Drug Information

    



     











Pharmacokinetics

 


Given orally absorption of
Cloxacillin is interfered with by food. It reaches high plasma levels in
an hour. It is highly concentrated in the kidneys.

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Indication
& Dosage


 




SKIN AND SOFT TISSUE INFECTIONS, BURNS MASTITIS,
OSTEOMYELITIS, TONSILLAR ASCESS, PNENONIA, ENDOCARDITIS (STAPH) AND
PROPHYLAXIS AGAINST IT, SURGICAL INFECTIONS:
500mg 6 hrly may be doubled
in severe infections. Children-2-10 yrs: Half adult dose. Under 2 yrs:
quarter adult dose. A daily dose of 18g has been used for acute
haematogenous osteitis and Staph infections of CNS.




IM/IV

SEVERE INFECTIONS:
iM: 250-500mg q.i.d IV: 1-4g q.i.d. Children:
25-100mg/kg divided doses.


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Action

 


Cloxacillin is resistant
to degradation by penicillinase. It is particularly useful against
penicillinase-producing staphytococci. Highly active against Staph.
aureus, Strep. pyogenes, Strep. viridans and Strep.pneumoniae.

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Interactions

There is loss
of potency of cloxacilin when used with Erythromycin, gentamycin and
Kanamycin. Cloxacillin should not be added to blood products and IV
lipids.






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Adverse
Effect & Precaution




Hypersenstivity reactions
which may range from skin rash, drug fever, urticaria to severe
anaphylactic reaction.

In Allergy,:
Patients with a history of general allergies may be more likely to
develop a severe reaction to Cloxacillin. Renal disease: Patients with
renal disease may have an increased chance of adverse effects. Stomach
or intestinal disease, (especially colitis, including colitis caused by
antibiotics) : Patients with a history of stomach or intestinal disease
may be more likely to develop colitis while taking Cloxacillin.

Pregnancy: May be used.

Breast Feeding: May be used.

Man: May be used.

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Brand
available in market


 

























BIOCLOX

Biochem
CAPS 250mg 10 29.69
CAPS 500mg 10 52.85
INJ 250mg VIAL 9.97
INJ 500mg VIAL 14.60
CLOCILIN

PCI
CAPS 250mg 10 20.38
CAPS 500mg 10 40.00
INJ 250mg VIAL 6.83
INJ 500mg VIAL 9.83
CLOPEN

Lark
CAPS 250mg 10 22.36
CAPS 500mg 10 44.21
DRY SYRUP 125mg/5ml 40ML 12.00
KLOX

Lyka
INJ 250mg VIAL 8.26
INJ 500mg VIAL 11.43
CAPS 250mg 15 29.28
CAPS 500mg 15 53.56
SYRUP 125mg/5ml 40ml 12.41


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Drug Information
    

     

Pharmacokinetics
 

Given orally absorption of Cloxacillin is interfered with by food. It reaches high plasma levels in an hour. It is highly concentrated in the kidneys.

TOP
  

Indication & Dosage
 

SKIN AND SOFT TISSUE INFECTIONS, BURNS MASTITIS, OSTEOMYELITIS, TONSILLAR ASCESS, PNENONIA, ENDOCARDITIS (STAPH) AND PROPHYLAXIS AGAINST IT, SURGICAL INFECTIONS: 500mg 6 hrly may be doubled in severe infections. Children-2-10 yrs: Half adult dose. Under 2 yrs: quarter adult dose. A daily dose of 18g has been used for acute haematogenous osteitis and Staph infections of CNS.

IM/IV
SEVERE INFECTIONS:
iM: 250-500mg q.i.d IV: 1-4g q.i.d. Children: 25-100mg/kg divided doses.

TOP
  

Action
 

Cloxacillin is resistant to degradation by penicillinase. It is particularly useful against penicillinase-producing staphytococci. Highly active against Staph. aureus, Strep. pyogenes, Strep. viridans and Strep.pneumoniae.

TOP
  

Interactions

There is loss of potency of cloxacilin when used with Erythromycin, gentamycin and Kanamycin. Cloxacillin should not be added to blood products and IV lipids.



TOP
  

Adverse Effect & Precaution

Hypersenstivity reactions which may range from skin rash, drug fever, urticaria to severe anaphylactic reaction.

In Allergy,: Patients with a history of general allergies may be more likely to develop a severe reaction to Cloxacillin. Renal disease: Patients with renal disease may have an increased chance of adverse effects. Stomach or intestinal disease, (especially colitis, including colitis caused by antibiotics) : Patients with a history of stomach or intestinal disease may be more likely to develop colitis while taking Cloxacillin.
Pregnancy: May be used.
Breast Feeding: May be used.
Man: May be used.

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BIOCLOX

Biochem

CAPS

250mg

10

29.69

CAPS

500mg

10

52.85

INJ

250mg

VIAL

9.97

INJ

500mg

VIAL

14.60

CLOCILIN

PCI

CAPS

250mg

10

20.38

CAPS

500mg

10

40.00

INJ

250mg

VIAL

6.83

INJ

500mg

VIAL

9.83

CLOPEN

Lark

CAPS

250mg

10

22.36

CAPS

500mg

10

44.21

DRY SYRUP

125mg/5ml

40ML

12.00

KLOX

Lyka

INJ

250mg

VIAL

8.26

INJ

500mg

VIAL

11.43

CAPS

250mg

15

29.28

CAPS

500mg

15

53.56

SYRUP

125mg/5ml

40ml

12.41

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By |2022-07-20T16:44:45+00:00July 20, 2022|Uncategorized|Comments Off on Cloxacillin

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