Drug Information

  



     















Pharmacokinetics

It is absorbed
from the proximal small intestine. It is extensively distributed in the
body.It is 85 % bound to plasma proteins.Plasma half life averages 24
hours.It is metabolised in the liver. Clearance is reduced in liver
damage.It is excreted in urine.

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Indication
& Dosage


 




Oral

MYOCLONIC SEIZURES, TONIC CLONIC SEIZURES, ATONIC SEIZURES, TEMPORAL
LOBE EPILEPSYM INFANTILE SPAMS, ABSENCE SEIZURES:
Adults: Start with
1-1.5mg/day in divided doses. Increase by 0.5mg/day every 3-5 days upto
max of 20mg/day. Maintenance dose: 4-8mg daily. Children:
0.01-0.02mg/kg/day in 3-4 divided doses. Increase by 0.25-0.5mg/day
until max of 0.2mg/kg/day. Young children- 1.5-3mg/day. School going
children 3-6mg/day.

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Action

 

Clonazepam, a
benzodiazepine, is an effective anticonvulsant. It raises the threshold
for propogationof seizure activity and prevents generalization of focal
or local activity. Clinically clonazepam improves focal epilepsy and
generalised seizures.

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Interactions

 

Adverse effects of drugs like hydantoins and phenobarbitones may be
exacerbrated by clonazepam. Clonazepam potentiates the effects of
alcohol.

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Adverse
Effect & Precaution




Impaired alertness, amnesia,
drowsiness, lethary, respiratory depression, salivary and bronchial
hypersecretion in infants, somnolence behavioural problems, muscle
weakness, vertigo, ataxia, dizziness, fatigue, tolerance, anorexia,
nausea, vomiting, dyspepsia, anaemia, leucopenia. Dry mouth, blured
vision, sweating, decreased or increased appetite.

 


Allergies may occur with
Clonazepam .Special precautions to be taken in elderly, chronic
pulmonary insufficiency, neonates, porphyria and in patients with
hepatic and renal damage.

Pregnancy: Safety not established.

Breast Feeding: Contraindicated.

Man: May be given in reduced dose.

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Brand
available in market














CLONOTRIL

Torrent
TAB 0.5mg 10 8.90
TAB 2mg 10 29.50
LONAZEP

Synergy
TAB 0.5mg 10 9.00
TAB 2mg 10 29.70
RIVOTRIL

Piramal Healthcare
TAB 0.5mg 10 16.16
TAB 2mg 10 42.78



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Drug Information
  

     

Pharmacokinetics

It is absorbed from the proximal small intestine. It is extensively distributed in the body.It is 85 % bound to plasma proteins.Plasma half life averages 24 hours.It is metabolised in the liver. Clearance is reduced in liver damage.It is excreted in urine.

TOP
   

Indication & Dosage
 

Oral
MYOCLONIC SEIZURES, TONIC CLONIC SEIZURES, ATONIC SEIZURES, TEMPORAL LOBE EPILEPSYM INFANTILE SPAMS, ABSENCE SEIZURES:
Adults: Start with 1-1.5mg/day in divided doses. Increase by 0.5mg/day every 3-5 days upto max of 20mg/day. Maintenance dose: 4-8mg daily. Children: 0.01-0.02mg/kg/day in 3-4 divided doses. Increase by 0.25-0.5mg/day until max of 0.2mg/kg/day. Young children- 1.5-3mg/day. School going children 3-6mg/day.

TOP
   

Action
 
Clonazepam, a benzodiazepine, is an effective anticonvulsant. It raises the threshold for propogationof seizure activity and prevents generalization of focal or local activity. Clinically clonazepam improves focal epilepsy and generalised seizures.

TOP
   

Interactions
 
Adverse effects of drugs like hydantoins and phenobarbitones may be exacerbrated by clonazepam. Clonazepam potentiates the effects of alcohol.

TOP
   

Adverse Effect & Precaution

Impaired alertness, amnesia, drowsiness, lethary, respiratory depression, salivary and bronchial hypersecretion in infants, somnolence behavioural problems, muscle weakness, vertigo, ataxia, dizziness, fatigue, tolerance, anorexia, nausea, vomiting, dyspepsia, anaemia, leucopenia. Dry mouth, blured vision, sweating, decreased or increased appetite.
 

Allergies may occur with Clonazepam .Special precautions to be taken in elderly, chronic pulmonary insufficiency, neonates, porphyria and in patients with hepatic and renal damage.
Pregnancy: Safety not established.
Breast Feeding: Contraindicated.
Man: May be given in reduced dose.

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CLONOTRIL

Torrent

TAB

0.5mg

10

8.90

TAB

2mg

10

29.50

LONAZEP

Synergy

TAB

0.5mg

10

9.00

TAB

2mg

10

29.70

RIVOTRIL

Piramal Healthcare

TAB

0.5mg

10

16.16

TAB

2mg

10

42.78

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By |2022-07-20T16:44:44+00:00July 20, 2022|Uncategorized|Comments Off on Clonazepam

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