Pharmacokinetics
 


Desferrioxamine mesylate is poorly
absorbed from the gastrointestinal tract. Following parenteral
administration, desferrioxamine forms chelates with metal ions and is
also metabolised, primarily in the plasma. The iron-desferrioxamine
chelate is excreted in the urine and bile. Desferrioxamine is absorbed
during peritoneal dialysis if added to the dialysis fluid.

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Indication &
Dosage

 

Acute Iron Poisoning : IM inj. for patients not in shock: 1g
initially followed by 500mg every 4hrs for two doses. Subsequent doses
500mg 4-12hrly as reqd. upto a max. of 69 in 24hours.
IV infusion for patients with cardiovascular collapse : 15mg/kg/hr max
80mg/kg in 24hrs.
Chronic Iron Overload(Ex:Transfusional Hemosiderosis Esp. In Thalassemia
Patients): Daily dose of 0.5-1g IM. Additionally 2g IV infusion given
separately with each unit of blood transfused. Diagnostic test for Iron
Storage Disease: Inject500mg IM & measure urinary iron in the next
6hrs. Excretion of 1mg iron is suggestive of iron storage disease &
more than 1.5mg is pathological.

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Action

It is a chelating agent which has a high affinity for ferric iron.
When injected, it is forums a stable water-soluble iron-complex
(ferrioxamine) which is readily excreated in the urine & in bile. It
can also chelate aluminium & thus useful in aluminium overload.
Nonetheless, Desferrioxamine is primarily a chelator used in acute iron
poisoning & chronic iron overload.

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Interaction
 

Desferrioxamine is usually
administered parenterally and thus drug interactions due to chelation
with oral metal ions are not a problem.

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Adverse
Effect & Precaution

On i.v. injection : Flushing,
urticaria, hypotension, shock, tachypnoea, hypoxaemia, tachycardia, cardiac arrhythmias, convulsions.
On s.c. or i.m. : Local pain, pruritus, erythema, swelling, GIT
disturbances, dysuria, fever, allergic skin rashes. Leg cramps on long
term therapy. Reversible ocular and auditory disturbances. Reduction of
growth in very young children, thrombocytopenia.
 
When adminstered over prolonged periods, visual acuity tests,
slitlamp examinations, funduscopy and audiometry are recommended
periodically. Impaired renal function, children below 3 years. Increased
susceptibiliby to infection, particularly for Yersinia species.
Concomitant use of ascorbic acid. Severe fungal infections  have
been reported.
Pregnancy : May be used with caution only if potential benefit outweighs
risks to the foetus.
Brest Feeding : Use with caution.
Men : May be used.

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Brands available in
Market

 
 

Desferal Novartis
Inj. 500mg/vial 5 692

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Pharmacokinetics

Desferrioxamine mesylate is poorly absorbed from the gastrointestinal tract. Following parenteral administration, desferrioxamine forms chelates with metal ions and is also metabolised, primarily in the plasma. The iron-desferrioxamine chelate is excreted in the urine and bile. Desferrioxamine is absorbed during peritoneal dialysis if added to the dialysis fluid.

Top

Indication & Dosage

Acute Iron Poisoning : IM inj. for patients not in shock: 1g initially followed by 500mg every 4hrs for two doses. Subsequent doses 500mg 4-12hrly as reqd. upto a max. of 69 in 24hours.
IV infusion for patients with cardiovascular collapse : 15mg/kg/hr max 80mg/kg in 24hrs.
Chronic Iron Overload(Ex:Transfusional Hemosiderosis Esp. In Thalassemia Patients): Daily dose of 0.5-1g IM. Additionally 2g IV infusion given separately with each unit of blood transfused. Diagnostic test for Iron Storage Disease: Inject500mg IM & measure urinary iron in the next 6hrs. Excretion of 1mg iron is suggestive of iron storage disease & more than 1.5mg is pathological.

Top

Action

It is a chelating agent which has a high affinity for ferric iron. When injected, it is forums a stable water-soluble iron-complex (ferrioxamine) which is readily excreated in the urine & in bile. It can also chelate aluminium & thus useful in aluminium overload. Nonetheless, Desferrioxamine is primarily a chelator used in acute iron poisoning & chronic iron overload.

Top

Interaction

Desferrioxamine is usually administered parenterally and thus drug interactions due to chelation with oral metal ions are not a problem.

Top

Adverse Effect & Precaution

On i.v. injection : Flushing, urticaria, hypotension, shock, tachypnoea, hypoxaemia, tachycardia, cardiac arrhythmias, convulsions.
On s.c. or i.m. : Local pain, pruritus, erythema, swelling, GIT disturbances, dysuria, fever, allergic skin rashes. Leg cramps on long term therapy. Reversible ocular and auditory disturbances. Reduction of growth in very young children, thrombocytopenia.

When adminstered over prolonged periods, visual acuity tests, slitlamp examinations, funduscopy and audiometry are recommended periodically. Impaired renal function, children below 3 years. Increased susceptibiliby to infection, particularly for Yersinia species. Concomitant use of ascorbic acid. Severe fungal infections have been reported.
Pregnancy : May be used with caution only if potential benefit outweighs risks to the foetus.
Brest Feeding : Use with caution.
Men : May be used.

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Desferal

Novartis

Inj.

500mg/vial

5

692

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