Drug
Information

       



Danazol 

  











Pharmacokinetics



Danazol is absorbed from the
gastrointestinal tract and metabolised in the liver; absorption is said
to be markedly increased if it is taken with food. A half-life of about
4.5 hours has been reported. 2-Hydroxymethylethisterone is said to be
the major metabolite.

Top

  

Indication &
Dosage




Oral

Endometriosis, Infertility due to endometriosis, Fibrocystic breast
disease, Precocious puberty, Gynaecomastia, menorrhagia: 200-800 mg
daily in 2 divided doses for upto 6 months. Pregnancy should be
eliminated and danazol therapy should begin during menstruation.

Top

   

Action



Danazol supresses
pituitary-ovarian axis. It reduces the release of both FSH and LH.
Danazol has a weak androgenic activity. Endometrial tissue becomes
atrophic. Endometrial lesions regress. In fibrocystic breast disease
danazol causes partial to complete disappearance of nodularity with
complete relief of pain and tenderness. In herediatary angioedema
danazol prevents recurrent attacks of oedema of face, airways, abdominal
viscera and extremitees. In infertility caused by endometriosis(after a
course of danazol) ovulation returns 30-90 days after stopping the drug.

Top

   

Interaction

 

Insulin : Increase in insulin
requirement in diabetics due to insulin resistance.

warfarin : Potentiation of anticoagulant effect. 

Oral contraceptives : Interfere with danazol action.

Anti-epileptics : May require adjustment in their doses.

Lab Tests : Glucose Tolerance

Tests : Decreased glucose tolerance.

Liver Function Tests : Elevated values reported.

Top

   

Precaution



Skin rash, nausea,
flushing, muscle spasm, weight gain, headache, acne, hirsutism, loss of
libido, amenorrhoea, cholestatic jaundice.


 


Special Precautions : Diabetes,
cardiac, renal, or hepatic dysfunction,hypertension, migraine, epilepsy.
Liver function test to be done. Prolonged used

Pregnancy : Contraindicated 

Brest Feeding : Contraindicated 

 

Brands available in
Market




 























Danogen

Cipla
Caps 50mg 10 79.00
Caps 100mg 10 156.00
Caps 200mg 10 253.30
Endometryl

Ar-Ex.Lab
Caps 50mg 30 39.00
Caps 100mg 30 77.00
Caps 200mg 30 132.00
Gonablok

Win-Medicare
Caps 50mg 30 299.25
Caps 100mg 30 558.60
Caps 200mg 30 990.00
Gynazol

Sun Pharma
Caps 50mg 3×10 215.00
Caps 100mg 3×10 425.00
Caps 200mg 3×10 715.00
Zendol

Serum International
Caps 50mg 10 72.00
Caps 100mg 10 135.00
Caps 200mg 10 227.00








Top 

          







 

 

Drug Information
       

Danazol 
  

Pharmacokinetics

Danazol is absorbed from the gastrointestinal tract and metabolised in the liver; absorption is said to be markedly increased if it is taken with food. A half-life of about 4.5 hours has been reported. 2-Hydroxymethylethisterone is said to be the major metabolite.

Top
  

Indication & Dosage

Oral
Endometriosis, Infertility due to endometriosis, Fibrocystic breast disease, Precocious puberty, Gynaecomastia, menorrhagia: 200-800 mg daily in 2 divided doses for upto 6 months. Pregnancy should be eliminated and danazol therapy should begin during menstruation.

Top
   

Action

Danazol supresses pituitary-ovarian axis. It reduces the release of both FSH and LH. Danazol has a weak androgenic activity. Endometrial tissue becomes atrophic. Endometrial lesions regress. In fibrocystic breast disease danazol causes partial to complete disappearance of nodularity with complete relief of pain and tenderness. In herediatary angioedema danazol prevents recurrent attacks of oedema of face, airways, abdominal viscera and extremitees. In infertility caused by endometriosis(after a course of danazol) ovulation returns 30-90 days after stopping the drug.

Top
   

Interaction
 
Insulin : Increase in insulin requirement in diabetics due to insulin resistance.
warfarin : Potentiation of anticoagulant effect. 
Oral contraceptives : Interfere with danazol action.
Anti-epileptics : May require adjustment in their doses.
Lab Tests : Glucose Tolerance
Tests : Decreased glucose tolerance.
Liver Function Tests : Elevated values reported.

Top
   

Precaution

Skin rash, nausea, flushing, muscle spasm, weight gain, headache, acne, hirsutism, loss of libido, amenorrhoea, cholestatic jaundice.
 

Special Precautions : Diabetes, cardiac, renal, or hepatic dysfunction,hypertension, migraine, epilepsy. Liver function test to be done. Prolonged used
Pregnancy : Contraindicated 
Brest Feeding : Contraindicated 

 

 

Danogen

Cipla

Caps

50mg

10

79.00

Caps

100mg

10

156.00

Caps

200mg

10

253.30

Endometryl

Ar-Ex.Lab

Caps

50mg

30

39.00

Caps

100mg

30

77.00

Caps

200mg

30

132.00

Gonablok

Win-Medicare

Caps

50mg

30

299.25

Caps

100mg

30

558.60

Caps

200mg

30

990.00

Gynazol

Sun Pharma

Caps

50mg

3×10

215.00

Caps

100mg

3×10

425.00

Caps

200mg

3×10

715.00

Zendol

Serum International

Caps

50mg

10

72.00

Caps

100mg

10

135.00

Caps

200mg

10

227.00


Top 
          

 

By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on Danazol

About the Author: