Drug Information

     


  



D-Penicillamine 



         















Pharmacokinetics  

D-penicillamine
is a degradation product of penicillin. Only the d-isomer is used because
l-isomer causes optic neuritis. It is slowly but adequately absorbed after
oral administration. The drug gets metabolised in the body and is excreted
in the urine and faeces.

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Indication and Dosage


 

Oral : 

WILSON’S DISEASE: 

Adults : 1.5-2g/day in divided doses 1 hr before food or 2hr after food:
max 2g daily for 1yr,

Maintenance : 0.75-1g daily. Children: Ip tp 20mg/kg/day in divided doses
(min: 500mg daily).



                                                                         
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Action

 

D-penicillamine is a chelating agent recommended for the
removal of excess copper in patients with wilson’s diesease. It is also
useful to reduce excess cystine excration in cystinuria, and to trat
active rheumatoid arthritis unresponsive to conventional therapy. In
rheumatoid arthritis it is reportedly effective by reducing lgM levels
& T-cell actively.

                                                                          

                                                                         

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Interaction

When using D-penicillamine
drugs like gold, Chloroquine, and immunosupressive agents should be
avoided. Iron, Antacids and zinc interferes with absorption of D-penicillamine.




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Special Precautions :



On i.v. injection : Flushing, urticaria hyportension, shock, tachypnoea,
hypoxaemia, tachycardia, cardiac arrhythmias, convulsions.

On s.c. or i.m.Local pain pruritus, erythema, swelling, GIT disturbances,
dysuria, fever, allergic dkin rashes. Leg cramps on long term therapy
Reversible ocular and auditory distrbances. Reduction of growth in very
young children, thrombocytopenia.

 

When adminstered over prolonged periods,
visual acuty tests,slit lamp examinations, funduscopy and audiometry are
recomended periodically. Impaired renal function, children below 3 years
Increased susceptibility to infection, particularly for  Yersinia
species. Concomitant use of ascorbic acid. Servere fungal infections have
been reported.

Pregnancy : May be used with caution only if potential benefit outweights
risks to the foetus.

Brest Feeding : Use with caution.

Men : May  be used.

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Brands available in
Market


 














Alfacal
CAPS 0.25mcg Macleods
Alfacip


CAPS 0.25mcg Cipla
CAPS 1mcg Cipla
Alpha D3


CAPS 0.25mcg Biddle Sawyer
CAPS 1mcg Biddle Sawyer
Alphadol


CAPS 0.25mcg Panacea
CAPS 1mcg Panacea
CAPS 1mcg Panacea
One Alpha


CAPS 0.25mcg Croslands
CAPS 1mcg Croslands




  
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 Drug Information
     

  
D-Penicillamine 
         

Pharmacokinetics  

D-penicillamine is a degradation product of penicillin. Only the d-isomer is used because l-isomer causes optic neuritis. It is slowly but adequately absorbed after oral administration. The drug gets metabolised in the body and is excreted in the urine and faeces.

 TOP

Indication and Dosage
 
Oral : 
WILSON’S DISEASE: 
Adults : 1.5-2g/day in divided doses 1 hr before food or 2hr after food: max 2g daily for 1yr,
Maintenance : 0.75-1g daily. Children: Ip tp 20mg/kg/day in divided doses (min: 500mg daily).

                                                                         
TOP
   

Action
 
D-penicillamine is a chelating agent recommended for the removal of excess copper in patients with wilson’s diesease. It is also useful to reduce excess cystine excration in cystinuria, and to trat active rheumatoid arthritis unresponsive to conventional therapy. In rheumatoid arthritis it is reportedly effective by reducing lgM levels & T-cell actively.
                                                                          
                                                                         
TOP

 

Interaction

When using D-penicillamine drugs like gold, Chloroquine, and immunosupressive agents should be avoided. Iron, Antacids and zinc interferes with absorption of D-penicillamine.


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Special Precautions :

On i.v. injection : Flushing, urticaria hyportension, shock, tachypnoea, hypoxaemia, tachycardia, cardiac arrhythmias, convulsions.
On s.c. or i.m.Local pain pruritus, erythema, swelling, GIT disturbances, dysuria, fever, allergic dkin rashes. Leg cramps on long term therapy Reversible ocular and auditory distrbances. Reduction of growth in very young children, thrombocytopenia.

 
When adminstered over prolonged periods, visual acuty tests,slit lamp examinations, funduscopy and audiometry are recomended periodically. Impaired renal function, children below 3 years Increased susceptibility to infection, particularly for  Yersinia species. Concomitant use of ascorbic acid. Servere fungal infections have been reported.
Pregnancy : May be used with caution only if potential benefit outweights risks to the foetus.
Brest Feeding : Use with caution.
Men : May  be used.

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Brands available in Market

 

Alfacal

CAPS

0.25mcg

Macleods

Alfacip

CAPS

0.25mcg

Cipla

CAPS

1mcg

Cipla

Alpha D3

CAPS

0.25mcg

Biddle Sawyer

CAPS

1mcg

Biddle Sawyer

Alphadol

CAPS

0.25mcg

Panacea

CAPS

1mcg

Panacea

CAPS

1mcg

Panacea

One Alpha

CAPS

0.25mcg

Croslands

CAPS

1mcg

Croslands

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By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on D-Penicillamine

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