Drug Information

 



     











Pharmacokinetics

 


After oral administration it is slowly absorbed, stored in RES and fatty
tissues. It has long elimination half life.

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Indication
& Dosage


 



Oral

MULTIBACILLARY LEPROSY: 50mg daily (or 100mg on alternate days)
self-administered, & 300mg once-monthly, supervised. Dapsone
(50-100mg daily) &  rifampicin (450-600mg monthly) also form
part of the regimen. Duration of regimen: Atleast 2 yrs, may be
continued until smear negativity.

TYPE-2 LEPROMATOUS REACTIONS: Doses upto 300mg daily for a max. of 3
mths.

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Action

 


It is an antileprotic
which is one of the main drugs used in regimens for the treatment of
multibacillary leprosy. It has anti-inflammatory properties & has
been given in type-2 lepral reactions & in a variety of skin
disorders.

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Interactions

  

Rifampicin: Decreases the rate of absorption of rifampicin.

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Adverse
Effect & Precaution





It causes discoluration of skin ranging from red brown to black. the
skin  lesion persist for month after drug is stopped. dy skin,
itching, acneform, eruption and phototoxicity, Nausea, abdominal pain,
anorexia & diarrhoea.



Precaution: Hepatic, renal dysfuction.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: Use with caution

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Brand
available in market











CLOFOZINE

Astra-IDL
CAPS 50mg 100 113.04
CAPS 100mg 100 204.29
HANSEPRAN

SPPL
CAPS 50mg 10 11.00
CAPS 100mg 10 23.00





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 Drug Information
 

     

Pharmacokinetics
 

After oral administration it is slowly absorbed, stored in RES and fatty tissues. It has long elimination half life.

TOP
 

Indication & Dosage
 

Oral
MULTIBACILLARY LEPROSY: 50mg daily (or 100mg on alternate days) self-administered, & 300mg once-monthly, supervised. Dapsone (50-100mg daily) &  rifampicin (450-600mg monthly) also form part of the regimen. Duration of regimen: Atleast 2 yrs, may be continued until smear negativity.
TYPE-2 LEPROMATOUS REACTIONS: Doses upto 300mg daily for a max. of 3 mths.

TOP
 

Action
 

It is an antileprotic which is one of the main drugs used in regimens for the treatment of multibacillary leprosy. It has anti-inflammatory properties & has been given in type-2 lepral reactions & in a variety of skin disorders.

TOP
 

Interactions
  
Rifampicin: Decreases the rate of absorption of rifampicin.

TOP
 

Adverse Effect & Precaution

It causes discoluration of skin ranging from red brown to black. the skin  lesion persist for month after drug is stopped. dy skin, itching, acneform, eruption and phototoxicity, Nausea, abdominal pain, anorexia & diarrhoea.

Precaution: Hepatic, renal dysfuction.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: Use with caution

TOP
 

CLOFOZINE

Astra-IDL

CAPS

50mg

100

113.04

CAPS

100mg

100

204.29

HANSEPRAN

SPPL

CAPS

50mg

10

11.00

CAPS

100mg

10

23.00

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By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on Clofazmine

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