausea, vomiting, dyspepsia, diarrhoea, abdominal pain, headache, taste perversion, urticaria, anaphylaxis, Steven Johnson syndrome, transient CNS symptoms like anxiety, dizziness, insomnia, confusion, bad dreams.
  

Patients with severe renal disease may have an increased risk of adverse effects.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.

TOP
 

ACEM

Emcure

F-C TABS

250mg

10

270.00

BICLAR

Unisearch

TAB

250mg

4

110.80

CELEX

Glaxo

F-C TABS

250mg

4

140.00

CLARIBID

Abbott

TAB

250mg

10

350.00

CLARIE

Ind-Swift

TAB

250mg

5×10

1325.00

CLARIMAC

Cadila Healthcare

TAB

250mg

4

140.00

TAB

500mg

4

275.00

CLARITHRO

Alembic

TAB

250mg

4

140.90

CRIXAN

Croslands

TABS

250mg

4

110.00

HELICLAR

Abbott

TAB

250mg

10

650.00

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By |2022-07-20T16:44:44+00:00July 20, 2022|Uncategorized|Comments Off on Clarithromycin

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