Drug
Information


         






Desmopressin

   












Pharmacokinetics

 



It is administered intranasal.

Top 

  

Indication &
Dosage


 


Nasal Spray/Intranasal Solution Cranial Diabetes Insipidus: 

Adults:20-40mcg/day in single or 2-3 div. doses. childern : 10-20 mcg
daily in single or div. doses. Primary nocturnal enuresis:Dosage ranges
between 10-40mcggiven nightly.

Renal Functional Testing: Empty bladder at a time of testing.
Adults:40mcg. Children:10-20mcg(restrict fluid intake).

SC/IV

Cranial Diabetes Insipidus:2-4mcg/day SC/Iv in 2div. doses.Morning and
evening doses are set at different leaves to suit diurnal rhythm of
water turnover.

Hemophilia a & Von Willebrand’s Disease (IV Infusion):IV infusion at
a dose of 0.3mcg/kg diluted in sterile physiological saline over
15-30mins. In adults & childern over 10kg, 10ml of diluent is used.
When used preoperatively, it is given 30mins prior to pricedure.

Top 

 

Action

 


Antidiuresis is the principal action which is exerted via the
V2 receptor liked adenyl cyclase system in the collecting tubule. This
action makes the peptide ideal for the treatment of central diabetes
insipidus & nocturnal enuresis. At high doses, this peptide
increases plasminogen activator from endothelial cells; successfully
used in certain bleeding disorders. 

Top 

   

Interaction




Analgesics: Effect of desmopressin
potentiated by indomethacin.

Top 

    
 

Adverse
Effect & Precaution





Fluid retenion, hyponatraemia on administration without
restricting fluid intake, stomach ache, head ache, nausea, vomiting,
epistaxis. Allergic reactions ranging from urticaria to anaphylaxis may
occur.




Special precautions : Renal impairment, cardiovascular disease and
hypertension (not indicated for nocturnal enuresis and nctura in those
over 65 years), cystic fibrosis.

Pregnancy : Contraindicated.

Brest Feeding : Contraindicated.

Men : Contraindicated.

Top 

  

Brands available in
Market







D-VOID

Sun Pharma
Nasal
Spray
5ml 1mcg/ml 980.00


Top 

    







 

             

Drug Information
         


Desmopressin
   

Pharmacokinetics
 
It is administered intranasal.

Top 
  

Indication & Dosage
 

Nasal Spray/Intranasal Solution Cranial Diabetes Insipidus: 
Adults:20-40mcg/day in single or 2-3 div. doses. childern : 10-20 mcg daily in single or div. doses. Primary nocturnal enuresis:Dosage ranges between 10-40mcggiven nightly.
Renal Functional Testing: Empty bladder at a time of testing. Adults:40mcg. Children:10-20mcg(restrict fluid intake).
SC/IV
Cranial Diabetes Insipidus:2-4mcg/day SC/Iv in 2div. doses.Morning and evening doses are set at different leaves to suit diurnal rhythm of water turnover.
Hemophilia a & Von Willebrand’s Disease (IV Infusion):IV infusion at a dose of 0.3mcg/kg diluted in sterile physiological saline over 15-30mins. In adults & childern over 10kg, 10ml of diluent is used. When used preoperatively, it is given 30mins prior to pricedure.

Top 
 

Action
 

Antidiuresis is the principal action which is exerted via the V2 receptor liked adenyl cyclase system in the collecting tubule. This action makes the peptide ideal for the treatment of central diabetes insipidus & nocturnal enuresis. At high doses, this peptide increases plasminogen activator from endothelial cells; successfully used in certain bleeding disorders. 

Top 
   

Interaction

Analgesics: Effect of desmopressin potentiated by indomethacin.

Top 
    
 

Adverse Effect & Precaution

Fluid retenion, hyponatraemia on administration without restricting fluid intake, stomach ache, head ache, nausea, vomiting, epistaxis. Allergic reactions ranging from urticaria to anaphylaxis may occur.

Special precautions : Renal impairment, cardiovascular disease and hypertension (not indicated for nocturnal enuresis and nctura in those over 65 years), cystic fibrosis.
Pregnancy : Contraindicated.
Brest Feeding : Contraindicated.
Men : Contraindicated.

Top 
  

D-VOID

Sun Pharma

Nasal Spray

5ml

1mcg/ml

980.00

Top 
    

 

By |2022-07-20T16:44:43+00:00July 20, 2022|Uncategorized|Comments Off on Desmopressin

About the Author: